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Published in: European Journal of Nuclear Medicine and Molecular Imaging 10/2003

01-10-2003 | Review Article

PET/CT: a new imaging technology in nuclear medicine

Authors: Heiko Schöder, Yusuf E. Erdi, Steven M. Larson, Henry W. D. Yeung

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2003

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Abstract

This review discusses the technical background of combined PET and CT and considers the clinical applications of PET/CT imaging. Questions addressed include: Is PET/CT superior to PET imaging alone? If so, in which patient populations and in what respect? Can PET/CT imaging affect patient management? Can PET/CT be practiced economically? While much work remains to be done, the available data clearly suggest that PET/CT decreases imaging time per patient and, even for the experienced reader, significantly reduces the number of equivocal PET interpretations. PET/CT also has the ability to improve accuracy of PET image interpretation and to affect clinical decision making, thereby improving patient management. The nuclear medicine community should approach this new technology with an open mind and focus on its clinical usefulness. The decision regarding whether PET/CT should be part of the equipment in a given nuclear medicine or radiology practice largely depends on the specific patient population. It is concluded that present skepticism concerning combined PET/CT will subside once critics of this new modality have had the opportunity to clearly see on images its many advantages compared with either PET alone or conventional image fusion approaches.
Literature
1.
go back to reference Phelps M. Positron emission tomography provides molecular imaging of biological processes. Proc Natl Acad Sci U S A 2000; 97:9226–9233.PubMed Phelps M. Positron emission tomography provides molecular imaging of biological processes. Proc Natl Acad Sci U S A 2000; 97:9226–9233.PubMed
2.
go back to reference Phelps ME. Positron computed tomography studies of cerebral glucose metabolism in man: theory and application in nuclear medicine. Semin Nucl Med 1981; 11:32–49.PubMed Phelps ME. Positron computed tomography studies of cerebral glucose metabolism in man: theory and application in nuclear medicine. Semin Nucl Med 1981; 11:32–49.PubMed
3.
go back to reference Gambhir SS, Schwaiger M, Huang SC, et al. Simple noninvasive quantification method for measuring myocardial glucose utilization in humans employing positron emission tomography and fluorine-18 deoxyglucose. J Nucl Med 1989; 30:359–366.PubMed Gambhir SS, Schwaiger M, Huang SC, et al. Simple noninvasive quantification method for measuring myocardial glucose utilization in humans employing positron emission tomography and fluorine-18 deoxyglucose. J Nucl Med 1989; 30:359–366.PubMed
4.
go back to reference Choi Y, Hawkins RA, Huang SC, et al. Parametric images of myocardial metabolic rate of glucose generated from dynamic cardiac PET and 2-[18F]fluoro-2-deoxy-d-glucose studies. J Nucl Med 1991; 32:733–738.PubMed Choi Y, Hawkins RA, Huang SC, et al. Parametric images of myocardial metabolic rate of glucose generated from dynamic cardiac PET and 2-[18F]fluoro-2-deoxy-d-glucose studies. J Nucl Med 1991; 32:733–738.PubMed
5.
go back to reference Nehmeh SA, Erdi YE, Ling CC, et al. Effect of respiratory gating on quantifying PET images of lung cancer. J Nucl Med 2002; 43:876–881. Nehmeh SA, Erdi YE, Ling CC, et al. Effect of respiratory gating on quantifying PET images of lung cancer. J Nucl Med 2002; 43:876–881.
6.
go back to reference Hattori N, Bengel FM, Mehilli J, et al. Global and regional functional measurements with gated FDG PET in comparison with left ventriculography. Eur J Nucl Med 2001; 28:221–229. Hattori N, Bengel FM, Mehilli J, et al. Global and regional functional measurements with gated FDG PET in comparison with left ventriculography. Eur J Nucl Med 2001; 28:221–229.
