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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-10-2009 | Original Article

¹⁸F-FDG PET/CT for early prediction of response to neoadjuvant chemotherapy in breast cancer

Authors: Joan Duch, David Fuster, Montserrat Muñoz, Pedro Luís Fernández, Pilar Paredes, Montserrat Fontanillas, Flavia Guzmán, Sebastià Rubí, Francisco Juan Lomeña, Francesca Pons

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2009

Abstract

Purpose

The aim of this study was to prospectively evaluate ¹⁸F-FDG PET/CT in predicting response to neoadjuvant chemotherapy in large primary breast cancer.

Methods

Fifty consecutive patients underwent PET/CT at baseline and after the second cycle. Baseline MRI was performed to establish tumour size. All findings were confirmed by histopathological analysis. Changes in maximum standardized uptake value (SUV_max) between baseline study and after two cycles of neoadjuvant chemotherapy (epirubicin + cyclophosphamide + taxanes) were compared using response evaluation criteria in solid tumours (RECIST) criteria and the Miller and Payne (M&P) scale.

Results

The mean tumour size was 4.3 ± 1.4 cm. Forty patients were considered responders and ten as non-responders. SUV_max changes in patients with good prognosis (M&P grades 4–5) were higher than in patients with bad prognosis (M&P grades 1–3) (p = 0.025). SUV_max changes between responders and non-responders following RECIST criteria were also statistically significant (p = 0.0028). A cut-off ΔSUV value of 40% differentiates both groups, with a sensitivity of 77% and a specificity of 80%.

Conclusion

¹⁸F-FDG PET/CT can predict response to neoadjuvant chemotherapy at an early stage.

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Title: 18F-FDG PET/CT for early prediction of response to neoadjuvant chemotherapy in breast cancer
Authors: Joan Duch
David Fuster
Montserrat Muñoz
Pedro Luís Fernández
Pilar Paredes
Montserrat Fontanillas
Flavia Guzmán
Sebastià Rubí
Francisco Juan Lomeña
Francesca Pons
Publication date: 01-10-2009
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2009
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-009-1116-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

¹⁸F-FDG PET/CT for early prediction of response to neoadjuvant chemotherapy in breast cancer

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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