Published in:
01-12-2015 | Original Article
A Meta-analysis of Postoperative Complications of Tissue Expander/Implant Breast Reconstruction Using Acellular Dermal Matrix
Authors:
Xiangyi Zhao, Xiaowei Wu, Jie Dong, Yingying Liu, Liang Zheng, Liming Zhang
Published in:
Aesthetic Plastic Surgery
|
Issue 6/2015
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Abstract
Background
Acellular dermal matrix (ADM) is commonly used for tissue expander/implant breast (TE/I-based) reconstruction. But the relation between ADM and postoperative complications remains controversial. A few meta-analyses were conducted in 2011–2012 and the result revealed that ADM can increase the risk of complications. The purpose of our study is to offer updated evidence for ADM clinical application by analyzing the effect of ADM on complications of TE/I-based breast reconstruction.
Methods
The literature published from January 2010 to February 2015 was searched in EMbase, Medline, Science Direct, the Cochrane Central Register of Controlled Trials (CENTRAL), CBMdisc, CNKI, VIP, and the references of those included studies were also searched by hand. According to inclusive criteria, 11 studies were selected and the values were extracted from the included literature. Complications with four different categories assigned for overall complications, infection, hematoma/seroma, and explantation were collected. RevMan 5.1 was used for meta-analysis. The evidence level was assessed by using the GRADE system.
Results
Eleven published studies were included. The results showed that compared to the control group, the ADM group increased the rate of overall complications (OR = 1.33, 95 % CI 1.03–1.70, p = 0.03), infection (OR = 1.47, 95 % CI 1.04–2.06, p = 0.03), hematoma/seroma (OR = 1.66, 95 % CI 1.13–2.44, p = 0.01), but there was no significant difference in explantation (OR = 1.37, 95 % CI 0.89–2.11, p = 0.15). Based on the GRADE system, all the evidence was at level C and weak recommendation.
Conclusions
In TE/I-based breast reconstruction, ADM increased the incidence of overall complications, infection, and hematoma/seroma; the incidence of explantation remains unknown. For the poor quality of the original studies, a prudent choice is suggested; and more high-quality, large-sample studies are needed.
No Level Assigned
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http://www.springer.com/00266.