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01-09-2012 | Symposium-in-writing paper

Epidemiology: allergy history, IgE, and cancer

Author: Michelle C. Turner

Published in: Cancer Immunology, Immunotherapy | Issue 9/2012

Abstract

Numerous epidemiological studies have investigated potential associations between allergy history and cancer risk with strong inverse associations reported in studies of pancreatic cancer, glioma, and childhood leukemia. Recently, there has been a rapid expansion of the epidemiological literature both of studies evaluating self-reported allergy history in relation to cancer risk and of studies evaluating biological indicators of allergy history and immune function including levels of immunoglobulin (Ig) E. However, there are several potential methodological limitations associated with prior studies, and further research is required to clarify associations observed. This paper summarizes the recent epidemiological literature examining associations between allergy history and cancer risk. From 2008, a total of 55 epidemiological studies were identified that examined some aspect of the association between allergy and cancer. Although the majority of studies examined self-reported allergy history in relation to cancer risk, there were also studies examining allergy diagnoses or discharges as captured in existing administrative databases, levels of IgE, polymorphisms of allergy, inflammatory- or allergy-related cytokine genes, and concentrations of immune regulatory proteins. The most frequently studied cancer sites included brain and lymphatic and hematopoietic cancers. Potential methodological sources of bias are discussed as well as recommendations for future work.

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Title: Epidemiology: allergy history, IgE, and cancer
Author: Michelle C. Turner
Publication date: 01-09-2012
Publisher: Springer-Verlag
Published in: Cancer Immunology, Immunotherapy / Issue 9/2012
Print ISSN: 0340-7004
Electronic ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-011-1180-6

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Springer Medicine

Abstract

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Other articles of this Issue 9/2012

How to connect an IgE-driven response with CTL activity?

Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application

Expression of IL-15 in NK cells results in rapid enrichment and selective cytotoxicity of gene-modified effectors that carry a tumor-specific antigen receptor

Quality of life during dendritic cell vaccination against metastatic renal cell carcinoma

IL-15 augments antitumoral activity of an ErbB2/HER2 cancer vaccine targeted to professional antigen-presenting cells

Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes

Keynote webinar | Spotlight on antibody–drug conjugates in cancer