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Published in: Skeletal Radiology 12/2018

01-12-2018 | Scientific Article

Comparison of three CT-guided epidural steroid injection approaches in 104 patients with cervical radicular pain: transforaminal anterolateral, posterolateral, and transfacet indirect

Authors: Sylvain Bise, Lionel Pesquer, Mathieu Feldis, Myriam Bou Antoun, Alain Silvestre, Arnaud Hocquelet, Benjamin Dallaudière

Published in: Skeletal Radiology | Issue 12/2018

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Abstract

Introduction

The treatment of persistent cervical radicular pain (CRP) by CT-guided epidural steroid injections (CTESI) by a transforaminal anterolateral (TFA) approach is associated with rare but serious complications. Two recently described transforaminal posterolateral (TFP) and transfacet indirect (TFT) approaches may be safer options, but have not been extensively evaluated. We compared the efficacy of three CTESI approaches (TFA, TFP, and TFT) in the treatment of persistent CRP (>6 weeks).

Methods

Patients were prospectively assessed for pain using the visual analog scale (VAS) and for functional disability by the Neck Disability Index (NDI) before treatment, then 6 weeks and 6 months after CTESI.

Results

A total of 104 patients were included (n = 30 TFA, n = 36 TFP, and n = 38 TFT approaches). Each group was found to have a statistically significant improvement at 6 weeks (median VAS values: 7 (2–9) at D0 and 2 (3–6) at 6 weeks p < 0.01; median NDI values: 38 (24–50) at D0 and 29 (18–42) at 6 weeks (p < 0.01)), and at 6 months (median VAS values: 7 (2–9) at D0 and 4 (2–6) at 6 months (p < 0.01); median NDI values: 38 (24–50) at D0 and 28 (13–40) at 6 months (p < 0.01)). No significant difference was observed in the decrease in VAS and NDI scores among the three approaches at 6 weeks (p = 0.635 and p = 0.54 for VAS and NDI respectively) or 6 months (p = 0.704 and p = 0.315 for VAS and NDI respectively). No major complications were noted.

