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European Journal of Nuclear Medicine and Molecular Imaging

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01-12-2013 | Original Article

Reduced cardiac ¹²³I-metaiodobenzylguanidine uptake in patients with spinocerebellar ataxia type 2: a comparative study with Parkinson’s disease

Authors: Anna De Rosa, Sabina Pappatà, Teresa Pellegrino, Maria Fulvia De Leva, Gennaro Maddaluno, Giovanni Fiumara, Raffaella Carotenuto, Mario Petretta, Alessandro Filla, Giuseppe De Michele, Alberto Cuocolo

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 12/2013

Abstract

Purpose

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disorder characterized by cerebellar ataxia, supranuclear ophthalmoplegia, and peripheral neuropathy. Autonomic nervous system dysfunction is often present. This study evaluated the cardiac sympathetic function in patients with SCA2 using ¹²³I-metaiodobenzylguanidine (MIBG) in comparison with patients with Parkinson’s disease (PD) and control subjects.

Methods

Nine patients with SCA2, nine patients with PD, and nine control subjects underwent ¹²³I-MIBG imaging studies from which early and late heart-to-mediastinum (H/M) ratios and myocardial washout rates were calculated.

Results

Early (F = 12.3, p < 0.0001) and late (F = 16.8, p < 0.0001) H/M ratios were significantly different among groups. In controls, early and late H/M ratios (2.2 ± 0.12 and 2.1 ± 0.20) were significantly higher than in patients with SCA2 (1.9 ± 0.23 and 1.8 ± 0.20, both p < 0.05) and with patients with PD (1.7 ± 0.29 and 1.4 ± 0.35, both p < 0.001). There was also a significant difference in washout rates among groups (F = 11.7, p < 0.0001). In controls the washout rate (19.9 ± 9.6 %) was significantly lower (p < 0.005) than in patients with PD (51.0 ± 23.7 %), but not different from that in SCA2 patients (19.5 ± 9.4 %). In SCA2 patients, in a multivariable linear regression analysis only the Scale for the Assessment and Rating of Ataxia score was independently associated with early H/M ratio (β = −0.12, p < 0.05).

Conclusion

¹²³I-MIBG myocardial scintigraphy demonstrated an impairment of cardiac sympathetic function in patients with SCA2, which was less marked than in PD patients. These results suggest that ¹²³I-MIBG cardiac imaging could become a useful tool for analysing the pathophysiology of SCA2.

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Title: Reduced cardiac 123I-metaiodobenzylguanidine uptake in patients with spinocerebellar ataxia type 2: a comparative study with Parkinson’s disease
Authors: Anna De Rosa
Sabina Pappatà
Teresa Pellegrino
Maria Fulvia De Leva
Gennaro Maddaluno
Giovanni Fiumara
Raffaella Carotenuto
Mario Petretta
Alessandro Filla
Giuseppe De Michele
Alberto Cuocolo
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 12/2013
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-013-2524-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Reduced cardiac ¹²³I-metaiodobenzylguanidine uptake in patients with spinocerebellar ataxia type 2: a comparative study with Parkinson’s disease

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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