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Published in: European Journal of Nuclear Medicine and Molecular Imaging 9/2016

Open Access 01-08-2016 | Guidelines

The EANM practice guidelines for bone scintigraphy

Authors: T. Van den Wyngaert, K. Strobel, W. U. Kampen, T. Kuwert, W. van der Bruggen, H. K. Mohan, G. Gnanasegaran, R. Delgado-Bolton, W. A. Weber, M. Beheshti, W. Langsteger, F. Giammarile, F. M. Mottaghy, F. Paycha, On behalf of the EANM Bone & Joint Committee and the Oncology Committee.

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2016

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Abstract

Purpose

The radionuclide bone scan is the cornerstone of skeletal nuclear medicine imaging. Bone scintigraphy is a highly sensitive diagnostic nuclear medicine imaging technique that uses a radiotracer to evaluate the distribution of active bone formation in the skeleton related to malignant and benign disease, as well as physiological processes.

Methods

The European Association of Nuclear Medicine (EANM) has written and approved these guidelines to promote the use of nuclear medicine procedures of high quality.

Conclusion

The present guidelines offer assistance to nuclear medicine practitioners in optimizing the diagnostic procedure and interpreting bone scintigraphy. These guidelines describe the protocols that are currently accepted and used routinely, but do not include all existing procedures. They should therefore not be taken as exclusive of other nuclear medicine modalities that can be used to obtain comparable results. It is important to remember that the resources and facilities available for patient care may vary.
Literature
1.
go back to reference Kosuda S, Kaji T, Yokoyama H, Yokokawa T, Katayama M, Iriye T, et al. Does bone SPECT actually have lower sensitivity for detecting vertebral metastasis than MRI? J Nucl Med. 1996;37:975–8.PubMed Kosuda S, Kaji T, Yokoyama H, Yokokawa T, Katayama M, Iriye T, et al. Does bone SPECT actually have lower sensitivity for detecting vertebral metastasis than MRI? J Nucl Med. 1996;37:975–8.PubMed
2.
go back to reference Horger M, Eschmann SM, Pfannenberg C, Vonthein R, Besenfelder H, Claussen CD, et al. Evaluation of combined transmission and emission tomography for classification of skeletal lesions. AJR Am J Roentgenol. 2004;183:655–61.CrossRefPubMed Horger M, Eschmann SM, Pfannenberg C, Vonthein R, Besenfelder H, Claussen CD, et al. Evaluation of combined transmission and emission tomography for classification of skeletal lesions. AJR Am J Roentgenol. 2004;183:655–61.CrossRefPubMed
3.
go back to reference Bombardieri E, Aktolun C, Baum RP, Bishof-Delaloye A, Buscombe J, Chatal JF, et al. Bone scintigraphy: procedure guidelines for tumour imaging. Eur J Nucl Med Mol Imaging. 2003;30:BP99–BP106.PubMed Bombardieri E, Aktolun C, Baum RP, Bishof-Delaloye A, Buscombe J, Chatal JF, et al. Bone scintigraphy: procedure guidelines for tumour imaging. Eur J Nucl Med Mol Imaging. 2003;30:BP99–BP106.PubMed
5.
go back to reference Commissie Kwaliteitsbevordering Nederlandse Vereniging Nucleaire Geneeskunde. Skeletscintigrafie. In: Barneveld P, van Urk P, editors. Aanbevelingen Nucleaire Geneeskunde. Neer: Kloosterhof acquisitie services – uitgeverij; 2007. p. 155–60. Commissie Kwaliteitsbevordering Nederlandse Vereniging Nucleaire Geneeskunde. Skeletscintigrafie. In: Barneveld P, van Urk P, editors. Aanbevelingen Nucleaire Geneeskunde. Neer: Kloosterhof acquisitie services – uitgeverij; 2007. p. 155–60.
6.
go back to reference Société Française de Médecine Nucléaire et Imagerie Moléculaire (SFMN). Guidelines for writing protocols for bone scintigraphy. Med Nucl. 2012;687–97. Société Française de Médecine Nucléaire et Imagerie Moléculaire (SFMN). Guidelines for writing protocols for bone scintigraphy. Med Nucl. 2012;687–97.
