Skip to main content
Top
Published in: International Orthopaedics 6/2007

01-12-2007 | Review

Newly reported roles of thyroid-stimulating hormone and follicle-stimulating hormone in bone remodelling

Authors: Rebecca A. Sendak, T. Kuber Sampath, John M. McPherson

Published in: International Orthopaedics | Issue 6/2007

Login to get access

Abstract

Thyroid-stimulating hormone (TSH) and follicle-stimulating hormone (FSH) have both been recently implicated in bone remodelling. Clinical evidence, as well as data from TSH receptor and thyroid hormone receptor knockout mice, suggest that TSH has a direct effect on skeletal homeostasis, although some data are conflicting. Recently, the exogenous administration of TSH has been shown to positively impact bone in oophrectomised rats. These data, along with their potential implications for the treatment of severe osteoporosis, are discussed.
Literature
1.
go back to reference Abe E, Marians RC, Yu W, Wu X-B, Ando T, Li Y, Iqbal J, Eldeiry L, Rajendren G, Blair HC, Davies TF, Zaidi M (2003) TSH is a negative regulator of skeletal remodeling. Cell 115:151–162PubMedCrossRef Abe E, Marians RC, Yu W, Wu X-B, Ando T, Li Y, Iqbal J, Eldeiry L, Rajendren G, Blair HC, Davies TF, Zaidi M (2003) TSH is a negative regulator of skeletal remodeling. Cell 115:151–162PubMedCrossRef
2.
go back to reference Bassett JHD, O’Shea PJ, Sriskantharajah S, Rabier B, Boyde A, Howell PGT, Weiss RE, Roux J-P, Malaval L, Clement-Lacroix P, Samarut J, Chassande O, Williams GR (2007) Thyroid hormone excess rather than thyrotropin deficiency induces osteoporosis in hyperthyroidism. Mol Endocrinol 21:1095–1107PubMedCrossRef Bassett JHD, O’Shea PJ, Sriskantharajah S, Rabier B, Boyde A, Howell PGT, Weiss RE, Roux J-P, Malaval L, Clement-Lacroix P, Samarut J, Chassande O, Williams GR (2007) Thyroid hormone excess rather than thyrotropin deficiency induces osteoporosis in hyperthyroidism. Mol Endocrinol 21:1095–1107PubMedCrossRef
3.
go back to reference Dierich A, Sairam MR, Monaco L, Fimia GM, Gansmuller A, LeMeur M, Sassone-Corsi P (1998) Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Cell Biol 95:13612–13617 Dierich A, Sairam MR, Monaco L, Fimia GM, Gansmuller A, LeMeur M, Sassone-Corsi P (1998) Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Cell Biol 95:13612–13617
4.
go back to reference Greenspan SL, Greenspan FS (1999) The effect of thyroid hormone on skeletal integrity. Ann Intern Med 130:750–758PubMed Greenspan SL, Greenspan FS (1999) The effect of thyroid hormone on skeletal integrity. Ann Intern Med 130:750–758PubMed
5.
go back to reference Grossman M, Weintraub BD, Szkudlinski MW (1997) Novel insights into the molecular mechanisms of human thyrotropin action: structural, physiological, and therapeutic implications for the glycoprotein hormone family. Endocr Rev 18:476–501CrossRef Grossman M, Weintraub BD, Szkudlinski MW (1997) Novel insights into the molecular mechanisms of human thyrotropin action: structural, physiological, and therapeutic implications for the glycoprotein hormone family. Endocr Rev 18:476–501CrossRef
6.
go back to reference Hase H, Ando T, Eldeiry L, Brebene A, Peng Y, Lin L, Amano H, Davies TF, Sun L, Zaidi M, Abe E (2006) TNFα mediates the skeletal effects of thyroid-stimulating hormone. Proc Natl Acad Sci USA 103:12849–12854PubMedCrossRef Hase H, Ando T, Eldeiry L, Brebene A, Peng Y, Lin L, Amano H, Davies TF, Sun L, Zaidi M, Abe E (2006) TNFα mediates the skeletal effects of thyroid-stimulating hormone. Proc Natl Acad Sci USA 103:12849–12854PubMedCrossRef
7.
go back to reference Ibqal J, Sun L, Kumar TR, Blair HC, Zaidi M (2006) Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation. Proc Natl Acad Sci USA 103:14925–14930CrossRef Ibqal J, Sun L, Kumar TR, Blair HC, Zaidi M (2006) Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation. Proc Natl Acad Sci USA 103:14925–14930CrossRef
8.
go back to reference Kim DJ, Khang YH, Koh J-M, Shong YK, Kim GS (2006) Low normal TSH levels are associated with low bone mineral density in healthy postmenopausal women. Clin Endocrinol 64:86–90CrossRef Kim DJ, Khang YH, Koh J-M, Shong YK, Kim GS (2006) Low normal TSH levels are associated with low bone mineral density in healthy postmenopausal women. Clin Endocrinol 64:86–90CrossRef
9.
go back to reference Martini G, Pacini F, Campagna, MS, Fanci B, Azvanzati A, Lucani B, Salvadori S, Gennari L, Valenti R, DePaola V, Pilli T, Nuti R (2005) The effects of recombinant TSH on bone turnover markers and serum osteoprotegerin and RANKL levels. In: Presentation SU378 of the American Society for Bone and Mineral Research (ASBMR) 27th Annual Meeting, Nashville, Tennessee, September 2005 Martini G, Pacini F, Campagna, MS, Fanci B, Azvanzati A, Lucani B, Salvadori S, Gennari L, Valenti R, DePaola V, Pilli T, Nuti R (2005) The effects of recombinant TSH on bone turnover markers and serum osteoprotegerin and RANKL levels. In: Presentation SU378 of the American Society for Bone and Mineral Research (ASBMR) 27th Annual Meeting, Nashville, Tennessee, September 2005