7.
go back to reference Melcher CL. Scintillation crystals for PET. J Nucl Med 2000; 41:1051–1055.PubMed Melcher CL. Scintillation crystals for PET. J Nucl Med 2000; 41:1051–1055.PubMed
8.
go back to reference Cherry S, Phelps M. Positron emission tomography: methods and instrumentation. In: Sandler M, Coleman RE, Patton J, Wackers F, Gottschalk A, eds. Diagnostic nuclear medicine. Philadelphia: Lippincott Williams and Wilkins; 2003:61–83. Cherry S, Phelps M. Positron emission tomography: methods and instrumentation. In: Sandler M, Coleman RE, Patton J, Wackers F, Gottschalk A, eds. Diagnostic nuclear medicine. Philadelphia: Lippincott Williams and Wilkins; 2003:61–83.
9.
go back to reference Fahey FH. Positron emission tomography instrumentation. Radiol Clin North Am 2001; 39:919–929.PubMed Fahey FH. Positron emission tomography instrumentation. Radiol Clin North Am 2001; 39:919–929.PubMed
10.
go back to reference Votaw JR, White M. Comparison of 2-dimensional and 3-dimensional cardiac82Rb PET studies. J Nucl Med 2001; 42:701–706.PubMed Votaw JR, White M. Comparison of 2-dimensional and 3-dimensional cardiac82Rb PET studies. J Nucl Med 2001; 42:701–706.PubMed
11.
go back to reference Burger C, Goerres G, Schoenes S, Buck A, Lonn AH, von Schulthess GK. PET attenuation coefficients from CT images: experimental evaluation of the transformation of CT into PET 511-keV attenuation coefficients. Eur J Nucl Med Mol Imaging 2002; 29:922–927.CrossRefPubMed Burger C, Goerres G, Schoenes S, Buck A, Lonn AH, von Schulthess GK. PET attenuation coefficients from CT images: experimental evaluation of the transformation of CT into PET 511-keV attenuation coefficients. Eur J Nucl Med Mol Imaging 2002; 29:922–927.CrossRefPubMed
12.
go back to reference Nakamoto Y, Osman M, Cohade C, et al. PET/CT: comparison of quantitative tracer uptake between germanium and CT transmission attenuation-corrected images. J Nucl Med 2002; 43:1137–1143. Nakamoto Y, Osman M, Cohade C, et al. PET/CT: comparison of quantitative tracer uptake between germanium and CT transmission attenuation-corrected images. J Nucl Med 2002; 43:1137–1143.
13.
go back to reference Visvikis D, Cheze-LeRest C, Costa DC, Bomanji J, Gacinovic S, Ell PJ. Influence of OSEM and segmented attenuation correction in the calculation of standardised uptake values for [18F]FDG PET. Eur J Nucl Med 2001; 28:1326–1335.PubMed Visvikis D, Cheze-LeRest C, Costa DC, Bomanji J, Gacinovic S, Ell PJ. Influence of OSEM and segmented attenuation correction in the calculation of standardised uptake values for [18F]FDG PET. Eur J Nucl Med 2001; 28:1326–1335.PubMed
14.
go back to reference Schoder H, Erdi Y, Chao K, Larson S, Yeung H. Clinical implications of the use of two image reconstruction algorithms for PET in cancer patients [abstract]. J Nucl Med 2002; 43:156p. Schoder H, Erdi Y, Chao K, Larson S, Yeung H. Clinical implications of the use of two image reconstruction algorithms for PET in cancer patients [abstract]. J Nucl Med 2002; 43:156p.
15.
go back to reference Townsend DW, Beyer T. A combined PET/CT scanner: the path to true image fusion. Br J Radiol 2002; 75 Spec No:S24–S30. Townsend DW, Beyer T. A combined PET/CT scanner: the path to true image fusion. Br J Radiol 2002; 75 Spec No:S24–S30.
16.
go back to reference Kluetz PG, Meltzer CC, Villemagne VL, et al. Combined PET/CT imaging in oncology. Impact on patient management. Clin Positron Imaging 2000; 3:223–230.PubMed Kluetz PG, Meltzer CC, Villemagne VL, et al. Combined PET/CT imaging in oncology. Impact on patient management. Clin Positron Imaging 2000; 3:223–230.PubMed
17.
go back to reference Yeung H, Schoder H, Larson S. Utility of PET/CT for assessing equivocal PET lesions in oncology—initial experience [abstract]. J Nucl Med 2002; 43:32P. Yeung H, Schoder H, Larson S. Utility of PET/CT for assessing equivocal PET lesions in oncology—initial experience [abstract]. J Nucl Med 2002; 43:32P.