Conclusion

The results of CTESI using the TFP or TFT approach are similar to those for TFA in the treatment of persistent CRP and could be a safer option.
Literature
1.
go back to reference US Burden of Disease Collaborators. The state of US health, 1990–2010: burden of diseases, injuries, and risk factors. JAMA. 2013;310:591–608.CrossRef US Burden of Disease Collaborators. The state of US health, 1990–2010: burden of diseases, injuries, and risk factors. JAMA. 2013;310:591–608.CrossRef
2.
go back to reference Martin BI, Deyo RA, Mirza SK, Turner JA, Comstock BA, Hollingworth W, et al. Expenditures and health status among adults with back and neck problems. JAMA. 2008;299:656–64.CrossRef Martin BI, Deyo RA, Mirza SK, Turner JA, Comstock BA, Hollingworth W, et al. Expenditures and health status among adults with back and neck problems. JAMA. 2008;299:656–64.CrossRef
3.
go back to reference Radhakrishnan K, Litchy WJ, O’Fallon WM, Kurland LT. Epidemiology of cervical radiculopathy. A population-based study from Rochester, Minnesota, 1976 through 1990. Brain J Neurol. 1994;117(Pt 2):325–35.CrossRef Radhakrishnan K, Litchy WJ, O’Fallon WM, Kurland LT. Epidemiology of cervical radiculopathy. A population-based study from Rochester, Minnesota, 1976 through 1990. Brain J Neurol. 1994;117(Pt 2):325–35.CrossRef
4.
go back to reference Huston CW. Cervical epidural steroid injections in the management of cervical radiculitis: interlaminar versus transforaminal. A review. Curr Rev Musculoskelet Med. 2009;2:30–42.CrossRef Huston CW. Cervical epidural steroid injections in the management of cervical radiculitis: interlaminar versus transforaminal. A review. Curr Rev Musculoskelet Med. 2009;2:30–42.CrossRef
5.
go back to reference Cyteval C, Thomas E, Decoux E, Sarrabere M-P, Cottin A, Blotman F, et al. Cervical radiculopathy: open study on percutaneous periradicular foraminal steroid infiltration performed under CT control in 30 patients. AJNR Am J Neuroradiol. 2004;25:441–5.PubMed Cyteval C, Thomas E, Decoux E, Sarrabere M-P, Cottin A, Blotman F, et al. Cervical radiculopathy: open study on percutaneous periradicular foraminal steroid infiltration performed under CT control in 30 patients. AJNR Am J Neuroradiol. 2004;25:441–5.PubMed
6.
go back to reference Vanzundert J, Harney D, Joosten E, Durieux M, Patijn J, Prins M, et al. The role of the dorsal root ganglion in cervical radicular pain: diagnosis, pathophysiology, and rationale for treatment. Reg Anesth Pain Med. 2006;31:152–67.CrossRef Vanzundert J, Harney D, Joosten E, Durieux M, Patijn J, Prins M, et al. The role of the dorsal root ganglion in cervical radicular pain: diagnosis, pathophysiology, and rationale for treatment. Reg Anesth Pain Med. 2006;31:152–67.CrossRef
7.
go back to reference Manchikanti L, Cash KA, Pampati V, Wargo BW, Malla Y. A randomized, double-blind, active control trial of fluoroscopic cervical interlaminar epidural injections in chronic pain of cervical disc herniation: results of a 2-year follow-up. Pain Physician. 2013;16:465–78.PubMed Manchikanti L, Cash KA, Pampati V, Wargo BW, Malla Y. A randomized, double-blind, active control trial of fluoroscopic cervical interlaminar epidural injections in chronic pain of cervical disc herniation: results of a 2-year follow-up. Pain Physician. 2013;16:465–78.PubMed
8.
go back to reference Anderberg L, Annertz M, Persson L, Brandt L, Säveland H. Transforaminal steroid injections for the treatment of cervical radiculopathy: a prospective and randomised study. Eur Spine J. 2007;16:321–8.CrossRef Anderberg L, Annertz M, Persson L, Brandt L, Säveland H. Transforaminal steroid injections for the treatment of cervical radiculopathy: a prospective and randomised study. Eur Spine J. 2007;16:321–8.CrossRef
9.
