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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 3/2003

01-03-2003 | Short Communication

The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder

Authors: Claudia M. Szobot, Carla Ketzer, Renato D. Cunha, Maria A. Parente, Daniel D. Langleben, Paul D. Acton, Flávio Kapczinski, Luis A. P. Rohde

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2003

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Abstract

Methylphenidate (MPH) is the most commonly prescribed treatment for attention-deficit/hyperactivity disorder (ADHD). The therapeutic mechanisms of MPH are not, however, fully understood. We studied the effects of MPH on brain activity in male children and adolescents with ADHD, using the blood flow radiotracer technetium-99m ethyl cysteinate dimer (99mTc-ECD) and single-photon emission tomography (SPET) . The study was randomized, double blind, and placebo controlled (MPH group, n=19; placebo group, n=17), Radiotracer was administered during the performance of the Continuous Performance Test and before and after 4 days of MPH treatment. Statistical parametric mapping (SPM99) analysis showed a significant reduction in regional cerebral blood flow in the left parietal region in the MPH group compared with the placebo group (P<0.05, corrected for multiple comparisons). Our findings suggest that the posterior attentional system, which includes the parietal cortex, may have a role in the mediation of the therapeutic effects of MPH in ADHD.
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Metadata
Title
The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder
Authors
Claudia M. Szobot
Carla Ketzer
Renato D. Cunha
Maria A. Parente
Daniel D. Langleben
Paul D. Acton
Flávio Kapczinski
Luis A. P. Rohde
Publication date
01-03-2003
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2003
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-002-1082-0

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