18.
go back to reference Keidar Z, Bar-Shalom R, Guralnik L, et al. Hybrid imaging using PET/CT with18F-FDG in suspected recurrence of lung cancer: diagnostic value and impact on patient management. J Nucl Med 2002; 43:32P. Keidar Z, Bar-Shalom R, Guralnik L, et al. Hybrid imaging using PET/CT with18F-FDG in suspected recurrence of lung cancer: diagnostic value and impact on patient management. J Nucl Med 2002; 43:32P.
19.
go back to reference Picchio M, Landoni C, Messa C, Del Maschio A, Sironi S, Fazio F. CT-PET in patients with increasing tumor markers [abstract]. Radiology 2002; 225:659. Picchio M, Landoni C, Messa C, Del Maschio A, Sironi S, Fazio F. CT-PET in patients with increasing tumor markers [abstract]. Radiology 2002; 225:659.
20.
go back to reference Cohade C, Osman M, Pannu HK, Wahl RL. Uptake in supraclavicular area fat ("USA-Fat"): description on18F-FDG PET/CT. J Nucl Med 2003; 44:170–176.PubMed Cohade C, Osman M, Pannu HK, Wahl RL. Uptake in supraclavicular area fat ("USA-Fat"): description on18F-FDG PET/CT. J Nucl Med 2003; 44:170–176.PubMed
21.
go back to reference Hany TF, Gharehpapagh E, Kamel EM, Buck A, Himms-Hagen J, von Schulthess GK. Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur J Nucl Med Mol Imaging 2002; 29:1393–1398.CrossRefPubMed Hany TF, Gharehpapagh E, Kamel EM, Buck A, Himms-Hagen J, von Schulthess GK. Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur J Nucl Med Mol Imaging 2002; 29:1393–1398.CrossRefPubMed
22.
go back to reference Nakamoto Y, Cohade C, Osman M, Marshall L, Fishman E, Wahl R. Normal FDG distribution in head and neck region: PET/CT evaluation [abstract]. Radiology 2002; 225 (p):333. Nakamoto Y, Cohade C, Osman M, Marshall L, Fishman E, Wahl R. Normal FDG distribution in head and neck region: PET/CT evaluation [abstract]. Radiology 2002; 225 (p):333.
23.
go back to reference Yeung H, Grewal R, Gonen M, Schöder H, Larson SM. Patterns of FDG uptake in adipose tissue and muscle: a potential source of false positives for positron emission tomography. J Nucl Med 2003 (in press). Yeung H, Grewal R, Gonen M, Schöder H, Larson SM. Patterns of FDG uptake in adipose tissue and muscle: a potential source of false positives for positron emission tomography. J Nucl Med 2003 (in press).
24.
go back to reference Tatlidil R, Jadvar H, Bading JR, Conti PS. Incidental colonic fluorodeoxyglucose uptake: correlation with colonoscopic and histopathologic findings. Radiology 2002; 224:783–787.PubMed Tatlidil R, Jadvar H, Bading JR, Conti PS. Incidental colonic fluorodeoxyglucose uptake: correlation with colonoscopic and histopathologic findings. Radiology 2002; 224:783–787.PubMed
25.
go back to reference Schöder H, Yeung H, Larson S. Incremental diagnostic value of PET/CT fusion imaging in patients with head and neck malignancies [abstract]. Radiology 2002; 225 (p):333. Schöder H, Yeung H, Larson S. Incremental diagnostic value of PET/CT fusion imaging in patients with head and neck malignancies [abstract]. Radiology 2002; 225 (p):333.
26.
go back to reference Schöder H, Yeung H, Larson SM. Utility of PET/CT in patients with abdominal and pelvic malignancies [abstract]. Radiology 2002; 225 (p):659. Schöder H, Yeung H, Larson SM. Utility of PET/CT in patients with abdominal and pelvic malignancies [abstract]. Radiology 2002; 225 (p):659.
