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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 01-05-2011 | Review Article

Quantitative imaging of ¹²⁴I and ⁸⁶Y with PET

Authors: Mark Lubberink, Hans Herzog

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Special Issue 1/2011

Abstract

The quantitative accuracy and image quality of positron emission tomography (PET) measurements with ¹²⁴I and ⁸⁶Y is affected by the prompt emission of gamma radiation and positrons in their decays, as well as the higher energy of the emitted positrons compared to those emitted by ¹⁸F. PET scanners cannot distinguish between true coincidences, involving two 511-keV annihilation photons, and coincidences involving one annihilation photon and a prompt gamma, if the energy of this prompt gamma is within the energy window of the scanner. The current review deals with a number of aspects of the challenge this poses for quantitative PET imaging. First, the effect of prompt gamma coincidences on quantitative accuracy of PET images is discussed and a number of suggested corrections are described. Then, the effect of prompt gamma coincidences and the increased singles count rates due to gamma radiation on the count rate performance of PET is addressed, as well as possible improvements based on modification of the scanner’s energy windows. Finally, the effect of positron energy on spatial resolution and recovery is assessed. The methods presented in this overview aim to overcome the challenges associated with the decay characteristics of ¹²⁴I and ⁸⁶Y. Careful application of the presented correction methods can allow for quantitatively accurate images with improved image contrast.

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Title: Quantitative imaging of 124I and 86Y with PET
Authors: Mark Lubberink
Hans Herzog
Publication date: 01-05-2011
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue Special Issue 1/2011
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-011-1768-2

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Quantitative imaging of ¹²⁴I and ⁸⁶Y with PET

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