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Published in: World Journal of Surgery 8/2009

01-08-2009

Extension of Nonoperative Management of Blunt Pancreatic Trauma to Include Grade III Injuries: A Safety Analysis

Authors: Giacomo Pata, Claudio Casella, Ernesto Di Betta, Luigi Grazioli, Bruno Salerni

Published in: World Journal of Surgery | Issue 8/2009

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Abstract

Background

In hemodynamically stable patients after blunt pancreatic trauma, the main pancreatic duct (MPD) disruption (American Association for the Surgery of Trauma [AAST] grade III-IV-V lesions) is usually treated surgically or by endoscopic stent placement, whereas injuries without duct involvement (grade I-II) are liable to medical treatment. To date, no evidence has been reported regarding nonoperative management (NoM) of grade III injuries. We aimed to evaluate the safety of extending medical management to include cases of distal MPD involvement (grade III).

Patients and methods

Data were collected on patients admitted after blunt pancreatic trauma between January 1999 and December 2007. Patients exhibiting hemodynamic instability or hollow organ perforations were excluded from this study, as they were surgically managed. In all remaining cases NoM was attempted. Antibiotic prophylaxis and early total enteral nutrition were routinely adopted. Grade III patients received octreotide during hospitalization and for 6 months after discharge.

Results

Eleven patients (2 with grade I injury, 3 with grade II injury, and 6 with grade III injury, all diagnosed by contrast-enhanced helical CT) were included. Nonsurgical management was carried out in all of these patients. Among grade III patients, one developed a peripancreatic abscess; another, a pancreatic fistula. Both were successfully treated nonoperatively. The average length of hospital stay was similar in grade I-II and grade III patients. After a median follow-up of 57 months no mortality or pancreatic sequelae had occurred.