27.
go back to reference Hannah A, Scott AM, Tochon-Danguy H, et al. Evaluation of18F-fluorodeoxyglucose positron emission tomography and computed tomography with histopathologic correlation in the initial staging of head and neck cancer. Ann Surg 2002; 236:208–217.CrossRefPubMed Hannah A, Scott AM, Tochon-Danguy H, et al. Evaluation of18F-fluorodeoxyglucose positron emission tomography and computed tomography with histopathologic correlation in the initial staging of head and neck cancer. Ann Surg 2002; 236:208–217.CrossRefPubMed
28.
go back to reference Adams S, Baum R, Stuckensen T, Bitter K, Hör G. Prospective comparison of18F-FDG PET with conventional imaging modalities (CT<MRI<US) in lymph node staging of head and neck cancer. Eur J Nucl Med 1998; 25:1255–1260.CrossRefPubMed Adams S, Baum R, Stuckensen T, Bitter K, Hör G. Prospective comparison of18F-FDG PET with conventional imaging modalities (CT<MRI<US) in lymph node staging of head and neck cancer. Eur J Nucl Med 1998; 25:1255–1260.CrossRefPubMed
29.
go back to reference Kresnik E, Mikosch P, Gallowitsch HJ, et al. Evaluation of head and neck cancer with18F-FDG PET: a comparison with conventional methods. Eur J Nucl Med 2001; 28:816–821. Kresnik E, Mikosch P, Gallowitsch HJ, et al. Evaluation of head and neck cancer with18F-FDG PET: a comparison with conventional methods. Eur J Nucl Med 2001; 28:816–821.
30.
go back to reference Stokkel MP, ten Broek FW, Hordijk GJ, Koole R, van Rijk PP. Preoperative evaluation of patients with primary head and neck cancer using dual-head 18fluorodeoxyglucose positron emission tomography. Ann Surg 2000; 231:229–234.CrossRefPubMed Stokkel MP, ten Broek FW, Hordijk GJ, Koole R, van Rijk PP. Preoperative evaluation of patients with primary head and neck cancer using dual-head 18fluorodeoxyglucose positron emission tomography. Ann Surg 2000; 231:229–234.CrossRefPubMed
31.
go back to reference Lardinois D, Weder W, Hany TF, Kamel EM, Korom S, Seifert B, von Schulthess GK, Steinert HC. Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography. N Engl J Med 2003; 348:2500–2507.CrossRefPubMed Lardinois D, Weder W, Hany TF, Kamel EM, Korom S, Seifert B, von Schulthess GK, Steinert HC. Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography. N Engl J Med 2003; 348:2500–2507.CrossRefPubMed
32.
go back to reference Burger I, Goerres G, von Schulthess G, Seifert B, Hany T. PET/CT: diagnostic improvement in recurrent colorectal carcinoma compared to PET alone. Radiology 2002; 225 (p):424. Burger I, Goerres G, von Schulthess G, Seifert B, Hany T. PET/CT: diagnostic improvement in recurrent colorectal carcinoma compared to PET alone. Radiology 2002; 225 (p):424.
33.
go back to reference Akhurst T, Schoder H, Daftatry A, Lis E, Gonen M, Larson S. The addition of CT data increases the confidence of readers in the detection and grading of malignant bone lesions. Radiology 2002; 225 (p):275. Akhurst T, Schoder H, Daftatry A, Lis E, Gonen M, Larson S. The addition of CT data increases the confidence of readers in the detection and grading of malignant bone lesions. Radiology 2002; 225 (p):275.
34.
go back to reference Pannu HK, Cohade C, Fishman EK, Bristow R, Montz F, Wahl RL. Positron emission tomography/computed tomography (PET/CT) detection of chest metastases from ovarian cancer. Radiology 2002; 225 (p):479. Pannu HK, Cohade C, Fishman EK, Bristow R, Montz F, Wahl RL. Positron emission tomography/computed tomography (PET/CT) detection of chest metastases from ovarian cancer. Radiology 2002; 225 (p):479.
35.
go back to reference Heron D, Bhatnagar A, Blodgett T, Meltzer C, Townsend D, Yap J. PET/CT in staging and restaging patients with carcinoma of the uterine cervix. Radiology 2002; 225 (p):597. Heron D, Bhatnagar A, Blodgett T, Meltzer C, Townsend D, Yap J. PET/CT in staging and restaging patients with carcinoma of the uterine cervix. Radiology 2002; 225 (p):597.