go back to reference Pottecher P, Krausé D, Di Marco L, Loffroy R, Estivalet L, Duhal R, et al. Cervical foraminal steroid injections under CT guidance: retrospective study of in situ contrast aspects in a serial of 248 cases. Skeletal Radiol. 2015;44:1–8.CrossRef Pottecher P, Krausé D, Di Marco L, Loffroy R, Estivalet L, Duhal R, et al. Cervical foraminal steroid injections under CT guidance: retrospective study of in situ contrast aspects in a serial of 248 cases. Skeletal Radiol. 2015;44:1–8.CrossRef
10.
go back to reference Diwan S, Manchikanti L, Benyamin RM, Bryce DA, Geffert S, Hameed H, et al. Effectiveness of cervical epidural injections in the management of chronic neck and upper extremity pain. Pain Physician. 2012;15:E405–34.PubMed Diwan S, Manchikanti L, Benyamin RM, Bryce DA, Geffert S, Hameed H, et al. Effectiveness of cervical epidural injections in the management of chronic neck and upper extremity pain. Pain Physician. 2012;15:E405–34.PubMed
11.
go back to reference Benyamin RM, Singh V, Parr AT, Conn A, Diwan S, Abdi S. Systematic review of the effectiveness of cervical epidurals in the management of chronic neck pain. Pain Physician. 2009;12:137–57.PubMed Benyamin RM, Singh V, Parr AT, Conn A, Diwan S, Abdi S. Systematic review of the effectiveness of cervical epidurals in the management of chronic neck pain. Pain Physician. 2009;12:137–57.PubMed
12.
go back to reference Brunner P, Amoretti N, Soares F, Brunner E, Cazaux É, Brocq O, et al. Approaches in injections for radicular pain: the transforaminal, epidural and transfacet approaches. Diagn Interv Imaging. 2012;93:711–22.CrossRef Brunner P, Amoretti N, Soares F, Brunner E, Cazaux É, Brocq O, et al. Approaches in injections for radicular pain: the transforaminal, epidural and transfacet approaches. Diagn Interv Imaging. 2012;93:711–22.CrossRef
13.
go back to reference Desai A, Saha S, Sharma N, Huckerby L, Houghton R. The short- and medium-term effectiveness of CT-guided selective cervical nerve root injection for pain and disability. Skeletal Radiol. 2014;43:973–8.CrossRef Desai A, Saha S, Sharma N, Huckerby L, Houghton R. The short- and medium-term effectiveness of CT-guided selective cervical nerve root injection for pain and disability. Skeletal Radiol. 2014;43:973–8.CrossRef
14.
go back to reference Rosenkranz M, Grzyska U, Niesen W, Fuchs K, Schummer W, Weiller C, et al. Anterior spinal artery syndrome following periradicular cervical nerve root therapy. J Neurol. 2004;251:229–31.CrossRef Rosenkranz M, Grzyska U, Niesen W, Fuchs K, Schummer W, Weiller C, et al. Anterior spinal artery syndrome following periradicular cervical nerve root therapy. J Neurol. 2004;251:229–31.CrossRef
15.
go back to reference Brouwers PJ, Kottink EJ, Simon MA, Prevo RL. A cervical anterior spinal artery syndrome after diagnostic blockade of the right C6-nerve root. Pain. 2001;91:397–9.CrossRef Brouwers PJ, Kottink EJ, Simon MA, Prevo RL. A cervical anterior spinal artery syndrome after diagnostic blockade of the right C6-nerve root. Pain. 2001;91:397–9.CrossRef
16.
go back to reference Scanlon GC, Moeller-Bertram T, Romanowsky SM, Wallace MS. Cervical transforaminal epidural steroid injections: more dangerous than we think? Spine. 2007;32:1249–56.CrossRef Scanlon GC, Moeller-Bertram T, Romanowsky SM, Wallace MS. Cervical transforaminal epidural steroid injections: more dangerous than we think? Spine. 2007;32:1249–56.CrossRef
17.
go back to reference Benny B, Azari P, Briones D. Complications of cervical transforaminal epidural steroid injections. Am J Phys Med Rehab. 2010;89:601–7.CrossRef Benny B, Azari P, Briones D. Complications of cervical transforaminal epidural steroid injections. Am J Phys Med Rehab. 2010;89:601–7.CrossRef
18.
go back to reference Malhotra G, Abbasi A, Rhee M. Complications of transforaminal cervical epidural steroid injections. Spine. 2009;34:731–9.CrossRef Malhotra G, Abbasi A, Rhee M. Complications of transforaminal cervical epidural steroid injections. Spine. 2009;34:731–9.CrossRef
19.
go back to reference Wolter T, Knoeller S, Berlis A, Hader C. CT-guided cervical selective nerve root block with a dorsal approach. AJNR Am J Neuroradiol. 2010;31:1831–6.CrossRef Wolter T, Knoeller S, Berlis A, Hader C. CT-guided cervical selective nerve root block with a dorsal approach. AJNR Am J Neuroradiol. 2010;31:1831–6.CrossRef