Conclusions

Under the aforementioned conditions, an attempt to extend NoM to include patients with AAST-grade III lesions can be justified. However, such a strategy demands continuous patient monitoring, because should the case worsen, surgery might become necessary.
Literature
1.
go back to reference Lin BC, Chen RJ, Fang JF et al (2004) Management of blunt major pancreatic injury. J Trauma 56:774–778PubMedCrossRef Lin BC, Chen RJ, Fang JF et al (2004) Management of blunt major pancreatic injury. J Trauma 56:774–778PubMedCrossRef
2.
go back to reference Wolf A, Bernhardt J, Patrzyk M et al (2005) The value of endoscopic diagnosis and the treatment of pancreas injuries following blunt abdominal trauma. Surg Endosc 19:665–669PubMedCrossRef Wolf A, Bernhardt J, Patrzyk M et al (2005) The value of endoscopic diagnosis and the treatment of pancreas injuries following blunt abdominal trauma. Surg Endosc 19:665–669PubMedCrossRef
3.
go back to reference Tyburski JG, Dente CJ, Wilson RF et al (2001) Infectious complications following duodenal and/or pancreatic trauma. Am Surg 67:227–231PubMed Tyburski JG, Dente CJ, Wilson RF et al (2001) Infectious complications following duodenal and/or pancreatic trauma. Am Surg 67:227–231PubMed
4.
go back to reference Wong YC, Lj Wang, Lin BC et al (1997) CT grading of blunt pancreatic injuries: prediction of ductal disruption and surgical correlation. J Comput Assist Tomogr 21:246–250PubMedCrossRef Wong YC, Lj Wang, Lin BC et al (1997) CT grading of blunt pancreatic injuries: prediction of ductal disruption and surgical correlation. J Comput Assist Tomogr 21:246–250PubMedCrossRef
5.
go back to reference Ilahi O, Bochicchio GV, Scalea TM (2002) Efficacy of computed tomography in the diagnosis of pancreatic injuries in adult blunt trauma patients: a single-institutional study. Am Surg 68:704–708PubMed Ilahi O, Bochicchio GV, Scalea TM (2002) Efficacy of computed tomography in the diagnosis of pancreatic injuries in adult blunt trauma patients: a single-institutional study. Am Surg 68:704–708PubMed
6.
go back to reference Akhrass R, Yaffe MB, Brandt CP et al (1997) Pancreatic trauma: a ten-year multi-institutional experience. Am Surg 63:598–604PubMed Akhrass R, Yaffe MB, Brandt CP et al (1997) Pancreatic trauma: a ten-year multi-institutional experience. Am Surg 63:598–604PubMed
7.
go back to reference Madida TE, Mokoena TR (1995) Favorable prognosis after surgical drainage of gunshot, stab or blunt trauma of the pancreas. Br J Surg 82:1236–1239CrossRef Madida TE, Mokoena TR (1995) Favorable prognosis after surgical drainage of gunshot, stab or blunt trauma of the pancreas. Br J Surg 82:1236–1239CrossRef
8.
go back to reference Bradley EL 3rd, Young PR Jr, Chang MC et al (1998) Diagnosis and initial management of blunt pancreatic trauma: guidelines from a multi-institutional review. Ann Surg 227:861–869PubMedCrossRef Bradley EL 3rd, Young PR Jr, Chang MC et al (1998) Diagnosis and initial management of blunt pancreatic trauma: guidelines from a multi-institutional review. Ann Surg 227:861–869PubMedCrossRef
9.
go back to reference Ryan S, Sandler A, Trenhaile S et al (1994) Pancreatic enzyme elevations after blunt trauma. Surgery 116:622–627PubMed Ryan S, Sandler A, Trenhaile S et al (1994) Pancreatic enzyme elevations after blunt trauma. Surgery 116:622–627PubMed
10.
go back to reference Lane MJ, Mindelnuz RE, Jeffrey RB (1996) Diagnosis of pancreatic injury after blunt abdominal trauma. Semin Ultrasound CT MR 17:177–182PubMedCrossRef Lane MJ, Mindelnuz RE, Jeffrey RB (1996) Diagnosis of pancreatic injury after blunt abdominal trauma. Semin Ultrasound CT MR 17:177–182PubMedCrossRef
11.
go back to reference Shilyansky J, Sena LM, Kreller M et al (1998) Nonoperative management of pancreatic injuries in children. J Pediatr Surg 33:343–349PubMedCrossRef Shilyansky J, Sena LM, Kreller M et al (1998) Nonoperative management of pancreatic injuries in children. J Pediatr Surg 33:343–349PubMedCrossRef
12.
go back to reference Kouchi K, Tanabe M, Yoshida H et al (1999) Nonoperative management of blunt pancreatic injury in childhood. J Pediatr Surg 34:1736–1739PubMedCrossRef Kouchi K, Tanabe M, Yoshida H et al (1999) Nonoperative management of blunt pancreatic injury in childhood. J Pediatr Surg 34:1736–1739PubMedCrossRef
13.
go back to reference Wales PW, Shuckett B, Kim PCW (2001) Long-term outcome after nonoperative management of complete traumatic pancreatic transection in children. J Pediatr Surg 36:823–827PubMedCrossRef Wales PW, Shuckett B, Kim PCW (2001) Long-term outcome after nonoperative management of complete traumatic pancreatic transection in children. J Pediatr Surg 36:823–827PubMedCrossRef
