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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 01-10-2009 | Original Article

Test-retest variability of quantitative [¹¹C]PIB studies in Alzheimer’s disease

Authors: Nelleke Tolboom, Maqsood Yaqub, Ronald Boellaard, Gert Luurtsema, Albert D. Windhorst, Philip Scheltens, Adriaan A. Lammertsma, Bart N. M. van Berckel

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2009

Abstract

Purpose

The aim of this study was to assess the test-retest variability of [¹¹C]PIB studies in patients with Alzheimer’s disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.

Methods

[¹¹C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.

Results

Test-retest variability was best (∼3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values (∼10%) were found for plasma input models. Cerebellar V_T values did not differ significantly between AD and controls.

Conclusion

Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [¹¹C]PIB PET studies.

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Title: Test-retest variability of quantitative [11C]PIB studies in Alzheimer’s disease
Authors: Nelleke Tolboom
Maqsood Yaqub
Ronald Boellaard
Gert Luurtsema
Albert D. Windhorst
Philip Scheltens
Adriaan A. Lammertsma
Bart N. M. van Berckel
Publication date: 01-10-2009
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2009
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-009-1129-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Test-retest variability of quantitative [¹¹C]PIB studies in Alzheimer’s disease

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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