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01-01-2008

Analysis of Prognostic Factors Influencing Long-term Survival After Hepatic Resection for Metastatic Colorectal Cancer

Authors: Marcella Arru, Luca Aldrighetti, Renato Castoldi, Saverio Di Palo, Elena Orsenigo, Marco Stella, Carlo Pulitanò, Francesca Gavazzi, Gianfranco Ferla, Valerio Di Carlo, Carlo Staudacher

Published in: World Journal of Surgery | Issue 1/2008

Abstract

Background

The aim of this study was to analyze the prognostic factors associated with long-term outcome after liver resection for colorectal metastases. The retrospective analysis included 297 liver resections for colorectal metastases.

Methods

The variables considered included disease stage, differentiation grade, site and nodal metastasis of the primary tumor, number and diameter of the lesions, time from primary cancer to metastasis, preoperative carcinoembryonic antigen (CEA) level, adjuvant chemotherapy, type of resection, intraoperative ultrasonography and portal clamping use, blood loss, transfusions, complications, hospitalization, surgical margins status, and a clinical risk score (MSKCC-CRS).

Results

The univariate analysis revealed a significant difference (p < 0.05) in overall 5-year survival rates depending on the differentiation grade, preoperative CEA >5 and >200 ng/ml, diameter of the lesion >5 cm, time from primary tumor to metastases >12 months, MSKCC-CRS >2. The multivariate analysis showed three independent negative prognostic factors: G3 or G4 grade, CEA >5 ng/ml, and high MSKCC-CRS.

Conclusions

No single prognostic factor proved to be associated with a sufficiently disappointing outcome to exclude patients from liver resection. However, in the presence of some prognostic factors (G3–G4 differentiation, preoperative CEA >5 ng/ml, high MSKCC-CRS), enrollment of patients in trials exploring new adjuvant treatments is suggested to improve the outcome after surgery.

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Title: Analysis of Prognostic Factors Influencing Long-term Survival After Hepatic Resection for Metastatic Colorectal Cancer
Authors: Marcella Arru
Luca Aldrighetti
Renato Castoldi
Saverio Di Palo
Elena Orsenigo
Marco Stella
Carlo Pulitanò
Francesca Gavazzi
Gianfranco Ferla
Valerio Di Carlo
Carlo Staudacher
Publication date: 01-01-2008
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 1/2008
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-007-9285-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Analysis of Prognostic Factors Influencing Long-term Survival After Hepatic Resection for Metastatic Colorectal Cancer

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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