14.
go back to reference Wong YC, Wang LJ, Fang JF et al (2008) Multidetector-row computed tomography (CT) of blunt pancreatic injuries: can contrast-enhanced multiphasic CT detect pancreatic duct injuries? J Trauma 64:666–672PubMedCrossRef Wong YC, Wang LJ, Fang JF et al (2008) Multidetector-row computed tomography (CT) of blunt pancreatic injuries: can contrast-enhanced multiphasic CT detect pancreatic duct injuries? J Trauma 64:666–672PubMedCrossRef
15.
go back to reference Fulcher AS, Turner MA, Yelon JA et al (2000) Magnetic resonance cholangiopancreatography (MRCP) in the assessment of pancreatic duct trauma and its sequelae: preliminary findings. J Trauma 48:1001–1007PubMedCrossRef Fulcher AS, Turner MA, Yelon JA et al (2000) Magnetic resonance cholangiopancreatography (MRCP) in the assessment of pancreatic duct trauma and its sequelae: preliminary findings. J Trauma 48:1001–1007PubMedCrossRef
16.
go back to reference Bofferd KD, Brooks AJ (2000) Pancreatic trauma—injuries to the pancreas and pancreatic duct. Eur J Surg 166:4–12 Bofferd KD, Brooks AJ (2000) Pancreatic trauma—injuries to the pancreas and pancreatic duct. Eur J Surg 166:4–12
17.
go back to reference Teh SH, Sheppard BC, Mullins RJ et al (2007) Diagnosis and management of blunt pancreatic ductal injury in the era of high-resolution computed axial tomography. Am J Surg 193:641–643PubMedCrossRef Teh SH, Sheppard BC, Mullins RJ et al (2007) Diagnosis and management of blunt pancreatic ductal injury in the era of high-resolution computed axial tomography. Am J Surg 193:641–643PubMedCrossRef
19.
go back to reference Collen MJ, Hanan MR, Maher JA et al (1980) Modification of endoscopic retrograde cholangiopancreatography (ERCP) septic complications by the addition of an antibiotic to the contrast media: randomized controlled investigation. Am J Gastroenterol 74:493–496PubMed Collen MJ, Hanan MR, Maher JA et al (1980) Modification of endoscopic retrograde cholangiopancreatography (ERCP) septic complications by the addition of an antibiotic to the contrast media: randomized controlled investigation. Am J Gastroenterol 74:493–496PubMed
20.
go back to reference Thomopoulos KC, Pagoni NA, Vagenas KA et al (2006) Twenty-four hour prophylaxis with increased dosage of octreotide reduces the incidence of post-ERCP pancreatitis. Gastrointest Endosc 64:726–731PubMedCrossRef Thomopoulos KC, Pagoni NA, Vagenas KA et al (2006) Twenty-four hour prophylaxis with increased dosage of octreotide reduces the incidence of post-ERCP pancreatitis. Gastrointest Endosc 64:726–731PubMedCrossRef
21.
go back to reference Andriulli A, Leandro G, Niro G et al (2000) Pharmacologic treatment can prevent pancreatic injury after ERCP: a meta-analysis. Gastrointest Endosc 51:100–103CrossRef Andriulli A, Leandro G, Niro G et al (2000) Pharmacologic treatment can prevent pancreatic injury after ERCP: a meta-analysis. Gastrointest Endosc 51:100–103CrossRef
22.
go back to reference Foster E, Leung J (2007) Pharmacotherapy for the prevention of post-ERCP pancreatitis. Am J Gastroenterol 102:52–55PubMedCrossRef Foster E, Leung J (2007) Pharmacotherapy for the prevention of post-ERCP pancreatitis. Am J Gastroenterol 102:52–55PubMedCrossRef
23.
go back to reference Hardt PD, Kress O, Fadgyas T et al (2000) Octreotide in the prevention of pancreatic damage induced by endoscopic sphincterotomy. Eur J Med Res 5:165–170PubMed Hardt PD, Kress O, Fadgyas T et al (2000) Octreotide in the prevention of pancreatic damage induced by endoscopic sphincterotomy. Eur J Med Res 5:165–170PubMed
24.
go back to reference Poon RT, Fan ST (2003) Antisecretory agents for prevention of post-ERCP pancreatitis: rationale for use and clinical results. JOP 4:33–40PubMed Poon RT, Fan ST (2003) Antisecretory agents for prevention of post-ERCP pancreatitis: rationale for use and clinical results. JOP 4:33–40PubMed
25.
go back to reference Andriulli A, Leandro G, Clemente R et al (1998) Meta-analysis of somatostatin, octreotide and gabexate mesilate in the therapy of acute pancreatitis. Aliment Pharmacol Ther 12:237–245PubMedCrossRef Andriulli A, Leandro G, Clemente R et al (1998) Meta-analysis of somatostatin, octreotide and gabexate mesilate in the therapy of acute pancreatitis. Aliment Pharmacol Ther 12:237–245PubMedCrossRef
26.
go back to reference Cavallini G, Frulloni L (2001) Somatostatin and octreotide in acute pancreatitis: the never-ending story. Dig Liver Dis 33:192–201PubMedCrossRef Cavallini G, Frulloni L (2001) Somatostatin and octreotide in acute pancreatitis: the never-ending story. Dig Liver Dis 33:192–201PubMedCrossRef
