Top

Published in:

01-08-2015 | Review

Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature

Authors: Anthony P. Sclafani, James Azzi

Published in: Aesthetic Plastic Surgery | Issue 4/2015

Abstract

In facial plastic surgery, the potential for direct delivery of growth factors from platelet preparations has been of particular interest for use in facial rejuvenation, recovery after facial surgery, and wound healing. A literature search was conducted through PubMed for the terms PRP, PRFM, platelet-rich plasma, platelet-rich fibrin matrix, platelet preparations, platelet therapy, growth factors, platelet facial, platelet facial rejuvenation, platelet wound healing, platelet plastic surgery. Articles pertaining to the use of platelet preparations in facial surgery and wound healing in plastic surgery after 2001 were included. Thirteen in vitro studies showed use of platelet-rich plasma (PRP) and platelet-rich fibrin matrix (PRFM) had a significant effect on cellular activity. Twenty-four out of 28 animal studies exhibited favorable results with use of a platelet preparation, including five of six studies that showed enhanced fat graft survival with addition of a platelet preparation. Twenty-three case series and clinical trials were identified, only two of which showed no differences. Twenty-one reported favorable results with use of various platelet preparations. A total of 47 studies used PRP, four studies evaluated Leukocyte-rich PRP, and fourteen studies used PRFM. The vast majority of studies examined show a significant and measurable effect on cellular changes, wound healing, and facial esthetic outcomes with use of platelet preparations, both topical and injectable. One must also consider possible publication bias against null results that may have had an influence on the data that were available for review. However, the preponderance of studies suggests that platelet preparations might represent an as-of-yet untapped adjunct in facial plastic surgery.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Sclafani AP, Romo T III, Ukrainsky G et al (2005) Modulation of wound response and soft tissue ingrowth in synthetic and allogeneic implants with platelet concentrate. Arch Facial Plast Surg 7:163–169PubMedCrossRef

Sclafani AP, McCormick SA (2012) Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix. Arch Facial Plast Surg 14(2):132–136PubMedCrossRef

Sclafani AP (2011) Safety, efficacy, and utility of platelet-rich fibrin matrix in facial plastic surgery. Arch Facial Plast Surg 13(4):247–251PubMedCrossRef

Rughetti A, Giusti I, D’Ascenzo S et al (2008) Platelet gel-released supernatant modulates the angiogenic capability of human endothelial cells. Blood Transfus 6(1):12–17PubMedCentralPubMed

Kakudo N, Minakata T, Mitsui T, Kushida S, Notodihardjo FZ, Kusumoto K (2008) Proliferation-promoting effect of platelet-rich plasma on human adipose-derived stem cells and human dermal fibroblasts. Plast Reconstr Surg 122(5):1352–1360PubMedCrossRef

Kakudo N, Morimoto N, Kushida S, Ogawa T, Kusumoto K (2014) Platelet-rich plasma releasate promotes angiogenesis in vitro and in vivo. Med Mol Morphol 47(2):83–89PubMedCrossRef

Giusti I, Rughetti A, D’Ascenzo S et al (2009) Identification of an optimal concentration of platelet gel for promoting angiogenesis in human endothelial cells. Transfusion 49(4):771–778PubMedCrossRef

Mishra A, Tummala P, King A et al (2009) Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation. Tissue Eng Part C 15(3):431–435CrossRef

Kushida S, Kakudo N, Suzuki K, Kusumoto K (2013) Effects of platelet-rich plasma on proliferation and myofibroblastic differentiation in human dermal fibroblasts. Ann Plast Surg 71(2):219–224PubMedCrossRef

10.

Kim DH, Je YJ, Kim CD et al (2011) Can platelet-rich plasma be used for skin rejuvenation? evaluation of effects of platelet-rich plasma on human dermal fibroblast. Ann Dermatol 23(4):424–431PubMedCentralPubMedCrossRef

11.

Tajima S, Tobita M, Orbay H, Hyakusoku H, Mizuno H (2015) Direct and indirect effects on bone regeneration of a combination of adipose-derived stem cells and platelet-rich plasma. Tissue Eng Part A 21(5–6):895–905PubMedCrossRef

12.

Atashi F, Jaconi ME, Pittet-Cuenod B, Modarressi A (2015) Autologous platelet-rich plasma: a biological supplement to enhance adipose-derived mesenchymal stem cell expansion. Tissue Eng Part C 21(3):253–262CrossRef

13.

