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01-10-2008

Predictive Factors of Microvascular Invasion in Patients with Hepatocellular Carcinoma Larger Than 5 cm

Authors: Yasuhiko Nagano, Hiroshi Shimada, Kazuhisa Takeda, Michio Ueda, Kenichi Matsuo, Kuniya Tanaka, Itaru Endo, Chikara Kunisaki, Shinji Togo

Published in: World Journal of Surgery | Issue 10/2008

Abstract

Background

Patients with hepatocellular carcinoma (HCC) who undergo liver resection and transplantation are predicted to have a poor outcome if the disease is associated with vascular invasion. This study aimed to identify preoperative predictors of microvascular invasion in patients with HCCs larger than 5 cm.

Methods

From May 1992 to October 2005, 231 patients underwent curative hepatic resection for HCC. Of these, 96 patients had HCCs larger than 5 cm. Analysis was limited to patients without macroscopic vascular invasion (n = 65).

Results

Multivariate analysis showed that patients with tumors larger than 7 cm and type 2 (single nodular type with extranodular growth) and type 3 (contiguous multinodular type formed by a cluster of small and contiguous nodules) tumors had an increased risk of microscopic vascular invasion. The overall incidence of microscopic vascular invasion was 46.2% (n = 30), but only 12.5% (2/16) in patients with type 1 tumors (single nodular type that is approximately round with a clear demarcation) measuring less than 7 cm.

Conclusion

Larger tumors (>7 cm) and type 2 and type 3 tumors are strong predictors of microvascular invasion in patients with HCCs larger than 5 cm.

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Title: Predictive Factors of Microvascular Invasion in Patients with Hepatocellular Carcinoma Larger Than 5 cm
Authors: Yasuhiko Nagano
Hiroshi Shimada
Kazuhisa Takeda
Michio Ueda
Kenichi Matsuo
Kuniya Tanaka
Itaru Endo
Chikara Kunisaki
Shinji Togo
Publication date: 01-10-2008
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 10/2008
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-008-9585-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Predictive Factors of Microvascular Invasion in Patients with Hepatocellular Carcinoma Larger Than 5 cm

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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