27.
go back to reference Uhl W, Buchler MW, Malfertheiner P et al (1999) A randomized, double blind, multicentric trial of octreotide in moderate to severe acute pancreatitis. Gut 45:97–104PubMed Uhl W, Buchler MW, Malfertheiner P et al (1999) A randomized, double blind, multicentric trial of octreotide in moderate to severe acute pancreatitis. Gut 45:97–104PubMed
28.
go back to reference Gouillat C, Gigot JF (2001) Pancreatic surgical complications-the case for prophylaxis. Gut 49(Suppl 4):32–39 Gouillat C, Gigot JF (2001) Pancreatic surgical complications-the case for prophylaxis. Gut 49(Suppl 4):32–39
29.
go back to reference Hesse UJ, DeDecker C, Houtmeyers P et al (2005) Prospectively randomized trial using perioperative low-dose octreotide to prevent organ-related and general complications after pancreatic surgery and pancreatico-jejunostomy. World J Surg 29:1325–1328PubMedCrossRef Hesse UJ, DeDecker C, Houtmeyers P et al (2005) Prospectively randomized trial using perioperative low-dose octreotide to prevent organ-related and general complications after pancreatic surgery and pancreatico-jejunostomy. World J Surg 29:1325–1328PubMedCrossRef
30.
go back to reference Zeng Q, Zhang Q, Han S et al (2008) Efficacy of somatostatin and its analogues in prevention of postoperative complications after pancreaticoduodenectomy: a meta-analysis of randomized controlled trials. Pancreas 36:18–25PubMedCrossRef Zeng Q, Zhang Q, Han S et al (2008) Efficacy of somatostatin and its analogues in prevention of postoperative complications after pancreaticoduodenectomy: a meta-analysis of randomized controlled trials. Pancreas 36:18–25PubMedCrossRef
31.
go back to reference Morgan KA, Adams DB (2007) Management of internal and external pancreatic fistulas. Surg Clin North Am 87:1503–1513PubMedCrossRef Morgan KA, Adams DB (2007) Management of internal and external pancreatic fistulas. Surg Clin North Am 87:1503–1513PubMedCrossRef
32.
go back to reference Vasquez JC, Coimbra R, Hoyt DB et al (2001) Management of penetrating pancreatic trauma: an 11-year experience of a level-1 trauma center. Injury 32:753–759PubMedCrossRef Vasquez JC, Coimbra R, Hoyt DB et al (2001) Management of penetrating pancreatic trauma: an 11-year experience of a level-1 trauma center. Injury 32:753–759PubMedCrossRef
33.
go back to reference O’Toole D, Vullierme MP, Ponsot P et al (2007) Diagnosis and management of pancreatic fistulae resulting in pancreatic ascites or pleural effusions in the era of helical CT and magnetic resonance imaging. Gastroenterol Clin Biol 31:686–693PubMed O’Toole D, Vullierme MP, Ponsot P et al (2007) Diagnosis and management of pancreatic fistulae resulting in pancreatic ascites or pleural effusions in the era of helical CT and magnetic resonance imaging. Gastroenterol Clin Biol 31:686–693PubMed
34.
go back to reference Uchiyama T, Suzuki T, Adachi A et al (1992) Pancreatic pleural effusion: case report and review of 113 cases in Japan. Am J Gastroenterol 87:387–391PubMed Uchiyama T, Suzuki T, Adachi A et al (1992) Pancreatic pleural effusion: case report and review of 113 cases in Japan. Am J Gastroenterol 87:387–391PubMed
35.
go back to reference Dhebri AR, Ferran N (2005) Nonsurgical management of pancreaticopleural fistula. JOP 6:152–161PubMed Dhebri AR, Ferran N (2005) Nonsurgical management of pancreaticopleural fistula. JOP 6:152–161PubMed
36.
go back to reference Amirada E, Livingston DH, Elcavage J (1994) Octreotide acetate decreases pancreatic complications after pancreatic trauma. Am J Surg 168:345–347CrossRef Amirada E, Livingston DH, Elcavage J (1994) Octreotide acetate decreases pancreatic complications after pancreatic trauma. Am J Surg 168:345–347CrossRef
37.
go back to reference Ohge H, Yokoyama T, Kodama T et al (1999) Surgical approaches for pancreatic ascites: report of three cases. Surg Today 29:458–461PubMedCrossRef Ohge H, Yokoyama T, Kodama T et al (1999) Surgical approaches for pancreatic ascites: report of three cases. Surg Today 29:458–461PubMedCrossRef
38.
go back to reference Munshi IA, Haworth R, Barie PS (1995) Resolution of refractory pancreatic ascites after continuous infusion of octreotide acetate. Int J Pancreatol 17:203–206PubMed Munshi IA, Haworth R, Barie PS (1995) Resolution of refractory pancreatic ascites after continuous infusion of octreotide acetate. Int J Pancreatol 17:203–206PubMed
39.