20.
go back to reference Wald JT, Maus TP, Geske JR, Carter RE, Diehn FE, Kaufmann TJ, et al. Safety and efficacy of CT-guided transforaminal cervical epidural steroid injections using a posterior approach. Am J Neuroradiol. 2012;33:415–9.CrossRef Wald JT, Maus TP, Geske JR, Carter RE, Diehn FE, Kaufmann TJ, et al. Safety and efficacy of CT-guided transforaminal cervical epidural steroid injections using a posterior approach. Am J Neuroradiol. 2012;33:415–9.CrossRef
21.
go back to reference Sutter R, Pfirrmann CWA, Zanetti M, Hodler J, Peterson CK. CT-guided cervical nerve root injections: comparing the immediate post-injection anesthetic-related effects of the transforaminal injection with a new indirect technique. Skeletal Radiol. 2011;40:1603–8.CrossRef Sutter R, Pfirrmann CWA, Zanetti M, Hodler J, Peterson CK. CT-guided cervical nerve root injections: comparing the immediate post-injection anesthetic-related effects of the transforaminal injection with a new indirect technique. Skeletal Radiol. 2011;40:1603–8.CrossRef
22.
go back to reference Bureau NJ, Moser T, Dagher JH, Shedid D, Li M, Brassard P, et al. Transforaminal versus intra-articular facet corticosteroid injections for the treatment of cervical radiculopathy: a randomized, double-blind, controlled study. AJNR Am J Neuroradiol. 2014;35:1467–74.CrossRef Bureau NJ, Moser T, Dagher JH, Shedid D, Li M, Brassard P, et al. Transforaminal versus intra-articular facet corticosteroid injections for the treatment of cervical radiculopathy: a randomized, double-blind, controlled study. AJNR Am J Neuroradiol. 2014;35:1467–74.CrossRef
23.
go back to reference Bensler S, Sutter R, Pfirrmann CWA, Peterson CK. Long term outcomes from CT-guided indirect cervical nerve root blocks and their relationship to the MRI findings—a prospective study. Eur Radiol. 2015;25:3405–13.CrossRef Bensler S, Sutter R, Pfirrmann CWA, Peterson CK. Long term outcomes from CT-guided indirect cervical nerve root blocks and their relationship to the MRI findings—a prospective study. Eur Radiol. 2015;25:3405–13.CrossRef
24.
go back to reference Bouhassira D, Attal N, Fermanian J, Alchaar H, Gautron M, Masquelier E, et al. Development and validation of the neuropathic pain symptom inventory. Pain. 2004;108:248–57.CrossRef Bouhassira D, Attal N, Fermanian J, Alchaar H, Gautron M, Masquelier E, et al. Development and validation of the neuropathic pain symptom inventory. Pain. 2004;108:248–57.CrossRef
25.
go back to reference Wlodyka-Demaille S, Poiraudeau S, Catanzariti J-F, Rannou F, Fermanian J, Revel M. French translation and validation of 3 functional disability scales for neck pain. Arch Phys Med Rehabil. 2002;83:376–82.CrossRef Wlodyka-Demaille S, Poiraudeau S, Catanzariti J-F, Rannou F, Fermanian J, Revel M. French translation and validation of 3 functional disability scales for neck pain. Arch Phys Med Rehabil. 2002;83:376–82.CrossRef
26.
go back to reference Park CH, Lee S-H. Contrast dispersion pattern and efficacy of computed tomography-guided cervical transforaminal epidural steroid injection. Pain Physician. 2014;17:487–92.PubMed Park CH, Lee S-H. Contrast dispersion pattern and efficacy of computed tomography-guided cervical transforaminal epidural steroid injection. Pain Physician. 2014;17:487–92.PubMed
27.
go back to reference Wald JT, Maus TP, Diehn FE, Kaufmann TJ, Morris JM, Murthy NS, et al. CT-guided cervical transforaminal epidural steroid injections: technical insights. J Neuroradiol. 2014;41:211–5.CrossRef Wald JT, Maus TP, Diehn FE, Kaufmann TJ, Morris JM, Murthy NS, et al. CT-guided cervical transforaminal epidural steroid injections: technical insights. J Neuroradiol. 2014;41:211–5.CrossRef
28.
go back to reference Kim K-H, Choi S-H, Kim T-K, Shin S-W, Kim C-H, Kim J-I. Cervical facet joint injections in the neck and shoulder pain. J Korean Med Sci. 2005;20:659–62.CrossRef Kim K-H, Choi S-H, Kim T-K, Shin S-W, Kim C-H, Kim J-I. Cervical facet joint injections in the neck and shoulder pain. J Korean Med Sci. 2005;20:659–62.CrossRef
