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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 01-08-2012 | Original Article

Parametric imaging of myocardial viability using ¹⁵O-labelled water and PET/CT: comparison with late gadolinium-enhanced CMR

Authors: Stefan de Haan, Hendrik J. Harms, Mark Lubberink, Cornelis P. Allaart, Ibrahim Danad, Weena J. Y. Chen, Michaela Diamant, Albert C. van Rossum, Hidehiro Iida, Adriaan A. Lammertsma, Paul Knaapen

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 8/2012

Abstract

Purpose

The perfusable tissue index (PTI) is a marker of myocardial viability. Recent technological advances have made it possible to generate parametric PTI images from a single [¹⁵O]H₂O PET/CT scan. The purpose of this study was to validate these parametric PTI images.

Methods

The study population comprised 46 patients with documented or suspected coronary artery disease who were studied with [¹⁵O]H₂O PET and late gadolinium-enhanced (LGE) cardiac magnetic resonance imaging (CMR).

Results

Of the 736 myocardial segments included, 364 showed some degree of LGE. PTI and perfusable tissue fraction (PTF) diminished with increasing LGE. The areas under the curve of the PTI and PTF, used to predict (near) transmural LGE on CMR, were 0.86 and 0.87, respectively. Optimal sensitivity and specificity were 91 % and 73 % for PTI and 69 % and 87 % for PTF, respectively.

Conclusion

PTI and PTF assessed with a single [¹⁵O]H₂O scan can be utilized as markers of myocardial viability in patients with coronary artery disease.

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Title: Parametric imaging of myocardial viability using 15O-labelled water and PET/CT: comparison with late gadolinium-enhanced CMR
Authors: Stefan de Haan
Hendrik J. Harms
Mark Lubberink
Cornelis P. Allaart
Ibrahim Danad
Weena J. Y. Chen
Michaela Diamant
Albert C. van Rossum
Hidehiro Iida
Adriaan A. Lammertsma
Paul Knaapen
Publication date: 01-08-2012
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 8/2012
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-012-2134-8

2024 ASCO Annual Meeting

Springer Medicine

Parametric imaging of myocardial viability using ¹⁵O-labelled water and PET/CT: comparison with late gadolinium-enhanced CMR

Abstract

Purpose

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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