Skip to main content
Top
Published in: International Orthopaedics 10/2011

01-10-2011 | Original Paper

Is ossification of posterior longitudinal ligament an enthesopathy?

Authors: Jian Chen, Dianwen Song, Xinwei Wang, Xiaolong Shen, Yang Li, Wen Yuan

Published in: International Orthopaedics | Issue 10/2011

Login to get access

Abstract

The purpose of this study was to investigate the relationship of ossification of posterior longitudinal ligament (OPLL) with enthesis, the site where the posterior longitudinal ligament (PLL) attaches to the vertebral body, by multi-detector CT reconstruction images. Twenty-nine patients with OPLL were studied. According to the plaques’ continuity to the vertebral body, OPLL plaques were classified into two categories: “free” and “contiguous”. A “broken sign” was defined as a crack between two plaques. The sites where each “contiguous” plaque attached to the vertebral body were then analysed. There were 78 ossified plaques in total, and six were “free”. There were eight cases with a “broken sign”, including six “free” ones. The site where all 72 “contiguous” plaques attached to the vertebral body included the zone where the PLL enthesis was situated, while other zones were included in only part of the plaques. Our conclusion was that there might be no real “free type” ossified plaques, and OPLL could start from enthesis, which indicated OPLL could be a kind of enthesopathy.
Literature
1.
go back to reference Terayama K, Maruyama S, Miyashita R, Minai K, Kinoshita M, Shimizu Y (1964) Ossification of the posterior longitudinal ligament in the cervical spine. Orthop Surg 15:1083–1095 (in Japanese) Terayama K, Maruyama S, Miyashita R, Minai K, Kinoshita M, Shimizu Y (1964) Ossification of the posterior longitudinal ligament in the cervical spine. Orthop Surg 15:1083–1095 (in Japanese)
2.
go back to reference Sakou T, Matsunaga S, Koga H (2000) Recent progress in the study of pathogenesis of ossification of the posterior longitudinal ligament. J Orthop Sci 5:310–315PubMedCrossRef Sakou T, Matsunaga S, Koga H (2000) Recent progress in the study of pathogenesis of ossification of the posterior longitudinal ligament. J Orthop Sci 5:310–315PubMedCrossRef
3.
go back to reference Schmidt MH, Quinones-Hinojosa A, Rosenberg WS (2002) Cervical myelopathy associated with degenerative spine disease and ossification of the posterior longitudinal ligament. Semin Neurol 22:143–148PubMedCrossRef Schmidt MH, Quinones-Hinojosa A, Rosenberg WS (2002) Cervical myelopathy associated with degenerative spine disease and ossification of the posterior longitudinal ligament. Semin Neurol 22:143–148PubMedCrossRef
4.
go back to reference Chen Y, Chen D, Wang X et al (2009) Anterior corpectomy and fusion for severe ossification of posterior longitudinal ligament in the cervical spine. Int Orthop 33:477–482PubMedCrossRef Chen Y, Chen D, Wang X et al (2009) Anterior corpectomy and fusion for severe ossification of posterior longitudinal ligament in the cervical spine. Int Orthop 33:477–482PubMedCrossRef
5.
go back to reference Cho JL, Park YS, Kim YH (1999) Tetraparesis associated with ossification of the posterior longitudinal ligament of the cervical spine. Int Orthop 23:247–248PubMedCrossRef Cho JL, Park YS, Kim YH (1999) Tetraparesis associated with ossification of the posterior longitudinal ligament of the cervical spine. Int Orthop 23:247–248PubMedCrossRef
6.
go back to reference Hori T, Kawaguchi Y, Kimura T (2006) How does the ossification area of the posterior longitudinal ligament progress after cervical laminoplasty? Spine 31:2807–2812PubMedCrossRef Hori T, Kawaguchi Y, Kimura T (2006) How does the ossification area of the posterior longitudinal ligament progress after cervical laminoplasty? Spine 31:2807–2812PubMedCrossRef
7.
go back to reference Hori T, Kawaguchi Y, Kimura T (2007) How does the ossification area of the posterior longitudinal ligament thicken following cervical laminoplasty? Spine 32:E551–556PubMedCrossRef Hori T, Kawaguchi Y, Kimura T (2007) How does the ossification area of the posterior longitudinal ligament thicken following cervical laminoplasty? Spine 32:E551–556PubMedCrossRef