go back to reference Gislason H, Gronbech JE, Soreide O (1991) Pancreatic ascites: treatment by continuous somatostatin infusion. Am J Gastroenterol 86:519–521PubMed Gislason H, Gronbech JE, Soreide O (1991) Pancreatic ascites: treatment by continuous somatostatin infusion. Am J Gastroenterol 86:519–521PubMed
40.
go back to reference Lin BC, Liu NJ, Fang JF et al (2006) Long-term results of endoscopic stent in the management of blunt major pancreatic duct injury. Surg Endosc 20:1551–1555PubMedCrossRef Lin BC, Liu NJ, Fang JF et al (2006) Long-term results of endoscopic stent in the management of blunt major pancreatic duct injury. Surg Endosc 20:1551–1555PubMedCrossRef
41.
go back to reference Moore EE, Jones TN (1986) Benefits of immediate jejunostomy feeding after major abdominal trauma—a prospective randomized trial. J Trauma 26:874–881PubMedCrossRef Moore EE, Jones TN (1986) Benefits of immediate jejunostomy feeding after major abdominal trauma—a prospective randomized trial. J Trauma 26:874–881PubMedCrossRef
42.
go back to reference Kudsk KA, Croce MA, Fabian TC et al (1992) Enteral versus parenteral feeding. Effects on septic morbidity after blunt and penetrating abdominal trauma. Ann Surg 215:503–513PubMedCrossRef Kudsk KA, Croce MA, Fabian TC et al (1992) Enteral versus parenteral feeding. Effects on septic morbidity after blunt and penetrating abdominal trauma. Ann Surg 215:503–513PubMedCrossRef
43.
go back to reference Gupta R, Patel K, Calder PC et al (2003) A randomised clinical trial to assess the effect of total enteral and total parenteral nutritional support on metabolic, inflammatory and oxidative markers in patients with predicted severe acute pancreatitis (APACHE II ≥ 6). Pancreatology 3:406–413PubMedCrossRef Gupta R, Patel K, Calder PC et al (2003) A randomised clinical trial to assess the effect of total enteral and total parenteral nutritional support on metabolic, inflammatory and oxidative markers in patients with predicted severe acute pancreatitis (APACHE II ≥ 6). Pancreatology 3:406–413PubMedCrossRef
44.
go back to reference Abou-Assi S, Craig K, O’Keefe SJ (2002) Hypocaloric jejunal feeding is better than total parenteral nutrition in acute pancreatitis: results of a randomized comparative study. Am J Gastroenterol 97:2255–2262PubMedCrossRef Abou-Assi S, Craig K, O’Keefe SJ (2002) Hypocaloric jejunal feeding is better than total parenteral nutrition in acute pancreatitis: results of a randomized comparative study. Am J Gastroenterol 97:2255–2262PubMedCrossRef
45.
go back to reference Olah A, Pardavi G, Belagyi T et al (2002) Early nasojejunal feeding in acute pancreatitis is associated with a lower complication rate. Nutrition 18:259–262PubMedCrossRef Olah A, Pardavi G, Belagyi T et al (2002) Early nasojejunal feeding in acute pancreatitis is associated with a lower complication rate. Nutrition 18:259–262PubMedCrossRef
46.
go back to reference Windsor AC, Kanwar S, Li AG et al (1998) Compared with parenteral nutrition, enteral feeding attenuates the acute phase response and improves disease severity in acute pancreatitis. Gut 42:431–435PubMedCrossRef Windsor AC, Kanwar S, Li AG et al (1998) Compared with parenteral nutrition, enteral feeding attenuates the acute phase response and improves disease severity in acute pancreatitis. Gut 42:431–435PubMedCrossRef
47.
go back to reference McClave SA, Greene LM, Snider HL et al (1997) Comparison of the safety of early enteral vs parenteral nutrition in mild acute pancreatitis. JPEN J Parenter Enteral Nutr 21:14–20PubMedCrossRef McClave SA, Greene LM, Snider HL et al (1997) Comparison of the safety of early enteral vs parenteral nutrition in mild acute pancreatitis. JPEN J Parenter Enteral Nutr 21:14–20PubMedCrossRef
48.
go back to reference Kalfarentzos F, Kehagias J, Mead N et al (1997) Enteral nutrition is superior to parenteral nutrition in severe acute pancreatitis: results of a randomized prospective trial. Br J Surg 84:1665–1669PubMedCrossRef Kalfarentzos F, Kehagias J, Mead N et al (1997) Enteral nutrition is superior to parenteral nutrition in severe acute pancreatitis: results of a randomized prospective trial. Br J Surg 84:1665–1669PubMedCrossRef
Metadata
Title
Extension of Nonoperative Management of Blunt Pancreatic Trauma to Include Grade III Injuries: A Safety Analysis
Authors
Giacomo Pata
Claudio Casella
Ernesto Di Betta
Luigi Grazioli
Bruno Salerni
Publication date
01-08-2009
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 8/2009
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-009-0082-7

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