Amable PR, Teixeira MV, Carias RB, Granjeiro JM, Borojevic R (2014) Mesenchymal stromal cell proliferation, gene expression and protein production in human platelet-rich plasma-supplemented media. PLoS ONE 9(8):e104662. doi:10.1371/journal.pone.0104662 PubMedCentralPubMedCrossRef

14.

Shin MK, Lee JW, Kim YI, Kim YO, Seok H, Kim NI (2014) The effects of platelet-rich clot releasate on the expression of MMP-1 and type I collagen in human adult dermal fibroblasts: PRP is a stronger MMP-1 stimulator. Mol Biol Rep 41(1):3–8PubMedCrossRef

15.

Roubelakis MG, Trohatou O, Roubelakis A et al (2014) Platelet-rich plasma (PRP) promotes fetal mesenchymal stem/stromal cell migration and wound healing process. Stem Cell Rev 10(3):417–428PubMedCrossRef

16.

Farrag TY, Lehar M, Verhaegen P, Carson KA, Byrne PJ (2007) Effect of platelet rich plasma and fibrin sealant on facial nerve regeneration in a rat model. Laryngoscope 117(1):157–165PubMedCrossRef

17.

Cho JM, Lee YH, Baek RM, Lee SW (2011) Effect of platelet-rich plasma on ultraviolet b-induced skin wrinkles in nude mice. J Plast Reconstr Aesthet Surg 64(2):e31–e39PubMedCrossRef

18.

Oh DS, Cheon YW, Jeon YR, Lew DH (2011) Activated platelet-rich plasma improves fat graft survival in nude mice: a pilot study. Dermatol Surg 37(5):619–625PubMedCrossRef

19.

Pires Fraga MF, Nishio RT, Ishikawa RS et al (2010) Increased survival of free fat grafts with platelet-rich plasma in rabbits. J Plast Reconstr Aesthet Surg 63(12):e818–e822PubMedCrossRef

20.

Nakamura S, Ishihara M, Takikawa M et al (2010) Platelet-rich plasma (PRP) promotes survival of fat-grafts in rats. Ann Plast Surg 65(1):101–106PubMedCrossRef

21.

Rodríguez-Flores J, Palomar-Gallego MA, Enguita-Valls AB, Rodriguez-Peralto JL, Torres J (2011) Influence of platelet-rich plasma on the histologic characteristics of the autologous fat graft to the upper lip of rabbits. Aesthetic Plast Surg 35(4):480–486PubMedCrossRef

22.

Li K, Li F, Li J et al (2014) Increased survival of human free fat grafts with varying densities of human adipose-derived stem cells and platelet-rich plasma. J Tissue Eng Regen Med. doi:10.1002/term.1903

23.

Por YC, Yeow VK, Louri N et al (2009) Platelet-rich plasma has no effect on increasing free fat graft survival in the nude mouse. J Plast Reconstr Aesthet Surg 62(8):1030–1034PubMedCrossRef

24.

Chandra RK, Handorf C, West M, Kruger EA, Jackson S (2007) Histologic effects of autologous platelet gel in skin flap healing. Arch Facial Plast Surg 9(4):260–263PubMedCrossRef

25.

Jeon YR, Kang EH, Yang CE et al (2014) The effect of platelet-rich plasma on composite graft survival. Plast Reconstr Surg 134(2):239–246PubMedCrossRef

26.

Liu HY, Huang CF, Lin TC et al (2014) Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma. Biomaterials 35(37):9767–9776PubMedCrossRef

27.

Notodihardjo PV, Morimoto N, Kakudo N et al (2015) Gelatin hydrogel impregnated with platelet-rich plasma releasate promotes angiogenesis and wound healing in murine model. J Artif Organs 18(1):64–71PubMedCrossRef

28.

Takabayashi Y, Ishihara M, Sumi Y et al (2015) Platelet-rich plasma-containing fragmin-protamine micro-nanoparticles promote epithelialization and angiogenesis in split-thickness skin graft donor sites. J Surg Res 193(1):483–491PubMedCrossRef

29.

Sevim KZ, Yazar M, Irmak F et al (2014) Use of platelet-rich plasma solution applied with composite chondrocutaneous graft technique: an experimental study in rabbit model. J Oral Maxillofac Surg 72(7):1407–1419PubMedCrossRef

30.

