Skip to main content
Top
Published in: International Orthopaedics 1/2021

01-01-2021 | COVID-19 | Original Paper

Thirty-day mortality following surgical management of hip fractures during the COVID-19 pandemic: findings from a prospective multi-centre UK study

Authors: A. Narang, G. Chan, A. Aframian, Z. Ali, A. Carr, H. Goodier, C. Morgan, C. Park, K. Sugand, T. Walton, M. Wilson, A. Belgaumkar, K. Gallagher, K. Ghosh, C. Gibbons, A. Keightley, Z. Nawaz, C. Wakeling, K. Sarraf, B. A. Rogers, W. K. M. Kieffer

Published in: International Orthopaedics | Issue 1/2021

Login to get access

Abstract

Purpose

Thirty-day mortality of patients with hip fracture is well researched and predictive; validated scoring tools have been developed (Nottingham Hip Fracture Score, NHFS). COVID-19 has significantly greater mortality in the elderly and comorbid patients which includes hip fracture patients. Non-operative treatment is not appropriate due to significantly higher mortality, and therefore, these patients are often exposed to COVID-19 in the peri-operative period. What is unclear is the effect of concomitant COVID-19 infection in these patients.

Methods

A multicentre prospective study across ten sites in the United Kingdom (responsible for 7% of hip fracture patients per annum in the UK). Demographic and background information were collected by independent chart review. Data on surgical factors included American Society of Anesthesiologists (ASA) score, time to theatre, Nottingham Hip fracture score (NHFS) and classification of fracture were also collected between 1st March 2020 and 30th April 2020 with a matched cohort from the same period in 2019.

Results

Actual and expected 30-day mortality was found to be significantly higher than expected for 2020 COVID-19 positive patients (RR 3.00 95% CI 1.57–5.75, p < 0.001), with 30 observed deaths compared against the 10 expected from NHFS risk stratification.

