Published in:
01-10-2004 | Editorial Commentary
From the magic bullet to an effective therapy: the peptide experience
Author:
Luigi Mansi
Published in:
European Journal of Nuclear Medicine and Molecular Imaging
|
Issue 10/2004
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Excerpt
In this issue, Helisch et al. compare the pretherapeutic dosimetry and biodistribution of
86Y-DOTA-Phe
1-Tyr
3-octreotide versus
111In-pentetreotide in patients with advanced neuroendocrine tumours [
1]. This is the last of a series of recently published papers on peptides as valuable targeting agents for tumour diagnosis and therapy [
2]. For these purposes peptides have very favourable characteristics: excellent permeability, lack of antigenicity, minimal side-effects and rapid clearance from the body in the presence of high-affinity receptor binding; they are also easy to synthesise and modify chemically, to link to chelators and to radiolabel, creating an optimal system for in vivo diagnosis and therapy using radionuclides. This editorial commentary discusses information deriving from this biological model with a view to addressing the major issues involved in the passage from a wonderful theoretical universe to clinical practice in which the problems of patients with cancer need to be solved. …