7.
go back to reference Beheshti M, Mottaghy FM, Paycha F, Behrendt FF, Van den Wyngaert T, Fogelman I, et al. (18)F-NaF PET/CT: EANM procedure guidelines for bone imaging. Eur J Nucl Med Mol Imaging. 2015;42:1767–77.CrossRefPubMed Beheshti M, Mottaghy FM, Paycha F, Behrendt FF, Van den Wyngaert T, Fogelman I, et al. (18)F-NaF PET/CT: EANM procedure guidelines for bone imaging. Eur J Nucl Med Mol Imaging. 2015;42:1767–77.CrossRefPubMed
8.
go back to reference Segall G, Delbeke D, Stabin MG, Even-Sapir E, Fair J, Sajdak R, et al. SNM practice guideline for sodium 18F-fluoride PET/CT bone scans 1.0. J Nucl Med. 2010;51:1813–20.CrossRefPubMed Segall G, Delbeke D, Stabin MG, Even-Sapir E, Fair J, Sajdak R, et al. SNM practice guideline for sodium 18F-fluoride PET/CT bone scans 1.0. J Nucl Med. 2010;51:1813–20.CrossRefPubMed
9.
go back to reference Stauss J, Hahn K, Mann M, De Palma D. Guidelines for paediatric bone scanning with 99mTc-labelled radiopharmaceuticals and 18F-fluoride. Eur J Nucl Med Mol Imaging. 2010;37:1621–8.CrossRefPubMed Stauss J, Hahn K, Mann M, De Palma D. Guidelines for paediatric bone scanning with 99mTc-labelled radiopharmaceuticals and 18F-fluoride. Eur J Nucl Med Mol Imaging. 2010;37:1621–8.CrossRefPubMed
10.
go back to reference Fogelman I, Gnanasegaran G, Van der Wall H. Radionuclide and hybrid bone imaging. Berlin: Springer; 2013. Fogelman I, Gnanasegaran G, Van der Wall H. Radionuclide and hybrid bone imaging. Berlin: Springer; 2013.
11.
go back to reference Yang DC, Ratani RS, Mittal PK, Chua RS, Pate SM. Radionuclide three-phase whole-body bone imaging. Clin Nucl Med. 2002;27:419–26.CrossRefPubMed Yang DC, Ratani RS, Mittal PK, Chua RS, Pate SM. Radionuclide three-phase whole-body bone imaging. Clin Nucl Med. 2002;27:419–26.CrossRefPubMed
12.
go back to reference Bares R. Skeletal scintigraphy in breast cancer management. Q J Nucl Med. 1998;42:43–8.PubMed Bares R. Skeletal scintigraphy in breast cancer management. Q J Nucl Med. 1998;42:43–8.PubMed
13.
go back to reference Cook GJ, Fogelman I. Skeletal metastases from breast cancer: imaging with nuclear medicine. Semin Nucl Med. 1999;29:69–79.CrossRefPubMed Cook GJ, Fogelman I. Skeletal metastases from breast cancer: imaging with nuclear medicine. Semin Nucl Med. 1999;29:69–79.CrossRefPubMed
14.
go back to reference Cook GJ, Fogelman I. The role of nuclear medicine in monitoring treatment in skeletal malignancy. Semin Nucl Med. 2001;31:206–11.CrossRefPubMed Cook GJ, Fogelman I. The role of nuclear medicine in monitoring treatment in skeletal malignancy. Semin Nucl Med. 2001;31:206–11.CrossRefPubMed
15.
go back to reference Dose J, Bleckmann C, Bachmann S, Bohuslavizki KH, Berger J, Jenicke L, et al. Comparison of fluorodeoxyglucose positron emission tomography and “conventional diagnostic procedures” for the detection of distant metastases in breast cancer patients. Nucl Med Commun. 2002;23:857–64.CrossRefPubMed Dose J, Bleckmann C, Bachmann S, Bohuslavizki KH, Berger J, Jenicke L, et al. Comparison of fluorodeoxyglucose positron emission tomography and “conventional diagnostic procedures” for the detection of distant metastases in breast cancer patients. Nucl Med Commun. 2002;23:857–64.CrossRefPubMed
16.