10.
go back to reference Mazziotti G, Sorvillo F, Piscopo M, Cioffi M, Pillo P, Biondi B, Iorio S, Giustina A, Amato G, Carelly C (2005) Recombinant human TSH modulates in vivo C-telopeptides of type-1 collagen and bone alkaline phosphatase, but not osteoprotegerin production in postmenopausal women monitored for differentiated thyroid carcinoma. J Bone Miner Res 20:480–486PubMedCrossRef Mazziotti G, Sorvillo F, Piscopo M, Cioffi M, Pillo P, Biondi B, Iorio S, Giustina A, Amato G, Carelly C (2005) Recombinant human TSH modulates in vivo C-telopeptides of type-1 collagen and bone alkaline phosphatase, but not osteoprotegerin production in postmenopausal women monitored for differentiated thyroid carcinoma. J Bone Miner Res 20:480–486PubMedCrossRef
11.
go back to reference Morris MS (2007) The association between serum thyroid-stimulating hormone in its reference range and bone status in postmenopausal American women. Bone 40:1128–1134PubMedCrossRef Morris MS (2007) The association between serum thyroid-stimulating hormone in its reference range and bone status in postmenopausal American women. Bone 40:1128–1134PubMedCrossRef
12.
go back to reference Onigata K, Kowasi T, Nishiyama S, Micuno H, Morikawa A (2005) Bone mineral density in human cases with TSH receptor gene mutations. In: Proceedings of the New York Academy of Sciences 1st Conference on Skeletal Development and Remodeling in Health, Disease, and Aging, New York, May 2005, vol 1, p 11 Onigata K, Kowasi T, Nishiyama S, Micuno H, Morikawa A (2005) Bone mineral density in human cases with TSH receptor gene mutations. In: Proceedings of the New York Academy of Sciences 1st Conference on Skeletal Development and Remodeling in Health, Disease, and Aging, New York, May 2005, vol 1, p 11
13.
go back to reference Pantazi H, Papapetrou PD (2000) Changes in parameters of bone and mineral metabolism during therapy for hyperthyroidism. J Clin Endocrinol Metab 85:1099–1106PubMedCrossRef Pantazi H, Papapetrou PD (2000) Changes in parameters of bone and mineral metabolism during therapy for hyperthyroidism. J Clin Endocrinol Metab 85:1099–1106PubMedCrossRef
14.
go back to reference Ramirez L, Braverman LE, White B, Emerson CH (1997) Recombinant human thyrotropin is a potent stimulator of thyroid function in normal subjects. J Clin Endocrinol Metab 82:2836–2839PubMedCrossRef Ramirez L, Braverman LE, White B, Emerson CH (1997) Recombinant human thyrotropin is a potent stimulator of thyroid function in normal subjects. J Clin Endocrinol Metab 82:2836–2839PubMedCrossRef
15.
go back to reference Sampath TK, Simic P, Sendak R, Draca N, Bowe AE, O’Brien S, Schiavi SC, McPherson JM, Vukicevic S (2007) Thyroid-stimulating hormone restores bone volume, microarchitecture, and strength in aged ovariectomized rats. J Bone Miner Res 22:849–859PubMedCrossRef Sampath TK, Simic P, Sendak R, Draca N, Bowe AE, O’Brien S, Schiavi SC, McPherson JM, Vukicevic S (2007) Thyroid-stimulating hormone restores bone volume, microarchitecture, and strength in aged ovariectomized rats. J Bone Miner Res 22:849–859PubMedCrossRef
16.
go back to reference Sun L, Davies TF, Blair HC, Abe E, Zaidi M (2006) TSH and bone loss. Ann NY Acad Sci 1068:309–318PubMedCrossRef Sun L, Davies TF, Blair HC, Abe E, Zaidi M (2006) TSH and bone loss. Ann NY Acad Sci 1068:309–318PubMedCrossRef
17.
go back to reference Sun L, Zhang Z, Iqbal J, Zaidi S, Papachristou DJ, Zhou H, Sharrow AC, Peng Y, Yaroslavskiy BB, Zhu L-L, Zallone A, Sairam MR, Kumkar TR, Landa LC, Schaffler MB, Moonga BS, Blaire HC, Zaidi M (2006) FSH directly regulates bone mass. Cell 125:247–260PubMedCrossRef Sun L, Zhang Z, Iqbal J, Zaidi S, Papachristou DJ, Zhou H, Sharrow AC, Peng Y, Yaroslavskiy BB, Zhu L-L, Zallone A, Sairam MR, Kumkar TR, Landa LC, Schaffler MB, Moonga BS, Blaire HC, Zaidi M (2006) FSH directly regulates bone mass. Cell 125:247–260PubMedCrossRef
18.
go back to reference Szkudlinski MW, Grossmann M, Leitolf H, Weintraub BD (2000) Human thyroid-stimulating hormone: structure–function analysis. Methods 21:67–81PubMedCrossRef Szkudlinski MW, Grossmann M, Leitolf H, Weintraub BD (2000) Human thyroid-stimulating hormone: structure–function analysis. Methods 21:67–81PubMedCrossRef
Metadata
Title
Newly reported roles of thyroid-stimulating hormone and follicle-stimulating hormone in bone remodelling
Authors
Rebecca A. Sendak
T. Kuber Sampath
John M. McPherson
Publication date
01-12-2007
Publisher
Springer-Verlag
Published in
International Orthopaedics / Issue 6/2007
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-007-0417-7

Other articles of this Issue 6/2007

International Orthopaedics 6/2007 Go to the issue