8.
go back to reference Matsunaga S, Nakamura K, Seichi A, Yokoyama T, Toh S, Ichimura S, Satomi K, Endo K, Yamamoto K, Kato Y, Ito T, Tokuhashi Y, Uchida K, Baba H, Kawahara N, Tomita K, Matsuyama Y, Ishiguro N, Iwasaki M, Yoshikawa H, Yonenobu K, Kawakami M, Yoshida M, Inoue S, Tani T, Kaneko K, Taguchi T, Imakiire T, Komiya S (2008) Radiographic predictors for the development of myelopathy in patients with ossification of the posterior longitudinal ligament: A multicenter cohort study. Spine 33:2648–2650PubMedCrossRef Matsunaga S, Nakamura K, Seichi A, Yokoyama T, Toh S, Ichimura S, Satomi K, Endo K, Yamamoto K, Kato Y, Ito T, Tokuhashi Y, Uchida K, Baba H, Kawahara N, Tomita K, Matsuyama Y, Ishiguro N, Iwasaki M, Yoshikawa H, Yonenobu K, Kawakami M, Yoshida M, Inoue S, Tani T, Kaneko K, Taguchi T, Imakiire T, Komiya S (2008) Radiographic predictors for the development of myelopathy in patients with ossification of the posterior longitudinal ligament: A multicenter cohort study. Spine 33:2648–2650PubMedCrossRef
9.
go back to reference Benjamin M, Toumi H, Ralphs JR, Bydder G, Best TM, Milz S (2006) Where tendons and ligaments meet bone: attachment sites ('entheses') in relation to exercise and/or mechanical load. J Anat 208:471–490PubMedCrossRef Benjamin M, Toumi H, Ralphs JR, Bydder G, Best TM, Milz S (2006) Where tendons and ligaments meet bone: attachment sites ('entheses') in relation to exercise and/or mechanical load. J Anat 208:471–490PubMedCrossRef
10.
go back to reference Benjamin M, McGonagle D (2001) The anatomical basis for disease localisation in seronegative spondyloarthropathy at entheses and related sites. J Anat 199:503–526PubMedCrossRef Benjamin M, McGonagle D (2001) The anatomical basis for disease localisation in seronegative spondyloarthropathy at entheses and related sites. J Anat 199:503–526PubMedCrossRef
11.
go back to reference Loughenbury PR, Wadhwani S, Soames RW (2006) The posterior longitudinal ligament and peridural (epidural) membrane. Clinical Anat 19:487–492CrossRef Loughenbury PR, Wadhwani S, Soames RW (2006) The posterior longitudinal ligament and peridural (epidural) membrane. Clinical Anat 19:487–492CrossRef
12.
go back to reference Hashizume Y (1980) Pathological studies on the ossification of the posterior longitudinal ligament (OPLL). Acta Pathol Jpn 30:255–273PubMed Hashizume Y (1980) Pathological studies on the ossification of the posterior longitudinal ligament (OPLL). Acta Pathol Jpn 30:255–273PubMed
13.
go back to reference Mochizuki M, Aiba A, Hashimoto M, Fujiyoshi T, Yamazaki M (2009) Cervical myelopathy in patients with ossification of the posterior longitudinal ligament. J Neurosurg Spine 10:122–128PubMedCrossRef Mochizuki M, Aiba A, Hashimoto M, Fujiyoshi T, Yamazaki M (2009) Cervical myelopathy in patients with ossification of the posterior longitudinal ligament. J Neurosurg Spine 10:122–128PubMedCrossRef
14.
go back to reference Sato R, Uchida K, Kobayashi S, Yayama T, Kokubo Y, Nakajima H, Takamura T, Bangirana A, Itoh H, Baba H (2007) Ossification of the posterior longitudinal ligament of the cervical spine: histopathological findings around the calcification and ossification front. J Neurosurg Spine 7:174–183PubMedCrossRef Sato R, Uchida K, Kobayashi S, Yayama T, Kokubo Y, Nakajima H, Takamura T, Bangirana A, Itoh H, Baba H (2007) Ossification of the posterior longitudinal ligament of the cervical spine: histopathological findings around the calcification and ossification front. J Neurosurg Spine 7:174–183PubMedCrossRef
15.
go back to reference Yamamoto K, Kosaka T (2009) Updates of ossification of posterior longitudinal ligament. Effect of insulin/igf-1 signals and leptin signals on ossification of the spinal ligament in Zucker fatty rats. Clin Calcium 19:1462–1470 (in Japanese)PubMed Yamamoto K, Kosaka T (2009) Updates of ossification of posterior longitudinal ligament. Effect of insulin/igf-1 signals and leptin signals on ossification of the spinal ligament in Zucker fatty rats. Clin Calcium 19:1462–1470 (in Japanese)PubMed