go back to reference Gallowitsch HJ, Kresnik E, Gasser J, Kumnig G, Igerc I, Mikosch P, et al. F-18 fluorodeoxyglucose positron-emission tomography in the diagnosis of tumor recurrence and metastases in the follow-up of patients with breast carcinoma: a comparison to conventional imaging. Invest Radiol. 2003;38:250–6.PubMed Gallowitsch HJ, Kresnik E, Gasser J, Kumnig G, Igerc I, Mikosch P, et al. F-18 fluorodeoxyglucose positron-emission tomography in the diagnosis of tumor recurrence and metastases in the follow-up of patients with breast carcinoma: a comparison to conventional imaging. Invest Radiol. 2003;38:250–6.PubMed
17.
go back to reference Even-Sapir E. Imaging of malignant bone involvement by morphologic, scintigraphic, and hybrid modalities. J Nucl Med. 2005;46:1356–67.PubMed Even-Sapir E. Imaging of malignant bone involvement by morphologic, scintigraphic, and hybrid modalities. J Nucl Med. 2005;46:1356–67.PubMed
18.
go back to reference Orzel JA, Sawaf NW, Richardson ML. Lymphoma of the skeleton: scintigraphic evaluation. AJR Am J Roentgenol. 1988;150:1095–9.CrossRefPubMed Orzel JA, Sawaf NW, Richardson ML. Lymphoma of the skeleton: scintigraphic evaluation. AJR Am J Roentgenol. 1988;150:1095–9.CrossRefPubMed
19.
go back to reference Franzius C, Sciuk J, Daldrup-Link HE, Jurgens H, Schober O. FDG-PET for detection of osseous metastases from malignant primary bone tumours: comparison with bone scintigraphy. Eur J Nucl Med. 2000;27:1305–11.CrossRefPubMed Franzius C, Sciuk J, Daldrup-Link HE, Jurgens H, Schober O. FDG-PET for detection of osseous metastases from malignant primary bone tumours: comparison with bone scintigraphy. Eur J Nucl Med. 2000;27:1305–11.CrossRefPubMed
20.
go back to reference Cook GJ, Houston S, Rubens R, Maisey MN, Fogelman I. Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions. J Clin Oncol. 1998;16:3375–9.PubMed Cook GJ, Houston S, Rubens R, Maisey MN, Fogelman I. Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions. J Clin Oncol. 1998;16:3375–9.PubMed
21.
go back to reference Ohta M, Tokuda Y, Suzuki Y, Kubota M, Makuuchi H, Tajima T, et al. Whole body PET for the evaluation of bony metastases in patients with breast cancer: comparison with 99Tcm-MDP bone scintigraphy. Nucl Med Commun. 2001;22:875–9.CrossRefPubMed Ohta M, Tokuda Y, Suzuki Y, Kubota M, Makuuchi H, Tajima T, et al. Whole body PET for the evaluation of bony metastases in patients with breast cancer: comparison with 99Tcm-MDP bone scintigraphy. Nucl Med Commun. 2001;22:875–9.CrossRefPubMed
22.
go back to reference Hetzel M, Arslandemir C, Konig HH, Buck AK, Nussle K, Glatting G. F-18 NaF PET for detection of bone metastases in lung cancer: accuracy, cost-effectiveness, and impact on patient management. J Bone Miner Res. 2003;18:2206–14.CrossRefPubMed Hetzel M, Arslandemir C, Konig HH, Buck AK, Nussle K, Glatting G. F-18 NaF PET for detection of bone metastases in lung cancer: accuracy, cost-effectiveness, and impact on patient management. J Bone Miner Res. 2003;18:2206–14.CrossRefPubMed
23.
go back to reference Nakamoto Y, Osman M, Wahl RL. Prevalence and patterns of bone metastases detected with positron emission tomography using F-18 FDG. Clin Nucl Med. 2003;28:302–7.PubMed Nakamoto Y, Osman M, Wahl RL. Prevalence and patterns of bone metastases detected with positron emission tomography using F-18 FDG. Clin Nucl Med. 2003;28:302–7.PubMed
24.