Kim HY, Park JH, Han YS, Kim H (2013) The effect of platelet-rich plasma on flap survival in random extension of an axial pattern flap in rabbits. Plast Reconstr Surg 132(1):85–92PubMedCrossRef

31.

Zheng C, Zhu Q, Liu X et al (2014) Improved peripheral nerve regeneration using acellular nerve allografts loaded with platelet-rich plasma. Tissue Eng Part A 20(23–24):3228–3240PubMedCrossRef

32.

Miao Y, Sun YB, Sun XJ et al (2013) Promotional effect of platelet-rich plasma on hair follicle reconstitution in vivo. Dermatol Surg 39(12):1868–1876PubMedCrossRef

33.

Kawazoe T, Kim HH (2012) Tissue augmentation by white blood cell-containing platelet-rich plasma. Cell Transpl 21(2–3):601–607CrossRef

34.

Giovanini AF, Grossi JR, Gonzaga CC et al (2014) Leukocyte-platelet-rich plasma (L-PRP) induces an abnormal histophenotype in craniofacial bone repair associated with changes in the immunopositivity of the hematopoietic clusters of differentiation, osteoproteins, and TGF-β1. Clin Implant Dent Relat Res 16(2):259–272PubMedCrossRef

35.

Giovanini AF, Deliberador TM, Gonzaga CC et al (2010) Platelet-rich plasma diminishes calvarial bone repair associated with alterations in collagen matrix composition and elevated CD34 + cell prevalence. Bone 46(6):1597–1603PubMedCrossRef

36.

Giovanini AF, Gonzaga CC, Zielak JC et al (2011) Platelet-rich plasma (PRP) impairs the craniofacial bone repair associated with its elevated TGF-β levels and modulates the co-expression between collagen III and α-smooth muscle actin. J Orthop Res 29(3):457–463PubMedCrossRef

37.

Giovanini AF, Deliberador TM, Tannuri Nemeth JE et al (2013) Leukocyte-platelet-rich plasma (L-PRP) impairs the osteoconductive capacity of the autograft associated to changes in the immunolocalization of TGF-β1 and its co-expression with Wnt10b and CD34 cells. J Craniomaxillofac Surg 41(7):e180–e186PubMedCrossRef

38.

Chen Y, Niu Z, Xue Y et al (2014) Improvement in the repair of defects in maxillofacial soft tissue in irradiated minipigs by a mixture of adipose-derived stem cells and platelet-rich fibrin. Br J Oral Maxillofac Surg 52(8):740–745PubMedCrossRef

39.

Kim TH, Kim SH, Sandor GK, Kim YD (2014) Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing. Arch Oral Biol 59(5):550–558PubMedCrossRef

40.

Reksodiputro M, Widodo D, Bashiruddin J, Siregar N, Malik S (2014) PRFM enhance wound healing process in skin graft. Facial Plast Surg 30(6):670–675PubMedCrossRef

41.

Powell DM, Chang E, Farrior EH (2001) Recovery from deep-plane rhytidectomy following unilateral wound treatment with autologous platelet gel: a pilot study. Arch Facial Plast Surg 3:245–250PubMedCrossRef

42.

Hom DB, Linzie BM, Huang TC (2007) The healing effects of autologous platelet gel on acute human skin wounds. Arch Facial Plast Surg 9:174–183PubMedCrossRef

43.

Danielsen P, Jorgensen B, Karlsmark T, Jorgensen LN, Agren MS (2008) Effect of topical autologous platelet-rich fibrin versus no intervention on epithelialization of donor sites and meshed split-thickness skin autografts: a randomized clinical trial. Plast Reconstr Surg 122:1431–1440PubMedCrossRef

44.

Danielsen PL, Agren MS, Jorgensen LN (2010) Platelet-rich fibrin versus albumin in surgical wound repair: a randomized trial with paired design. Ann Surg 251(5):825–831PubMedCrossRef

45.

Kakudo N, Kushida S, Minakata T, Suzuki K, Kusumoto K (2011) Platelet-rich plasma promotes epithelialization and angiogenesis in a splitthickness skin graft donor site. Med Mol Morphol 44(4):233–236PubMedCrossRef

46.

Yuksel EP, Sahin G, Aydin F, Senturk N, Turanli AY (2014) Evaluation of effects of platelet-rich plasma on human facial skin. J Cosmet Laser Ther 16(5):206–208PubMedCrossRef

47.

