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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 01-09-2016 | Original Article

Nephrotoxicity after PRRT with ¹⁷⁷Lu-DOTA-octreotate

Authors: Hendrik Bergsma, Mark W. Konijnenberg, Wouter A. van der Zwan, Boen L. R. Kam, Jaap J. M. Teunissen, Peter P. Kooij, Katya A. L. Mauff, Eric P. Krenning, Dik J. Kwekkeboom

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2016

Abstract

Purpose

After peptide receptor radionuclide therapy (PRRT), renal toxicity may occur, particular in PRRT with ⁹⁰Y-labelled somatostatin analogues. Risk factors have been identified for increased probability of developing renal toxicity after PRRT, including hypertension, diabetes and age. We investigated the renal function over time, the incidence of nephrotoxicity and associated risk factors in patients treated with PRRT with [¹⁷⁷Lu-DOTA⁰,Tyr³]-Octreotate (¹⁷⁷Lu-Octreotate). Also, radiation dose to the kidneys was evaluated and compared with the accepted dose limits in external beam radiotherapy and PRRT with ⁹⁰Y-radiolabelled somatostatin analogues.

Methods

The annual decrease in creatinine clearance (CLR) was determined in 209 Dutch patients and the incidence of grade 3 or 4 renal toxicity (according to CTCAE v4.03) was evaluated in 323 patients. Risk factors were analysed using a nonlinear mixed effects regression model. Also, radiation doses to the kidneys were calculated and their association with high annual decrease in renal function were analysed.

Results

Of the 323 patients, 3 (1 %) developed (subacute) renal toxicity grade 2 (increase in serum creatinine >1.5 – 3.0 times baseline or upper limit of normal). No subacute grade 3 or 4 nephrotoxicity was observed. The estimated average baseline CLR (± SD) was 108 ± 5 ml/min and the estimated average annual decrease in CLR (± SD) was 3.4 ± 0.4 %. None of the risk factors (hypertension, diabetes, high cumulative injected activity, radiation dose to the kidneys and CTCAE grade) at baseline had a significant effect on renal function over time. The mean absorbed kidney dose in 228 patients was 20.1 ± 4.9 Gy.

Conclusion

Nephrotoxicity in patients treated with ¹⁷⁷Lu-octreotate was low. No (sub)acute grade 3 or 4 renal toxicity occurred and none of the patients had an annual decrease in renal function of >20 %. No risk factors for renal toxicity could be identified. Our data support the idea that the radiation dose threshold, adopted from external beam radiotherapy and PRRT with ⁹⁰Y-labelled somatostatin analogues, does not seem valid for PRRT with ¹⁷⁷Lu-octreotate.

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Title: Nephrotoxicity after PRRT with 177Lu-DOTA-octreotate
Authors: Hendrik Bergsma
Mark W. Konijnenberg
Wouter A. van der Zwan
Boen L. R. Kam
Jaap J. M. Teunissen
Peter P. Kooij
Katya A. L. Mauff
Eric P. Krenning
Dik J. Kwekkeboom
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2016
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-016-3382-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Nephrotoxicity after PRRT with ¹⁷⁷Lu-DOTA-octreotate

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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