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European Journal of Nuclear Medicine and Molecular Imaging

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01-02-2019 | Original Article

Differences in gray and white matter ¹⁸F-THK5351 uptake between behavioral-variant frontotemporal dementia and other dementias

Authors: Hye Joo Son, Jungsu S. Oh, Jee Hoon Roh, Sang Won Seo, Minyoung Oh, Sang Ju Lee, Seung Jun Oh, Jae Seung Kim

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 2/2019

Abstract

Purpose

We investigated the regional distribution of ¹⁸F-THK5351 uptake in gray (GM) and white matter (WM) in patients with behavioral-variant frontotemporal dementia (bvFTD) and compared it with that in patients with Alzheimer’s disease (AD) or semantic dementia (SD).

Methods

¹⁸F-THK-5351 positron emission tomography (PET), ¹⁸F-florbetaben PET, magnetic resonance imaging, and neuropsychological testing were performed in 103 subjects including 30, 24, 9, and 8 patients with mild cognitive impairment, AD, bvFTD, and SD, respectively, and 32 normal subjects. Standardized uptake value ratios (SUVRs) of ¹⁸F-THK-5351 PET images were measured from six GM and WM regions using cerebellar GM as reference. GM and WM SUVRs and WM/GM ratios, the relationship between GM SUVR and WM/GM ratio, and correlation between SUVR and cognitive function were compared.

Results

In AD, both parietal GM (p < 0.001) and WM (p < 0.001) SUVRs were higher than in bvFTD. In AD and SD, the WM/GM ratio decreased as the GM SUVR increased, regardless of lobar region. In AD, memory function correlated with parietal GM (ρ = −0.74, p < 0.001) and WM (ρ = −0.53, p < 0.001) SUVR. In SD, language function correlated with temporal GM SUVR (ρ = −0.69, p = 0.006). The frontal WM SUVR was higher in bvFTD than in AD (p = 0.003) or SD (p = 0.017). The frontal WM/GM ratio was higher in bvFTD than in AD (p < 0.001). In bvFTD, the WM/GM ratio increased more prominently than the GM SUVR only in the frontal lobe (R² = 0.026). In bvFTD, executive function correlated with frontal WM SUVR (ρ = −0.64, p = 0.014).

Conclusions

Frontal WM ¹⁸F-THK5351 uptake was higher in bvFTD than in other dementias. The increase in frontal WM uptake was greater than the increase in GM uptake and correlated with executive function. This suggests that frontal lobe WM ¹⁸F-THK5351 uptake reflects neuropathological differences between bvFTD and other dementias.

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Title: Differences in gray and white matter 18F-THK5351 uptake between behavioral-variant frontotemporal dementia and other dementias
Authors: Hye Joo Son
Jungsu S. Oh
Jee Hoon Roh
Sang Won Seo
Minyoung Oh
Sang Ju Lee
Seung Jun Oh
Jae Seung Kim
Publication date: 01-02-2019
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 2/2019
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-018-4125-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Differences in gray and white matter ¹⁸F-THK5351 uptake between behavioral-variant frontotemporal dementia and other dementias

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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