Conclusion

COVID-19 infection appears to be an independent risk factor for increased mortality in hip fracture patients. Whilst non-operative management of these fractures is not suggested due to the documented increased risks and mortality, this study provides evidence to the emerging literature of the severity of COVID-19 infection in surgical patients and the potential impact of COVID-19 on elective surgical patients in the peri-operative period.
Appendix
Available only for authorised users
Literature
4.
go back to reference Tinetti ME, Speechley M, Ginter SF (1988) Risk factors for falls among elderly persons living in the community. N Engl J Med 29;319(26):1701–1707 Tinetti ME, Speechley M, Ginter SF (1988) Risk factors for falls among elderly persons living in the community. N Engl J Med 29;319(26):1701–1707
6.
go back to reference Klestil T, Röder C, Stotter C, Winkler B, Nehrer S, Lutz M, Klerings I, Wagner G, Gartlehner G, Nussbaumer-Streit B (2018) Impact of timing of surgery in elderly hip fracture patients: a systematic review and meta-analysis. Sci Rep 17;8(1):1–5 Klestil T, Röder C, Stotter C, Winkler B, Nehrer S, Lutz M, Klerings I, Wagner G, Gartlehner G, Nussbaumer-Streit B (2018) Impact of timing of surgery in elderly hip fracture patients: a systematic review and meta-analysis. Sci Rep 17;8(1):1–5
7.
go back to reference Healthcare Quality Improvement Partnership (2020) NHFD 2019 Annual Report. [online] Available at: [Accessed 10 May 2020] Healthcare Quality Improvement Partnership (2020) NHFD 2019 Annual Report. [online] Available at: [Accessed 10 May 2020]
8.
go back to reference Chlebeck JD, Birch CE, Blankstein M, Kristiansen T, Bartlett CS, Schottel PC (2019) Nonoperative geriatric hip fracture treatment is associated with increased mortality: a matched cohort study. J Orthop Trauma. 1;33(7):346–350 Chlebeck JD, Birch CE, Blankstein M, Kristiansen T, Bartlett CS, Schottel PC (2019) Nonoperative geriatric hip fracture treatment is associated with increased mortality: a matched cohort study. J Orthop Trauma. 1;33(7):346–350
9.
go back to reference van de Ree CL, De Jongh MA, Peeters CM, de Munter L, Roukema JA, Gosens T (2017) Hip fractures in elderly people: surgery or no surgery? A systematic review and meta-analysis. Geriatr Orthop Surg Rehabil 8(3):173–180CrossRef van de Ree CL, De Jongh MA, Peeters CM, de Munter L, Roukema JA, Gosens T (2017) Hip fractures in elderly people: surgery or no surgery? A systematic review and meta-analysis. Geriatr Orthop Surg Rehabil 8(3):173–180CrossRef
10.
go back to reference Pincus D, Ravi B, Wasserstein D, Huang A, Paterson JM, Nathens AB, Kreder HJ, Jenkinson RJ, Wodchis WP. (2017) Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. JAMA. 28;318(20):1994–2003 Pincus D, Ravi B, Wasserstein D, Huang A, Paterson JM, Nathens AB, Kreder HJ, Jenkinson RJ, Wodchis WP. (2017) Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. JAMA. 28;318(20):1994–2003
11.
go back to reference Wiles MD, Moran CG, Sahota O, Moppett IK (2011) Nottingham Hip Fracture Score as a predictor of one year mortality in patients undergoing surgical repair of fractured neck of femur. Br J Anaesth, 1;106(4):501–504 Wiles MD, Moran CG, Sahota O, Moppett IK (2011) Nottingham Hip Fracture Score as a predictor of one year mortality in patients undergoing surgical repair of fractured neck of femur. Br J Anaesth, 1;106(4):501–504
12.
go back to reference Maxwell MJ, Moran CG, Moppett IK (2008) Development and validation of a preoperative scoring system to predict 30 day mortality in patients undergoing hip fracture surgery. Br J Anaesth 101:511–517CrossRef Maxwell MJ, Moran CG, Moppett IK (2008) Development and validation of a preoperative scoring system to predict 30 day mortality in patients undergoing hip fracture surgery. Br J Anaesth 101:511–517CrossRef
13.
go back to reference Moppett IK, Parker M, Griffiths R et al (2012) Nottingham Hip Fracture Score: longitudinal and multi-centre assessment. Br J Anaesth 109:546–550CrossRef Moppett IK, Parker M, Griffiths R et al (2012) Nottingham Hip Fracture Score: longitudinal and multi-centre assessment. Br J Anaesth 109:546–550CrossRef
14.
go back to reference Cronin M, Mullins M, Pathmanaban P, Williams P, Dodd M (2020) COVID-19 causes a SHiFT in the sands for proximal femoral fracture management? The Transient Journal of Trauma, Orthopaedics and the Coronavirus 14 Cronin M, Mullins M, Pathmanaban P, Williams P, Dodd M (2020) COVID-19 causes a SHiFT in the sands for proximal femoral fracture management? The Transient Journal of Trauma, Orthopaedics and the Coronavirus 14
17.
go back to reference World Health Organization (2019) World Health Organization. Report of the who-china joint mission on coronavirus disease (COVID-19) World Health Organization (2019) World Health Organization. Report of the who-china joint mission on coronavirus disease (COVID-19)
19.
go back to reference Nepogodiev D, Glasbey JC, Li E, Omar OM, Simoes JF, Abbott TE, Alser O, Arnaud AP, Bankhead-Kendall BK, Breen KA, Cunha MF (2020) Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. The Lancet. May 29. [Epub ahead of print] Nepogodiev D, Glasbey JC, Li E, Omar OM, Simoes JF, Abbott TE, Alser O, Arnaud AP, Bankhead-Kendall BK, Breen KA, Cunha MF (2020) Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. The Lancet. May 29. [Epub ahead of print]
20.
go back to reference Muñoz Vives JM, Jornet-Gibert M, Cámara-Cabrera J, Esteban PL, Brunet L, Delgado-Flores L, Camacho-Carrasco P, Torner P, Marcano-Fernández F (2020) Spanish HIP-COVID-19 investigation group. Mortality rates of patients with proximal femoral fracture in a worldwide pandemic: preliminary results of the spanish HIP-COVID-19 observational study. J Bone Joint Surg Am. 6. https://doi.org/10.2106/JBJS.20.00686. [Epub ahead of print] PubMed PMID: 32379104 Muñoz Vives JM, Jornet-Gibert M, Cámara-Cabrera J, Esteban PL, Brunet L, Delgado-Flores L, Camacho-Carrasco P, Torner P, Marcano-Fernández F (2020) Spanish HIP-COVID-19 investigation group. Mortality rates of patients with proximal femoral fracture in a worldwide pandemic: preliminary results of the spanish HIP-COVID-19 observational study. J Bone Joint Surg Am. 6. https://​doi.​org/​10.​2106/​JBJS.​20.​00686. [Epub ahead of print] PubMed PMID: 32379104
21.
go back to reference Maniscalco P, Poggiali E, Quattrini F, Ciatti C, Magnacavallo A, Vercelli A, Domenichini M, Vaienti E, Pogliacomi F, Ceccarelli F (2020) Proximal femur fractures in COVID-19 emergency: the experience of two Orthopedics and Traumatology Departments in the first eight weeks of the Italian epidemic. Acta Bio Med [Internet] Maniscalco P, Poggiali E, Quattrini F, Ciatti C, Magnacavallo A, Vercelli A, Domenichini M, Vaienti E, Pogliacomi F, Ceccarelli F (2020) Proximal femur fractures in COVID-19 emergency: the experience of two Orthopedics and Traumatology Departments in the first eight weeks of the Italian epidemic. Acta Bio Med [Internet]
22.
go back to reference NHFD Assessment benchmark summary 2019 - South East [Internet]. Nhfd.co.uk. 2020 [cited 7 June 2020]. Available from: https://www.nhfd.co.uk/20/NHFDcharts.nsf/fmbenchmarks?readform&report=assessment&year=2019®ion=South%20East NHFD Assessment benchmark summary 2019 - South East [Internet]. Nhfd.co.uk. 2020 [cited 7 June 2020]. Available from: https://​www.​nhfd.​co.​uk/​20/​NHFDcharts.​nsf/​fmbenchmarks?​readform&​report=​assessment&​year=​2019®ion=​South%20East
27.
go back to reference Berstock JR, Beswick AD, Lenguerrand E, Whitehouse MR, Blom AW (2014) Mortality after total hip replacement surgery: a systematic review. Bone Joint Res 3(6):175–182 Berstock JR, Beswick AD, Lenguerrand E, Whitehouse MR, Blom AW (2014) Mortality after total hip replacement surgery: a systematic review. Bone Joint Res 3(6):175–182
Metadata
Title
Thirty-day mortality following surgical management of hip fractures during the COVID-19 pandemic: findings from a prospective multi-centre UK study
Authors
A. Narang
G. Chan
A. Aframian
Z. Ali
A. Carr
H. Goodier
C. Morgan
C. Park
K. Sugand
T. Walton
M. Wilson
A. Belgaumkar
K. Gallagher
K. Ghosh
C. Gibbons
A. Keightley
Z. Nawaz
C. Wakeling
K. Sarraf
B. A. Rogers
W. K. M. Kieffer
Publication date
01-01-2021
Publisher
Springer Berlin Heidelberg
Keyword
COVID-19
Published in
International Orthopaedics / Issue 1/2021
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-020-04739-y

Other articles of this Issue 1/2021

International Orthopaedics 1/2021 Go to the issue