36.
go back to reference Bhatnagar A, Heron D, Blodgett T, Meltzer C, Townsend D, Yapp J. Integrated PET/CT for restaging patients with ovarian carcinoma. Radiology 2002; 225 (p):599. Bhatnagar A, Heron D, Blodgett T, Meltzer C, Townsend D, Yapp J. Integrated PET/CT for restaging patients with ovarian carcinoma. Radiology 2002; 225 (p):599.
37.
go back to reference Mac Manus MP, Wong K, Hicks RJ, Matthews JP, Wirth A, Ball DL. Early mortality after radical radiotherapy for non-small-cell lung cancer: comparison of PET-staged and conventionally staged cohorts treated at a large tertiary referral center. Int J Radiat Oncol Biol Phys 2002; 52:351–361.PubMed Mac Manus MP, Wong K, Hicks RJ, Matthews JP, Wirth A, Ball DL. Early mortality after radical radiotherapy for non-small-cell lung cancer: comparison of PET-staged and conventionally staged cohorts treated at a large tertiary referral center. Int J Radiat Oncol Biol Phys 2002; 52:351–361.PubMed
38.
go back to reference Osman MM, Cohade C, Nakamoto Y, Marshall LT, Leal JP, Wahl RL. Clinically significant inaccurate localization of lesions with PET/CT: frequency in 300 patients. J Nucl Med 2003; 44:240–243.PubMed Osman MM, Cohade C, Nakamoto Y, Marshall LT, Leal JP, Wahl RL. Clinically significant inaccurate localization of lesions with PET/CT: frequency in 300 patients. J Nucl Med 2003; 44:240–243.PubMed
39.
go back to reference Cohade C, Osman M, Nakamoto Y, et al. Initial experience with oral contrast in PET/CT: phantom and clinical studies. J Nucl Med 2003; 44:412–416.PubMed Cohade C, Osman M, Nakamoto Y, et al. Initial experience with oral contrast in PET/CT: phantom and clinical studies. J Nucl Med 2003; 44:412–416.PubMed
40.
go back to reference Cohade C, Osman M, Marshall LT, Wahl RL. PET-CT: accuracy of PET and CT spatial registration of lung lesions. Eur J Nucl Med Mol Imaging 2003; 30:721–726.PubMed Cohade C, Osman M, Marshall LT, Wahl RL. PET-CT: accuracy of PET and CT spatial registration of lung lesions. Eur J Nucl Med Mol Imaging 2003; 30:721–726.PubMed
41.
go back to reference Osman MM, Cohade C, Nakamoto Y, Wahl RL. Respiratory motion artifacts on PET emission images obtained using CT attenuation correction on PET-CT. Eur J Nucl Med Mol Imaging 2003; 30:603–606.PubMed Osman MM, Cohade C, Nakamoto Y, Wahl RL. Respiratory motion artifacts on PET emission images obtained using CT attenuation correction on PET-CT. Eur J Nucl Med Mol Imaging 2003; 30:603–606.PubMed
42.
go back to reference Antoch G, Freudenberg LS, Stattaus J, et al. Whole-body positron emission tomography-CT: optimized CT using oral and IV contrast materials. AJR Am J Roentgenol 2002; 179:1555–1560.PubMed Antoch G, Freudenberg LS, Stattaus J, et al. Whole-body positron emission tomography-CT: optimized CT using oral and IV contrast materials. AJR Am J Roentgenol 2002; 179:1555–1560.PubMed
43.
go back to reference Antoch G, Freudenberg LS, Egelhof T, et al. Focal tracer uptake: a potential artifact in contrast-enhanced dual-modality PET/CT scans. J Nucl Med 2002; 43:1339–1342.PubMed Antoch G, Freudenberg LS, Egelhof T, et al. Focal tracer uptake: a potential artifact in contrast-enhanced dual-modality PET/CT scans. J Nucl Med 2002; 43:1339–1342.PubMed
44.