Mehryan P, Zartab H, Rajabi A, Pazhoohi N, Firooz A (2014) Assessment of efficacy of platelet-rich plasma (PRP) on infraorbital dark circles and crow’s feet wrinkles. J Cosmet Dermatol 13(1):72–78PubMedCrossRef

48.

Willemsen JC, van der Lei B, Vermeulen KM, Stevens HP (2014) The effects of platelet-rich plasma on recovery time and aesthetic outcome in facial rejuvenation: preliminary retrospective observations. Aesthetic Plast Surg 38(5):1057–1063PubMedCrossRef

49.

Redaelli A, Romano D, Marciano A (2010) Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol 9(5):466–472PubMed

50.

Sclafani AP (2010) Platelet-rich fibrin matrix for improvement of deep nasolabial folds. J Cosmet Dermatol 9(1):66–71PubMedCrossRef

51.

Gentile P, De Angelis B, Pasin M et al (2014) Adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical evaluation for cell-based therapies in patients with scars on the face. J Craniofac Surg 25(1):267–272PubMedCrossRef

52.

Lee JW, Kim BJ, Kim MN, Mun SK (2011) The efficacy of autologous platelet rich plasma combined with ablative carbon dioxide fractional resurfacing for acne scars: a simultaneous split-face trial. Dermatol Surg 37(7):931–938PubMedCrossRef

53.

Gawdat HI, Hegazy RA, Fawzy MM, Fathy M (2014) Autologous platelet rich plasma: topical versus intradermal after fractional ablative carbon dioxide laser treatment of atrophic acne scars. Dermatol Surg 40(2):152–161PubMedCrossRef

54.

Na JI, Choi JW, Choi HR et al (2011) Rapid healing and reduced erythema after ablative fractional carbon dioxide laser resurfacing combined with the application of autologous platelet-rich plasma. Dermatol Surg 37(4):463–468PubMedCrossRef

55.

Shin MK, Lee JH, Lee SJ, Kim NI (2012) Platelet-rich plasma combined with fractional laser therapy for skin rejuvenation. Dermatol Surg 38(4):623–630PubMedCrossRef

56.

Kim H, Gallo J (2015) Evaluation of the effect of platelet-rich plasma on recovery after ablative fractional photothermolysis. JAMA Facial Plast Surg 17(2):97–102PubMedCrossRef

57.

Chignon-Sicard B, Georgiou CA, Fontas E et al (2012) Efficacy of leukocyte- and platelet-rich fibrin in wound healing: a randomized controlled clinical trial. Plast Reconstr Surg 130(6):819e–829ePubMedCrossRef

58.

Sclafani AP (2014) Platelet-rich fibrin matrix (PRFM) for androgenetic alopecia. Facial Plast Surg 30(2):219–224PubMedCrossRef

59.

Schiavone G, Raskovic D, Greco J, Abeni D (2014) Platelet-rich plasma for androgenetic alopecia: a pilot study. Dermatol Surg 40(9):1010–1019PubMedCrossRef

60.

Cervelli V, Garcovich S, Bielli A et al (2014) The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation. Biomed Res Int. doi:10.1155/2014/760709

61.

Khatu SS, More YE, Gokhale NR, Chavhan DC, Bendsure N (2014) Platelet-rich plasma in androgenic alopecia: myth or an effective tool. J Cutan Aesthet Surg 7(2):107–110PubMedCentralPubMedCrossRef

Title: Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature
Authors: Anthony P. Sclafani
James Azzi
Publication date: 01-08-2015
Publisher: Springer US
Published in: Aesthetic Plastic Surgery / Issue 4/2015
Print ISSN: 0364-216X
Electronic ISSN: 1432-5241
DOI: https://doi.org/10.1007/s00266-015-0504-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature

Abstract

Level of Evidence V

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Level of Evidence V

Please log in to get access to this content

Other articles of this Issue 4/2015

An Experimental Study of Auricular Reconstruction Using a Thin Porous Silastic Frame Assisted by Tissue Expansion: An Animal Study

Bio-Revitalization: Effects of NASHA on Genes Involving Tissue Remodeling

Patient-Report Satisfaction and Health-Related Quality of Life in TiLOOP® Bra-Assisted or Implant-Based Breast Reconstruction Alone

Comparison of Various Rhinoplasty Techniques and Long-Term Results

Vaginal Rejuvenation with Gore-Mycromesh

Allogeneic Adipose-Derived Stem Cells Protect Fat Grafts at the Early Stage and Improve Long-Term Retention in Immunocompetent Rats