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European Journal of Nuclear Medicine and Molecular Imaging

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01-10-2008 | Original Article

Selective hepatic arterial infusion of In-111-DTPA-Phe¹-octreotide in neuroendocrine liver metastases

Authors: Georgios S. Limouris, Achilles Chatziioannou, Dimitrios Kontogeorgakos, Dimitrios Mourikis, Maria Lyra, Panagiotis Dimitriou, Anastasia Stavraka, Athanassios Gouliamos, Lambros Vlahos

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2008

Abstract

Purpose

The aim of this study is to evaluate the effectiveness of ¹¹¹In-DTPA-Phe¹-octreotide infusions after selective catheterization of the hepatic artery in inoperable metastasised liver, sst₂ receptor-positive neuroendocrine tumours due to the effect of ¹¹¹In Auger electron emission, minimising in parallel the toxicity of non-target tissue.

Methods

The average dose per session administered monthly to each patient (17 cases in total) was 6.3 ± 2.3 GBq. Repetitions did not exceed 12-fold, except in one case (15 sessions). Response assessment was classified according to the Response Evaluating Criteria in Solid Tumours. CT/MRI scans were performed as baseline before, during and after the end of treatment, and monthly ultrasound images for follow-up measurements. Toxicity (World Health Organization criteria) was measured using blood and urine tests of renal, hepatic and bone marrow function.

Results

Complete response was achieved in one (5.9%) patient and partial in eight (47.0%), and disease stabilization in 3 (17.7%) patients; five (29.4%) did not respond. A 32-month median survival time was estimated in 12 (70.5%). Nine of these 12 surviving had a mean target diameter shrinkage from 144 ± 81 to 60 ± 59 mm. Grade 1 erythro-, leuko- and thrombo-cytopenia occurred in three (17.6%) cases.

Conclusion

In unresectable metastatic liver lesions positive for somatostatin receptors repeated, transhepatic high doses of ¹¹¹In-DTPA-Phe¹-octreotide show an effective therapeutic outcome. Given the locoregional modality character of the administration technique plus the extremely short range of ¹¹¹In Auger and internal conversion electrons emission, no nephro-, liver- or myelo-toxicity has so far been observed.

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Title: Selective hepatic arterial infusion of In-111-DTPA-Phe1-octreotide in neuroendocrine liver metastases
Authors: Georgios S. Limouris
Achilles Chatziioannou
Dimitrios Kontogeorgakos
Dimitrios Mourikis
Maria Lyra
Panagiotis Dimitriou
Anastasia Stavraka
Athanassios Gouliamos
Lambros Vlahos
Publication date: 01-10-2008
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2008
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-008-0779-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Selective hepatic arterial infusion of In-111-DTPA-Phe¹-octreotide in neuroendocrine liver metastases

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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