go back to reference Goerres GW, von Schulthess GK, Hany TF. Positron emission tomography and PET CT of the head and neck: FDG uptake in normal anatomy, in benign lesions, and in changes resulting from treatment. AJR Am J Roentgenol 2002; 179:1337–1343.PubMed Goerres GW, von Schulthess GK, Hany TF. Positron emission tomography and PET CT of the head and neck: FDG uptake in normal anatomy, in benign lesions, and in changes resulting from treatment. AJR Am J Roentgenol 2002; 179:1337–1343.PubMed
45.
go back to reference Dizendorf EV, Treyer V, von Schulthess GK, Hany TF. Application of oral contrast media in coregistered positron emission tomography-CT. AJR Am J Roentgenol 2002; 179:477–481.PubMed Dizendorf EV, Treyer V, von Schulthess GK, Hany TF. Application of oral contrast media in coregistered positron emission tomography-CT. AJR Am J Roentgenol 2002; 179:477–481.PubMed
46.
go back to reference Goerres GW, Hany TF, Kamel E, von Schulthess GK, Buck A. Head and neck imaging with PET and PET/CT: artifacts from dental metallic implants. Eur J Nucl Med Mol Imaging 2002; 29:367–370.CrossRefPubMed Goerres GW, Hany TF, Kamel E, von Schulthess GK, Buck A. Head and neck imaging with PET and PET/CT: artifacts from dental metallic implants. Eur J Nucl Med Mol Imaging 2002; 29:367–370.CrossRefPubMed
47.
go back to reference Goerres GW, Ziegler SI, Burger C, Berthold T, von Schulthess GK, Buck A. Artifacts at PET and PET/CT caused by metallic hip prosthetic material. Radiology 2003; 226:577–584.PubMed Goerres GW, Ziegler SI, Burger C, Berthold T, von Schulthess GK, Buck A. Artifacts at PET and PET/CT caused by metallic hip prosthetic material. Radiology 2003; 226:577–584.PubMed
48.
go back to reference Kamel EM, Goerres GW, Burger C, von Schulthess GK, Steinert HC. Recurrent laryngeal nerve palsy in patients with lung cancer: detection with PET-CT image fusion—report of six cases. Radiology 2002; 224:153–156.PubMed Kamel EM, Goerres GW, Burger C, von Schulthess GK, Steinert HC. Recurrent laryngeal nerve palsy in patients with lung cancer: detection with PET-CT image fusion—report of six cases. Radiology 2002; 224:153–156.PubMed
49.
go back to reference Kamel EM, Burger C, Buck A, von Schulthess GM, Goerres GM. Impact of metallic dental implants on CT-based attenuation correction in a combined PET/CT scanner. Eur Radiol 2003; 13:724–728.PubMed Kamel EM, Burger C, Buck A, von Schulthess GM, Goerres GM. Impact of metallic dental implants on CT-based attenuation correction in a combined PET/CT scanner. Eur Radiol 2003; 13:724–728.PubMed
50.
go back to reference Dizendorf E, Hany TF, Buck A, von Schulthess GK, Burger C. Cause and magnitude of the error induced by oral CT contrast agent in CT-based attenuation correction of PET emission studies. J Nucl Med 2003; 44:732–738.PubMed Dizendorf E, Hany TF, Buck A, von Schulthess GK, Burger C. Cause and magnitude of the error induced by oral CT contrast agent in CT-based attenuation correction of PET emission studies. J Nucl Med 2003; 44:732–738.PubMed
51.
go back to reference Nakamoto Y, Tatsumi M, Cohade C, Osman M, Marshall LT, Wahl RL. Accuracy of image fusion of normal upper abdominal organs visualized with PET/CT. Eur J Nucl Med Mol Imaging 2003; 30:597–602.PubMed Nakamoto Y, Tatsumi M, Cohade C, Osman M, Marshall LT, Wahl RL. Accuracy of image fusion of normal upper abdominal organs visualized with PET/CT. Eur J Nucl Med Mol Imaging 2003; 30:597–602.PubMed
52.