16.
go back to reference Tanno T (1992) Experimental study on the spinal lesions in hyperostotic mouse (twy/twy): special reference to the pathogenesis of the ossification of the spinal ligaments and to the action of ethane-1-hydroxy-1, 1-diphosphonate (EHDP). Nippon Seikeigeka Gakkai Zasshi 66:1073–1083 (in Japanese)PubMed Tanno T (1992) Experimental study on the spinal lesions in hyperostotic mouse (twy/twy): special reference to the pathogenesis of the ossification of the spinal ligaments and to the action of ethane-1-hydroxy-1, 1-diphosphonate (EHDP). Nippon Seikeigeka Gakkai Zasshi 66:1073–1083 (in Japanese)PubMed
17.
go back to reference Takaishi H, Shiono Y, Matsumoto M (2009) Updates of ossification of posterior longitudinal ligament. Bone metabolism in ossifiction of posterior longitudinal ligament. Clin Calcium 19:1442–1447 (in Japanese)PubMed Takaishi H, Shiono Y, Matsumoto M (2009) Updates of ossification of posterior longitudinal ligament. Bone metabolism in ossifiction of posterior longitudinal ligament. Clin Calcium 19:1442–1447 (in Japanese)PubMed
18.
go back to reference Itoh H (1989) Histological study on the ossification of the yellow ligament in the thoracolumbar spines of the cadavers. Especially on the early stage of the ossification. Fukuoka Igaku Zasshi 80(12):527–535 (in Japanese)PubMed Itoh H (1989) Histological study on the ossification of the yellow ligament in the thoracolumbar spines of the cadavers. Especially on the early stage of the ossification. Fukuoka Igaku Zasshi 80(12):527–535 (in Japanese)PubMed
19.
go back to reference Gaucher AA, Péré PG, Gillet PM (1990) From ankylosing spondylitis to Forestier's disease: ossifying enthesopathy, a unifying concept. J Rheumatol 17:854–856PubMed Gaucher AA, Péré PG, Gillet PM (1990) From ankylosing spondylitis to Forestier's disease: ossifying enthesopathy, a unifying concept. J Rheumatol 17:854–856PubMed
20.
go back to reference Slobodin G, Rozenbaum M, Boulman N, Rosner I (2007) Varied presentations of enthesopathy. Semin Arthritis Rheum 37:119–126PubMedCrossRef Slobodin G, Rozenbaum M, Boulman N, Rosner I (2007) Varied presentations of enthesopathy. Semin Arthritis Rheum 37:119–126PubMedCrossRef
21.
go back to reference Rogers J, Shepstone L, Dieppe P (1997) Bone formers: osteophyte and enthesophyte formation are positively associated. Ann Rheum Dis 56:85–90PubMedCrossRef Rogers J, Shepstone L, Dieppe P (1997) Bone formers: osteophyte and enthesophyte formation are positively associated. Ann Rheum Dis 56:85–90PubMedCrossRef
22.
go back to reference Ball J (1983) The enthesopathy of ankylosing spondylitis. Br J Rheumatol 22:25–28PubMed Ball J (1983) The enthesopathy of ankylosing spondylitis. Br J Rheumatol 22:25–28PubMed
23.
go back to reference Hida K, Iwasaki Y, Koyanagi I, Abe H (1997) Bone window computed tomography for detection of dural defect associated with cervical ossified posterior longitudinal ligament. Neurol Med Chir 37:173–176CrossRef Hida K, Iwasaki Y, Koyanagi I, Abe H (1997) Bone window computed tomography for detection of dural defect associated with cervical ossified posterior longitudinal ligament. Neurol Med Chir 37:173–176CrossRef
24.
go back to reference Chang H, Kong CG, Won HY, Kim JH, Park JB (2010) Inter- and intra-observer variability of a cervical opll classification using reconstructed CT images. Clin Orthop Surg 2:8–12PubMedCrossRef Chang H, Kong CG, Won HY, Kim JH, Park JB (2010) Inter- and intra-observer variability of a cervical opll classification using reconstructed CT images. Clin Orthop Surg 2:8–12PubMedCrossRef
Metadata
Title
Is ossification of posterior longitudinal ligament an enthesopathy?
Authors
Jian Chen
Dianwen Song
Xinwei Wang
Xiaolong Shen
Yang Li
Wen Yuan
Publication date
01-10-2011
Publisher
Springer-Verlag
Published in
International Orthopaedics / Issue 10/2011
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-010-1163-9

Other articles of this Issue 10/2011

International Orthopaedics 10/2011 Go to the issue