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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-04-2005 | Original Article

Clinical efficacy of radiation synovectomy in digital joint osteoarthritis

Authors: Willm Uwe Kampen, Leif Hellweg, Schirin Massoudi-Nickel, Norbert Czech, Winfried Brenner, Eberhard Henze

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 5/2005

Abstract

Purpose

Radiation synovectomy was developed for local treatment of rheumatoid arthritis. In this study, the long-term efficacy of radiation synovectomy was retrospectively evaluated in patients with osteoarthritis (activated arthrosis) of the digital joints using an algofunctional score.

Methods

Fifty-three digital joints in 29 patients (mean age 64.8 years) were treated by intra-articular injection of¹⁶⁹Er citrate. All joints were painful despite pharmacotherapy and showed an elevated blood pool pattern in a pretherapeutic three-phase bone scan, indicative for local synovitis. The patients were asked to classify their complaints with respect to different daily manual activities on a ten-step pain scale from 1 (total disability) to 10 (lack of any impairment) prior to and after treatment, with a mean follow-up of 41 months. Local signs of osteoarthritis such as joint swelling or pain were additionally evaluated and were scored from progression of complaints to excellent improvement based on patient self-evaluation.

Results

All patients reported a pronounced improvement in their manual activities. The mean total score of 4.73±0.58 for all activities prior to treatment increased significantly to 6.79±0.47 after radiation synovectomy (p<0.05). The best results were obtained in the thumb base joints, whereas distal interphalangeal joints were frequently resistant to therapy.

Conclusion

Radiation synovectomy is highly effective in digital joint osteoarthritis with concomitant local synovitis.

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Title: Clinical efficacy of radiation synovectomy in digital joint osteoarthritis
Authors: Willm Uwe Kampen
Leif Hellweg
Schirin Massoudi-Nickel
Norbert Czech
Winfried Brenner
Eberhard Henze
Publication date: 01-04-2005
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 5/2005
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-004-1712-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical efficacy of radiation synovectomy in digital joint osteoarthritis

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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