go back to reference Goerres GW, Kamel E, Heidelberg TN, Schwitter MR, Burger C, von Schulthess GK. PET-CT image co-registration in the thorax: influence of respiration. Eur J Nucl Med Mol Imaging 2002; 29:351–360.CrossRefPubMed Goerres GW, Kamel E, Heidelberg TN, Schwitter MR, Burger C, von Schulthess GK. PET-CT image co-registration in the thorax: influence of respiration. Eur J Nucl Med Mol Imaging 2002; 29:351–360.CrossRefPubMed
53.
go back to reference Beyer T, Antoch G, Blodgett T, Freudenberg LF, Akhurst T, Mueller S. Dual-modality PET/CT imaging: the effect of respiratory motion on combined image quality in clinical oncology. Eur J Nucl Med Mol Imaging 2003; 30:588–596.PubMed Beyer T, Antoch G, Blodgett T, Freudenberg LF, Akhurst T, Mueller S. Dual-modality PET/CT imaging: the effect of respiratory motion on combined image quality in clinical oncology. Eur J Nucl Med Mol Imaging 2003; 30:588–596.PubMed
54.
go back to reference Barrington SF, Maisey MN. Skeletal muscle uptake of fluorine-18-FDG: effect of oral diazepam. J Nucl Med 1996; 37:1127–1129.PubMed Barrington SF, Maisey MN. Skeletal muscle uptake of fluorine-18-FDG: effect of oral diazepam. J Nucl Med 1996; 37:1127–1129.PubMed
55.
go back to reference Christy M, Eckerman K. Specific absorbed fractions of energy at various ages from internal photon sources. I.Methods. Oakridge National Laboratory-TM-8381 1987:1–100. Christy M, Eckerman K. Specific absorbed fractions of energy at various ages from internal photon sources. I.Methods. Oakridge National Laboratory-TM-8381 1987:1–100.
56.
go back to reference Prasad SR, Wittram C, Shepard JA, McLoud T, Rhea J. Standard-dose and 50%-reduced-dose chest CT: comparing the effect on image quality. AJR Am J Roentgenol 2002; 179:461–465.PubMed Prasad SR, Wittram C, Shepard JA, McLoud T, Rhea J. Standard-dose and 50%-reduced-dose chest CT: comparing the effect on image quality. AJR Am J Roentgenol 2002; 179:461–465.PubMed
57.
go back to reference Kalra MK, Prasad S, Saini S, et al. Clinical comparison of standard-dose and 50% reduced-dose abdominal CT: effect on image quality. AJR Am J Roentgenol 2002; 179:1101–1106.PubMed Kalra MK, Prasad S, Saini S, et al. Clinical comparison of standard-dose and 50% reduced-dose abdominal CT: effect on image quality. AJR Am J Roentgenol 2002; 179:1101–1106.PubMed
58.
59.
go back to reference Czernin J, Phelps ME. Positron emission tomography scanning: current and future applications. Annu Rev Med 2002; 53:89–112.PubMed Czernin J, Phelps ME. Positron emission tomography scanning: current and future applications. Annu Rev Med 2002; 53:89–112.PubMed
60.
go back to reference Delbeke D. Oncological applications of FDG PET imaging. J Nucl Med 1999; 40:1706–1715.PubMed Delbeke D. Oncological applications of FDG PET imaging. J Nucl Med 1999; 40:1706–1715.PubMed
61.
go back to reference Delbeke D. Oncological applications of FDG PET imaging: brain tumors, colorectal cancer, lymphoma and melanoma. J Nucl Med 1999; 40:591–603.PubMed Delbeke D. Oncological applications of FDG PET imaging: brain tumors, colorectal cancer, lymphoma and melanoma. J Nucl Med 1999; 40:591–603.PubMed
62.
go back to reference von Schulthess GK. Cost considerations regarding an integrated CT-PET system. Eur Radiol 2000; 10 Suppl 3:S377–S380. von Schulthess GK. Cost considerations regarding an integrated CT-PET system. Eur Radiol 2000; 10 Suppl 3:S377–S380.
Metadata
Title
PET/CT: a new imaging technology in nuclear medicine
Authors
Heiko Schöder
Yusuf E. Erdi
Steven M. Larson
Henry W. D. Yeung
Publication date
01-10-2003
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2003
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-003-1299-6

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