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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 12/2010

01-12-2010 | Editorial Commentary

On the effectiveness of recombinant human TSH as a stimulating agent for 131I treatment of metastatic differentiated thyroid cancer

Authors: Paolo Zanotti-Fregonara, Elif Hindié

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 12/2010

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Excerpt

Radiotherapy with 131I is the most effective treatment of iodine-avid metastases of differentiated thyroid cancer. Early diagnosis of metastases and repeated treatment with high activities of 131I improve outcome and allow complete remission in a substantial percentage of metastatic patients [1, 2]. However, treatment efficacy is subordinated to the ability of cancer cells to concentrate 131I. In patients whose metastases show no initial 131I uptake, the 10-year survival can be as low as 10% [3]. Therefore, before 131I administration, it is necessary to achieve high serum thyroid-stimulating hormone (TSH) levels in order to induce cancer cells to overexpress the sodium-iodide symporter, and thus enhance their iodine-trapping ability. …
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Hindié E, Zanotti-Fregonara P, Keller I, Duron F, Devaux JY, Calzada-Nocaudie M, et al. Bone metastases of differentiated thyroid cancer: impact of early 131I-based detection on outcome. Endocr Relat Cancer 2007;14:799–807.CrossRefPubMed
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Durante C, Haddy N, Baudin E, Leboulleux S, Hartl D, Travagli JP, et al. Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J Clin Endocrinol Metab 2006;91:2892–9.CrossRefPubMed
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Metadata
Title
On the effectiveness of recombinant human TSH as a stimulating agent for 131I treatment of metastatic differentiated thyroid cancer
Authors
Paolo Zanotti-Fregonara
Elif Hindié
Publication date
01-12-2010
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 12/2010
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-010-1608-9

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