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01-09-2003 | World Progress in Surgery

Barrett’s Esophagus: Environmental Influences in the Progression of Dysplasia

Authors: Ralph A. Boulton, M.B., Ph.D., Bernhard Usselmann, M.B., M.R.C.P., Imtiyaz Mohammed, M.B., M.R.C.P., Janusz Jankowski, M.D., Ph.D.

Published in: World Journal of Surgery | Issue 9/2003

Abstract

Barrett’s esophagus (BE) is composed of multiple lineages including Paneth cells and endocrine cells in addition to gastric and intestinal cells. Although the origin of the BE stem cell is a matter of conjecture, the stem cells are clearly multipotent, and therefore the phenotype is restricted by genomic imprinting (termed restricted potency). Recent evidence suggests that the microenvironment may select various lineages. In this regard the proportion of gastric and specialized intestinal metaplastic cells has been attributed to the composition of the refluxate, acid or bile, respectively. Experimental evidence also implicates specific xenobiotics in this process, including bile acids. In particular we discuss the potential biologic roles of bile acids in epithelial adaptation from in vivo and in vitro models.

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Title: Barrett’s Esophagus: Environmental Influences in the Progression of Dysplasia
Authors: Ralph A. Boulton, M.B., Ph.D.
Bernhard Usselmann, M.B., M.R.C.P.
Imtiyaz Mohammed, M.B., M.R.C.P.
Janusz Jankowski, M.D., Ph.D.
Publication date: 01-09-2003
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 9/2003
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-003-7054-0

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Barrett’s Esophagus: Environmental Influences in the Progression of Dysplasia

Abstract

Keynote webinar | Spotlight on medication adherence

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