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European Journal of Nuclear Medicine and Molecular Imaging

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01-03-2009 | Original Article

Positron emission tomography changes management and prognostic stratification in patients with oesophageal cancer: results of a multicentre prospective study

Authors: B. E. Chatterton, I. Ho Shon, A. Baldey, N. Lenzo, A. Patrikeos, B. Kelley, D. Wong, J. E. Ramshaw, A. M. Scott

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2009

Abstract

Objectives

The aims of this study were (1) to determine the incremental information provided by ¹⁸F-FDG positron emission tomography (PET) in staging patients with oesophageal cancer, and (2) to determine the impact of PET staging on post-PET clinical management of oesophageal cancer, and on prognosis.

Methods

In a multicentre, single-arm open study, patients with proved oesophageal cancer without definite distant metastases and regarded as suitable for potentially curative treatment were examined by PET. Clinicians were requested to supply a management plan before and another plan after being supplied with the PET scan results. Patients were followed for at least 1 year for outcome analysis.

Results

A total of 129 patients (104 men, mean age 67 y) were recruited. PET detected additional sites of disease in 53 patients (41%). Significant changes in management (high or medium impact) were observed in 38% of patients, primarily as a result of identifying additional sites of disease and/or confirming previously equivocal regional and distant metastases. Progression-free survival was significantly shorter in patients found to have additional lesions on PET (p < 0.05), but was not related to SUV_max.

Conclusion

These findings demonstrate the significant impact of PET on the clinical management of patients with newly diagnosed oesophageal carcinoma, and on prognostic stratification of these patients.

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Title: Positron emission tomography changes management and prognostic stratification in patients with oesophageal cancer: results of a multicentre prospective study
Authors: B. E. Chatterton
I. Ho Shon
A. Baldey
N. Lenzo
A. Patrikeos
B. Kelley
D. Wong
J. E. Ramshaw
A. M. Scott
Publication date: 01-03-2009
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2009
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-008-0959-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Positron emission tomography changes management and prognostic stratification in patients with oesophageal cancer: results of a multicentre prospective study

Abstract

Objectives

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

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