go back to reference Uematsu T, Yuen S, Yukisawa S, Aramaki T, Morimoto N, Endo M, et al. Comparison of FDG PET and SPECT for detection of bone metastases in breast cancer. AJR Am J Roentgenol. 2005;184:1266–73.CrossRefPubMed Uematsu T, Yuen S, Yukisawa S, Aramaki T, Morimoto N, Endo M, et al. Comparison of FDG PET and SPECT for detection of bone metastases in breast cancer. AJR Am J Roentgenol. 2005;184:1266–73.CrossRefPubMed
25.
go back to reference Scher HI, Halabi S, Tannock I, Morris M, Sternberg CN, Carducci MA, et al. Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group. J Clin Oncol. 2008;26:1148–59.CrossRefPubMedPubMedCentral Scher HI, Halabi S, Tannock I, Morris M, Sternberg CN, Carducci MA, et al. Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group. J Clin Oncol. 2008;26:1148–59.CrossRefPubMedPubMedCentral
26.
go back to reference Dennis ER, Jia X, Mezheritskiy IS, Stephenson RD, Schoder H, Fox JJ, et al. Bone scan index: a quantitative treatment response biomarker for castration-resistant metastatic prostate cancer. J Clin Oncol. 2012;30:519–24.CrossRefPubMedPubMedCentral Dennis ER, Jia X, Mezheritskiy IS, Stephenson RD, Schoder H, Fox JJ, et al. Bone scan index: a quantitative treatment response biomarker for castration-resistant metastatic prostate cancer. J Clin Oncol. 2012;30:519–24.CrossRefPubMedPubMedCentral
27.
go back to reference Duer A, Ostergaard M, Horslev-Petersen K, Vallo J. Magnetic resonance imaging and bone scintigraphy in the differential diagnosis of unclassified arthritis. Ann Rheum Dis. 2008;67:48–51.CrossRefPubMed Duer A, Ostergaard M, Horslev-Petersen K, Vallo J. Magnetic resonance imaging and bone scintigraphy in the differential diagnosis of unclassified arthritis. Ann Rheum Dis. 2008;67:48–51.CrossRefPubMed
28.
go back to reference Ryan PJ, Gibson T, Fogelman I. Spinal bone SPECT in chronic symptomatic ankylosing spondylitis. Clin Nucl Med. 1997;22:821–4.CrossRefPubMed Ryan PJ, Gibson T, Fogelman I. Spinal bone SPECT in chronic symptomatic ankylosing spondylitis. Clin Nucl Med. 1997;22:821–4.CrossRefPubMed
29.
go back to reference Guglielmi G, Cascavilla A, Scalzo G, Salaffi F, Grassi W. Imaging of sternocostoclavicular joint in spondyloarthropathies and other rheumatic conditions. Clin Exp Rheumatol. 2009;27:402–8.PubMed Guglielmi G, Cascavilla A, Scalzo G, Salaffi F, Grassi W. Imaging of sternocostoclavicular joint in spondyloarthropathies and other rheumatic conditions. Clin Exp Rheumatol. 2009;27:402–8.PubMed
30.
go back to reference Makki D, Khazim R, Zaidan AA, Ravi K, Toma T. Single photon emission computerized tomography (SPECT) scan-positive facet joints and other spinal structures in a hospital-wide population with spinal pain. Spine J. 2010;10:58–62.CrossRefPubMed Makki D, Khazim R, Zaidan AA, Ravi K, Toma T. Single photon emission computerized tomography (SPECT) scan-positive facet joints and other spinal structures in a hospital-wide population with spinal pain. Spine J. 2010;10:58–62.CrossRefPubMed
31.
go back to reference Dieppe P, Cushnaghan J, Young P, Kirwan J. Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy. Ann Rheum Dis. 1993;52:557–63.CrossRefPubMedPubMedCentral Dieppe P, Cushnaghan J, Young P, Kirwan J. Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy. Ann Rheum Dis. 1993;52:557–63.CrossRefPubMedPubMedCentral
32.
go back to reference Van den Wyngaert T, Huizing MT, Fossion E, Vermorken JB. Prognostic value of bone scintigraphy in cancer patients with osteonecrosis of the jaw. Clin Nucl Med. 2011;36:17–20.CrossRefPubMed Van den Wyngaert T, Huizing MT, Fossion E, Vermorken JB. Prognostic value of bone scintigraphy in cancer patients with osteonecrosis of the jaw. Clin Nucl Med. 2011;36:17–20.CrossRefPubMed
33.
