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European Journal of Nuclear Medicine and Molecular Imaging

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01-03-2015 | Image of the Month

⁶⁸Ga-NOTA-exendin-4 PET/CT in detection of occult insulinoma and evaluation of physiological uptake

Authors: Yaping Luo, Miao Yu, QingQing Pan, Wenming Wu, Taiping Zhang, Dale O. Kiesewetter, Zhaohui Zhu, Fang Li, Xiaoyuan Chen, Yupei Zhao

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2015

Excerpt

A 52-year-old man who had hypoglycaemia for 8 years was found to have endogenous hyperinsulinism indicating an insulinoma. Abdominal MRI, CT perfusion, endoscopic ultrasonography, and ^99mTc-HYNIC-TOC SPECT/CT were negative. Thus, the patient was referred for ⁶⁸Ga-NOTA-exendin-4 PET/CT with the approval of the Institutional Review Board of our hospital. …

Korner M, Stockli M, Waser B, Reubi JC. GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting. J Nucl Med. 2007;48:736–43.CrossRefPubMed

Korner M, Christ E, Wild D, Reubi JC. Glucagon-like peptide-1 receptor overexpression in cancer and its impact on clinical applications. Front Endocrinol. 2012;3:158.CrossRef

Christ E, Wild D, Forrer F, Brandle M, Sahli R, Clerici T, et al. Glucagon-like peptide-1 receptor imaging for localization of insulinomas. J Clin Endocrinol Metab. 2009;94:4398–405.CrossRefPubMed

Sowa-Staszczak A, Pach D, Mikolajczak R, Macke H, Jabrocka-Hybel A, Stefanska A, et al. Glucagon-like peptide-1 receptor imaging with [Lys⁴⁰(Ahx-HYNIC- ^99mTc/EDDA)NH₂]-exendin-4 for the detection of insulinoma. Eur J Nucl Med Mol Imaging. 2013;40:524–31.CrossRefPubMedCentralPubMed

Eriksson O, Velikyan I, Selvaraju RK, Kandeel F, Johansson L, Antoni G, et al. Detection of metastatic insulinoma by positron emission tomography with [⁶⁸Ga]exendin-4 – a case report. J Clin Endocrinol Metab. 2014;99(5):1519–24.CrossRefPubMed

Title: 68Ga-NOTA-exendin-4 PET/CT in detection of occult insulinoma and evaluation of physiological uptake
Authors: Yaping Luo
Miao Yu
QingQing Pan
Wenming Wu
Taiping Zhang
Dale O. Kiesewetter
Zhaohui Zhu
Fang Li
Xiaoyuan Chen
Yupei Zhao
Publication date: 01-03-2015
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2015
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-014-2946-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

⁶⁸Ga-NOTA-exendin-4 PET/CT in detection of occult insulinoma and evaluation of physiological uptake

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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