29.
go back to reference Laemmel E, Segal N, Mirshahi M, Azzazene D, Le Marchand S, Wybier M, et al. Deleterious effects of intra-arterial administration of particulate steroids on microvascular perfusion in a mouse model. Radiology. 2016;279:731–40.CrossRef Laemmel E, Segal N, Mirshahi M, Azzazene D, Le Marchand S, Wybier M, et al. Deleterious effects of intra-arterial administration of particulate steroids on microvascular perfusion in a mouse model. Radiology. 2016;279:731–40.CrossRef
30.
go back to reference Moon J, Kwon H-M. Spinal cord infarction after cervical transforaminal epidural steroid injection: case report and literature review. Case Rep Neurol. 2017;9:1–5.CrossRef Moon J, Kwon H-M. Spinal cord infarction after cervical transforaminal epidural steroid injection: case report and literature review. Case Rep Neurol. 2017;9:1–5.CrossRef
31.
go back to reference Wybier M. Transforaminal epidural corticosteroid injections and spinal cord infarction. Jt Bone Spine Rev Rhum. 2008;75:523–5.CrossRef Wybier M. Transforaminal epidural corticosteroid injections and spinal cord infarction. Jt Bone Spine Rev Rhum. 2008;75:523–5.CrossRef
32.
go back to reference Baker R, Dreyfuss P, Mercer S, Bogduk N. Cervical transforaminal injection of corticosteroids into a radicular artery: a possible mechanism for spinal cord injury. Pain. 2003;103:211–5.CrossRef Baker R, Dreyfuss P, Mercer S, Bogduk N. Cervical transforaminal injection of corticosteroids into a radicular artery: a possible mechanism for spinal cord injury. Pain. 2003;103:211–5.CrossRef
33.
go back to reference Verrills P, Nowesenitz G, Barnard A. Penetration of a cervical radicular artery during a transforaminal epidural injection. Pain Med. 2010;11:229–31.CrossRef Verrills P, Nowesenitz G, Barnard A. Penetration of a cervical radicular artery during a transforaminal epidural injection. Pain Med. 2010;11:229–31.CrossRef
34.
go back to reference Ma DJ, Gilula LA, Riew KD. Complications of fluoroscopically guided extraforaminal cervical nerve blocks: an analysis of 1036 injections. J Bone Jt Surg. 2005;87:1025–30.CrossRef Ma DJ, Gilula LA, Riew KD. Complications of fluoroscopically guided extraforaminal cervical nerve blocks: an analysis of 1036 injections. J Bone Jt Surg. 2005;87:1025–30.CrossRef
35.
go back to reference Hong J, Jung S, Chang H. Whitacre needle reduces the incidence of intravascular uptake in lumbar transforaminal epidural steroid injections. Pain Physician. 2015;18:325–31.PubMed Hong J, Jung S, Chang H. Whitacre needle reduces the incidence of intravascular uptake in lumbar transforaminal epidural steroid injections. Pain Physician. 2015;18:325–31.PubMed
36.
go back to reference Wagner AL. CT fluoroscopic-guided cervical nerve root blocks. AJNR Am J Neuroradiol. 2005;26:43–4.PubMed Wagner AL. CT fluoroscopic-guided cervical nerve root blocks. AJNR Am J Neuroradiol. 2005;26:43–4.PubMed
37.
go back to reference Hoang JK, Apostol MA, Kranz PG, Kilani RK, Taylor JN, Gray L, et al. CT fluoroscopy-assisted cervical transforaminal steroid injection: tips, traps, and use of contrast material. Am J Roentgenol. 2010;195:888–94.CrossRef Hoang JK, Apostol MA, Kranz PG, Kilani RK, Taylor JN, Gray L, et al. CT fluoroscopy-assisted cervical transforaminal steroid injection: tips, traps, and use of contrast material. Am J Roentgenol. 2010;195:888–94.CrossRef
Metadata
Title
Comparison of three CT-guided epidural steroid injection approaches in 104 patients with cervical radicular pain: transforaminal anterolateral, posterolateral, and transfacet indirect
Authors
Sylvain Bise
Lionel Pesquer
Mathieu Feldis
Myriam Bou Antoun
Alain Silvestre
Arnaud Hocquelet
Benjamin Dallaudière
Publication date
01-12-2018
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 12/2018
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-018-3027-0

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