go back to reference Brown ML, Collier Jr BD, Fogelman I. Bone scintigraphy: Part 1. Oncology and infection. J Nucl Med. 1993;34:2236–40.PubMed Brown ML, Collier Jr BD, Fogelman I. Bone scintigraphy: Part 1. Oncology and infection. J Nucl Med. 1993;34:2236–40.PubMed
34.
go back to reference Jamar F, Buscombe J, Chiti A, Christian PE, Delbeke D, Donohoe KJ, et al. EANM/SNMMI guideline for 18F-FDG use in inflammation and infection. J Nucl Med. 2013;54:647–58.CrossRefPubMed Jamar F, Buscombe J, Chiti A, Christian PE, Delbeke D, Donohoe KJ, et al. EANM/SNMMI guideline for 18F-FDG use in inflammation and infection. J Nucl Med. 2013;54:647–58.CrossRefPubMed
35.
go back to reference Jutte P, Lazzeri E, Sconfienza LM, Cassar-Pullicino V, Trampuz A, Petrosillo N, et al. Diagnostic flowcharts in osteomyelitis, spondylodiscitis and prosthetic joint infection. Q J Nucl Med Mol Imaging. 2014;58:2–19.PubMed Jutte P, Lazzeri E, Sconfienza LM, Cassar-Pullicino V, Trampuz A, Petrosillo N, et al. Diagnostic flowcharts in osteomyelitis, spondylodiscitis and prosthetic joint infection. Q J Nucl Med Mol Imaging. 2014;58:2–19.PubMed
36.
go back to reference Collier Jr BD, Fogelman I, Brown ML. Bone scintigraphy: Part 2. Orthopedic bone scanning. J Nucl Med. 1993;34:2241–6.PubMed Collier Jr BD, Fogelman I, Brown ML. Bone scintigraphy: Part 2. Orthopedic bone scanning. J Nucl Med. 1993;34:2241–6.PubMed
37.
go back to reference Holder LE. Bone scintigraphy in skeletal trauma. Radiol Clin North Am. 1993;31:739–81.PubMed Holder LE. Bone scintigraphy in skeletal trauma. Radiol Clin North Am. 1993;31:739–81.PubMed
38.
go back to reference Di Leo C, Tarolo GL, Aliberti G, Ardemagni A, Conte A, Bestetti A, et al. Stress fracture and coexistent periosteal reaction (“shin splints”) in a young athlete revealed by bone scintigraphy. Nuklearmedizin. 2000;39:N50–1.PubMed Di Leo C, Tarolo GL, Aliberti G, Ardemagni A, Conte A, Bestetti A, et al. Stress fracture and coexistent periosteal reaction (“shin splints”) in a young athlete revealed by bone scintigraphy. Nuklearmedizin. 2000;39:N50–1.PubMed
39.
go back to reference Huellner MW, Burkert A, Strobel K, Perez Lago Mdel S, Werner L, Hug U, et al. Imaging non-specific wrist pain: interobserver agreement and diagnostic accuracy of SPECT/CT, MRI, CT, bone scan and plain radiographs. PLoS One. 2013;8:e85359.CrossRefPubMedPubMedCentral Huellner MW, Burkert A, Strobel K, Perez Lago Mdel S, Werner L, Hug U, et al. Imaging non-specific wrist pain: interobserver agreement and diagnostic accuracy of SPECT/CT, MRI, CT, bone scan and plain radiographs. PLoS One. 2013;8:e85359.CrossRefPubMedPubMedCentral
40.
go back to reference Fogelman I, Collier BD, Brown ML. Bone scintigraphy: Part 3. Bone scanning in metabolic bone disease. J Nucl Med. 1993;34:2247–52.PubMed Fogelman I, Collier BD, Brown ML. Bone scintigraphy: Part 3. Bone scanning in metabolic bone disease. J Nucl Med. 1993;34:2247–52.PubMed
41.
