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01-05-2016 | Original Paper

Testing of antibiotic releasing implant coatings to fight bacteria in combat-associated osteomyelitis – an in-vitro study

Authors: David Alexander Back, Nicole Bormann, Arash Calafi, Julie Zech, Leif Alexander Garbe, Martin Müller, Christian Willy, Gerhard Schmidmaier, Britt Wildemann

Published in: International Orthopaedics | Issue 5/2016

Abstract

Purpose

Surgical procedures to prevent osteomyelitis after trauma can be supported by local application of antibiotics. This in-vitro study investigated the release and impact of antibiotics from implant coatings against bacteria associated with combat-related osteomyelitis.

Methods

K-wires were coated with poly(D,L-lactide) and ciprofloxacin, gentamicin, colistin, daptomycin or cefoxitin in different concentrations. The release was quantified and antimicrobial activity tested for different gram-positive or gram-negative bacteria, alone and in combination. To exclude toxic effects, primary osteoblast-like cells were exposed to antibiotic coating concentrations.

Results

All antibiotics alone and in combination showed an initial burst release with dose dependent antimicrobial activity and no negative effects on osteoblast-like cells, except for cefoxitin.

Conclusions

Implant coatings can be customized with single or double antibiotic coatings to effectively fight different bacteria and also mixed infections in the treatment of a combat-acquired osteomyelitis. However, optimal drug load and degradation behaviour of individual antibiotics have to be considered.

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Title: Testing of antibiotic releasing implant coatings to fight bacteria in combat-associated osteomyelitis – an in-vitro study
Authors: David Alexander Back
Nicole Bormann
Arash Calafi
Julie Zech
Leif Alexander Garbe
Martin Müller
Christian Willy
Gerhard Schmidmaier
Britt Wildemann
Publication date: 01-05-2016
Publisher: Springer Berlin Heidelberg
Published in: International Orthopaedics / Issue 5/2016
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-016-3142-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Testing of antibiotic releasing implant coatings to fight bacteria in combat-associated osteomyelitis – an in-vitro study

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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