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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-08-2005 | Original Article

Comparison of gray matter and metabolic reduction in mild Alzheimer’s disease using FDG-PET and voxel-based morphometric MR studies

Authors: Kazunari Ishii, Hiroki Sasaki, Atsushi K. Kono, Naokazu Miyamoto, Tetsuya Fukuda, Etsuro Mori

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 8/2005

Abstract

Purpose

The aim of this study was to investigate regional differences between morphologic and functional changes in the same patients with mild Alzheimer’s disease (AD) using statistical parametric mapping (SPM) and voxel-based morphometry (VBM).

Methods

Thirty patients with very mild AD (mean age 66.8 years, mean MMSE score 24.0) and 30 age- and sex-matched normal volunteers underwent both¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and three-dimensional spoiled gradient echo (SPGR) magnetic resonance imaging (MRI). Statistical parametric mapping was used to conduct VBM analysis of the morphological data, which were compared voxel by voxel with the results of a similar analysis of the glucose metabolic data.

Results

In AD patients, VBM data indicated a significant gray matter volume density decrease in bilateral amygdala/hippocampus complex (p<0.05, corrected), while FDG-PET analysis showed significant glucose metabolic reductions in the posterior cingulate gyri and the right parietal lobule, compared with those in the normal control group.

Conclusion

In very mild AD, morphological change occurs in the medial temporal lobes, while in contrast, metabolic changes occur in the posterior cingulate gyri and parietal lobule.

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Title: Comparison of gray matter and metabolic reduction in mild Alzheimer’s disease using FDG-PET and voxel-based morphometric MR studies
Authors: Kazunari Ishii
Hiroki Sasaki
Atsushi K. Kono
Naokazu Miyamoto
Tetsuya Fukuda
Etsuro Mori
Publication date: 01-08-2005
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 8/2005
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-004-1740-5

2024 ASCO Annual Meeting

Springer Medicine

Comparison of gray matter and metabolic reduction in mild Alzheimer’s disease using FDG-PET and voxel-based morphometric MR studies

Abstract

Purpose

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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