go back to reference Mari C, Catafau A, Carrio I. Bone scintigraphy and metabolic disorders. Q J Nucl Med. 1999;43:259–67.PubMed Mari C, Catafau A, Carrio I. Bone scintigraphy and metabolic disorders. Q J Nucl Med. 1999;43:259–67.PubMed
42.
go back to reference Hain SF, Fogelman I. Nuclear medicine studies in metabolic bone disease. Semin Musculoskelet Radiol. 2002;6:323–9.CrossRefPubMed Hain SF, Fogelman I. Nuclear medicine studies in metabolic bone disease. Semin Musculoskelet Radiol. 2002;6:323–9.CrossRefPubMed
43.
44.
go back to reference de Graaf P, Schicht IM, Pauwels EK, te Velde J, de Graeff J. Bone scintigraphy in renal osteodystrophy. J Nucl Med. 1978;19:1289–96.PubMed de Graaf P, Schicht IM, Pauwels EK, te Velde J, de Graeff J. Bone scintigraphy in renal osteodystrophy. J Nucl Med. 1978;19:1289–96.PubMed
45.
go back to reference de Jonge FA, Pauwels EK, Hamdy NA. Scintigraphy in the clinical evaluation of disorders of mineral and skeletal metabolism in renal failure. Eur J Nucl Med. 1991;18:839–55.CrossRefPubMed de Jonge FA, Pauwels EK, Hamdy NA. Scintigraphy in the clinical evaluation of disorders of mineral and skeletal metabolism in renal failure. Eur J Nucl Med. 1991;18:839–55.CrossRefPubMed
46.
go back to reference ICRP. Radiation dose to patients from radiopharmaceuticals. Addendum 3 to ICRP Publication 53. ICRP Publication 106. Approved by the Commission in October 2007. Ann ICRP. 2008;38:1–197.CrossRefPubMed ICRP. Radiation dose to patients from radiopharmaceuticals. Addendum 3 to ICRP Publication 53. ICRP Publication 106. Approved by the Commission in October 2007. Ann ICRP. 2008;38:1–197.CrossRefPubMed
47.
go back to reference Doran MG, Spratt DE, Wongvipat J, Ulmert D, Carver BS, Sawyers CL, et al. Cabozantinib resolves bone scans in tumor-naive mice harboring skeletal injuries. Mol Imaging. 2014;13:7290.2014.00026. doi:10.2310/7290.2014.00026. Doran MG, Spratt DE, Wongvipat J, Ulmert D, Carver BS, Sawyers CL, et al. Cabozantinib resolves bone scans in tumor-naive mice harboring skeletal injuries. Mol Imaging. 2014;13:7290.2014.00026. doi:10.​2310/​7290.​2014.​00026.
48.
go back to reference Lassmann M, Treves ST. Paediatric radiopharmaceutical administration: harmonization of the 2007 EANM paediatric dosage card (version 1.5.2008) and the 2010 North American consensus guidelines. Eur J Nucl Med Mol Imaging. 2014;41:1036–41.CrossRefPubMed Lassmann M, Treves ST. Paediatric radiopharmaceutical administration: harmonization of the 2007 EANM paediatric dosage card (version 1.5.2008) and the 2010 North American consensus guidelines. Eur J Nucl Med Mol Imaging. 2014;41:1036–41.CrossRefPubMed
50.
go back to reference Busemann Sokole E, Plachcinska A, Britten A, Lyra Georgosopoulou M, Tindale W, Klett R. Routine quality control recommendations for nuclear medicine instrumentation. Eur J Nucl Med Mol Imaging. 2010;37:662–71.CrossRefPubMed Busemann Sokole E, Plachcinska A, Britten A, Lyra Georgosopoulou M, Tindale W, Klett R. Routine quality control recommendations for nuclear medicine instrumentation. Eur J Nucl Med Mol Imaging. 2010;37:662–71.CrossRefPubMed
51.
go back to reference Brown ML, O’Connor MK, Hung JC, Hayostek RJ. Technical aspects of bone scintigraphy. Radiol Clin North Am. 1993;31:721–30.PubMed Brown ML, O’Connor MK, Hung JC, Hayostek RJ. Technical aspects of bone scintigraphy. Radiol Clin North Am. 1993;31:721–30.PubMed
52.
