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Published in:

01-03-2007

Extended Resections of Liver Metastases from Colorectal Cancer

Authors: S. Jonas, MD, A. Thelen, MD, C. Benckert, MD, A. Spinelli, MD, S. Sammain, MD, U. Neumann, MD, B. Rudolph, MD, P. Neuhaus, MD

Published in: World Journal of Surgery | Issue 3/2007

Abstract

Background

Indications for resection of liver metastases from colorectal cancer and surgical strategies are still under debate.

Methods

We have retrospectively reviewed the outcome of 660 patients after 685 liver resections for metastases of colorectal cancer in our institution from 1988 to 2004. All surviving patients have a minimum follow-up period of 1 year. The longest follow-up in these patients is 16 years. Three different time periods of 5 to 6 years each were analyzed.

Results

The 30- and 60-day mortality rates were 1.5% (n = 10) and 2.2 % (n = 15), respectively. The rate of formally curative (R0) resections was 84%. Five-year survival rates in all patients and in patients after R0 resection were 37% and 42%, respectively. If only resections from 1999 to 2004 were considered, 5-year survival in patients after R0 resection was 50%. In a multivariate analysis, surgical radicality, ligamental lymph node involvement, number of liver metastases, and time period, in which the liver resection had been performed, were independent prognostic parameters.

Conclusions

Outcome after liver resection for metastases from colorectal cancer has constantly improved. A formally curative resection is the most relevant prognostic parameter. Number of liver metastases and, in the few patients concerned, lymph node infiltration of the hepatoduodenal ligament, were further prognostic parameters.

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Title: Extended Resections of Liver Metastases from Colorectal Cancer
Authors: S. Jonas, MD
A. Thelen, MD
C. Benckert, MD
A. Spinelli, MD
S. Sammain, MD
U. Neumann, MD
B. Rudolph, MD
P. Neuhaus, MD
Publication date: 01-03-2007
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 3/2007
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-006-0140-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Extended Resections of Liver Metastases from Colorectal Cancer

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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