go back to reference Schirrmeister H, Glatting G, Hetzel J, Nussle K, Arslandemir C, Buck AK, et al. Prospective evaluation of the clinical value of planar bone scans, SPECT, and (18)F-labeled NaF PET in newly diagnosed lung cancer. J Nucl Med. 2001;42:1800–4.PubMed Schirrmeister H, Glatting G, Hetzel J, Nussle K, Arslandemir C, Buck AK, et al. Prospective evaluation of the clinical value of planar bone scans, SPECT, and (18)F-labeled NaF PET in newly diagnosed lung cancer. J Nucl Med. 2001;42:1800–4.PubMed
53.
go back to reference Delbeke D, Coleman RE, Guiberteau MJ, Brown ML, Royal HD, Siegel BA, et al. Procedure guideline for SPECT/CT imaging 1.0. J Nucl Med. 2006;47:1227–34.PubMed Delbeke D, Coleman RE, Guiberteau MJ, Brown ML, Royal HD, Siegel BA, et al. Procedure guideline for SPECT/CT imaging 1.0. J Nucl Med. 2006;47:1227–34.PubMed
54.
go back to reference Palmedo H, Marx C, Ebert A, Kreft B, Ko Y, Turler A, et al. Whole-body SPECT/CT for bone scintigraphy: diagnostic value and effect on patient management in oncological patients. Eur J Nucl Med Mol Imaging. 2014;41:59–67.CrossRefPubMed Palmedo H, Marx C, Ebert A, Kreft B, Ko Y, Turler A, et al. Whole-body SPECT/CT for bone scintigraphy: diagnostic value and effect on patient management in oncological patients. Eur J Nucl Med Mol Imaging. 2014;41:59–67.CrossRefPubMed
55.
go back to reference Ryan CJ, Shah S, Efstathiou E, Smith MR, Taplin ME, Bubley GJ, et al. Phase II study of abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer displaying bone flare discordant with serologic response. Clin Cancer Res. 2011;17:4854–61.CrossRefPubMedPubMedCentral Ryan CJ, Shah S, Efstathiou E, Smith MR, Taplin ME, Bubley GJ, et al. Phase II study of abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer displaying bone flare discordant with serologic response. Clin Cancer Res. 2011;17:4854–61.CrossRefPubMedPubMedCentral
56.
go back to reference ICRP. Radiation dose to patients from radiopharmaceuticals (addendum to ICRP publication 53). ICRP publication 80. Ann ICRP. 1998;28:1–126. ICRP. Radiation dose to patients from radiopharmaceuticals (addendum to ICRP publication 53). ICRP publication 80. Ann ICRP. 1998;28:1–126.
57.
go back to reference Mettler Jr FA, Huda W, Yoshizumi TT, Mahesh M. Effective doses in radiology and diagnostic nuclear medicine: a catalog. Radiology. 2008;248:254–63.CrossRefPubMed Mettler Jr FA, Huda W, Yoshizumi TT, Mahesh M. Effective doses in radiology and diagnostic nuclear medicine: a catalog. Radiology. 2008;248:254–63.CrossRefPubMed
58.
go back to reference Brix G, Nekolla EA, Borowski M, Nosske D. Radiation risk and protection of patients in clinical SPECT/CT. Eur J Nucl Med Mol Imaging. 2014;41 Suppl 1:S125–36.CrossRefPubMed Brix G, Nekolla EA, Borowski M, Nosske D. Radiation risk and protection of patients in clinical SPECT/CT. Eur J Nucl Med Mol Imaging. 2014;41 Suppl 1:S125–36.CrossRefPubMed
Metadata
Title
The EANM practice guidelines for bone scintigraphy
Authors
T. Van den Wyngaert
K. Strobel
W. U. Kampen
T. Kuwert
W. van der Bruggen
H. K. Mohan
G. Gnanasegaran
R. Delgado-Bolton
W. A. Weber
M. Beheshti
W. Langsteger
F. Giammarile
F. M. Mottaghy
F. Paycha
On behalf of the EANM Bone & Joint Committee and the Oncology Committee.
Publication date
01-08-2016
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2016
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-016-3415-4

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