Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Skeletal Radiology
Published in: Skeletal Radiology 10/2018

01-10-2018 | Case Report

Primary thoracic giant cell tumor of bone sensitive to steroids

Authors: Huiliang Yang, Gi Hye Im, Gunnlaugur Petur Nielsen, Arvin Kheterpal, Joseph H. Schwab

Published in: Skeletal Radiology | Issue 10/2018

Login to get access

Abstract

Spinal giant cell tumor of bone (GCTB) is a rare benign, but locally aggressive, entity. We report the case of a 40-year-old man diagnosed with GCTB of the thoracic spine. The only symptom upon presentation was progressive back pain with pain radiating to the chest. Magnetic resonance imaging showed that the soft tissue mass extended posteriorly into the spinal canal, causing severe spinal cord compression. We initially treated this case with Decadron (Fresenius kabi, Bad Homburg vor der Hohe, Germany) for 1 week. This led to a reduction of tumor size and decompression of the spinal cord. To the best of our knowledge, there have been no prior reports of primary GCTB sensitive to steroid therapy within the existing literature.
Literature
1.
Kelly D, Mc Erlean S, Byrne D, Mahon PM, Mc Caffrey J. A case of thoracic giant cell tumor of bone and discussion of radiological features and current management practices. Radiol Case Rep. 2016;11:222–6.CrossRefPubMedPubMedCentral
2.
Boriani S, Bandiera S, Casadei R, et al. Giant cell tumor of the mobile spine: a review of 49 cases. Spine (Phila Pa 1976). 2012;37:E37–45.CrossRef
3.
Miller G, Bettelli G, Fabbri N, Capanna R. Curettage of giant cell tumor of bone. Introduction—material and methods. Chir Organi Mov. 1990;75:203.PubMed
4.
Larsson SE, Lorentzon R, Boquist L. Giant-cell tumor of bone. A demographic, clinical, and histopathological study of all cases recorded in the Swedish Cancer Registry for the years 1958 through 1968. J Bone Joint Surg Am. 1975;57:167–73.CrossRefPubMed
5.
Turcotte RE, Biagini R, Sim FH, Unni KK. Giant cell tumor of the spine and sacrum. Chir Organi Mov. 1990;75:104–7.PubMed
6.
Metkar U, Wardak Z, Katz DA, Lavelle WF. Giant cell tumor of a lumbar vertebra in a 7-year-old child: a case report. J Pediatr Orthop. 2012;32:e76–80.CrossRefPubMed
7.
Biermann JS, Chow W, Reed DR, et al. NCCN guidelines insights: bone cancer, version 2.2017. J Natl Compr Cancer Netw. 2017;15:155–67.CrossRef
8.
van der Heijden L, Dijkstra PDS, Blay JY, Gelderblom H. Giant cell tumour of bone in the denosumab era. Eur J Cancer. 2017;77:75–83.CrossRefPubMed
9.
Mavrogenis AF, Igoumenou VG, Megaloikonomos PD, Panagopoulos GN, Papagelopoulos PJ, Soucacos PN. Giant cell tumor of bone revisited. SICOT J. 2017;3:54.CrossRefPubMedPubMedCentral
10.
Rosenberg AE. WHO classification of soft tissue and bone, fourth edition: summary and commentary. Curr Opin Oncol. 2013;25:571–3.CrossRefPubMed
11.
Potter HG, Schneider R, Ghelman B, Healey JH, Lane JM. Multiple giant cell tumors and Paget disease of bone: radiographic and clinical correlations. Radiology. 1991;180:261–4.CrossRefPubMed
12.
Lewis JJ, Healey JH, Huvos AG, Burt M. Benign giant-cell tumor of bone with metastasis to mediastinal lymph nodes. A case report of resection facilitated with use of steroids. J Bone Joint Surg Am. 1996;78:106–10.CrossRefPubMed
13.
De Chiara A, Apice G, Fazioli F, Silvestro P, Carone G, Manco A. Multicentric giant cell tumor with viral-like inclusions associated with Paget's disease of bone: a case treated by steroid therapy. Oncol Rep. 1998;5:317–20.PubMed
14.
Iacono F, Ruffo A, Di Lauro G, Romis L, Illiano E, Prezioso D. A case of giant cell tumor of the hipbone invading the bladder. Urologia. 2011;78:142–4.CrossRefPubMed
15.
Gebhart M, Vandeweyer E, Nemec E. Paget's disease of bone complicated by giant cell tumor. Clin Orthop Relat Res. 1998:187–93.
16.
Jacobs TP, Michelsen J, Polay JS, D'Adamo AC, Canfield RE. Giant cell tumor in Paget's disease of bone: familial and geographic clustering. Cancer. 1979;44:742–7.CrossRefPubMed
17.
Kumar A, Weber MH, Gokaslan Z, et al. Metastatic spinal cord compression and steroid treatment: a systematic review. Clin Spine Surg. 2017;30:156–63.CrossRefPubMed
18.
Peacock ZS, Schwab JH, Faquin WC, et al. Genetic analysis of giant cell lesions of the maxillofacial and axial/appendicular skeletons. J Oral Maxillofac Surg. 2017;75:298–308.CrossRefPubMed
19.
Peacock ZS, Resnick CM, Susarla SM, et al. Do histologic criteria predict biologic behavior of giant cell lesions? J Oral Maxillofac Surg. 2012;70:2573–80.CrossRefPubMed
20.
Resnick CM, Margolis J, Susarla SM, et al. Maxillofacial and axial/appendicular giant cell lesions: unique tumors or variants of the same disease?—a comparison of phenotypic, clinical, and radiographic characteristics. J Oral Maxillofac Surg. 2010;68:130–7.CrossRefPubMed
21.
El Hadidi YN, Ghanem AA, Helmy I. Injection of steroids intralesional in central giant cell granuloma cases (giant cell tumor): is it free of systemic complications or not? A case report. Int J Surg Case Rep. 2015;8C:166–70.CrossRefPubMed
22.
Comert E, Turanli M, Ulu S. Oral and intralesional steroid therapy in giant cell granuloma. Acta Otolaryngol. 2006;126:664–6.CrossRefPubMed
23.
da Silva NG, Carreira AS, Pedreira EN, Tuji FM, Ortega KL, de Jesus Viana Pinheiro J. Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections. Head Face Med. 2012;8:23.CrossRefPubMed
24.
Carlos R, Sedano HO. Intralesional corticosteroids as an alternative treatment for central giant cell granuloma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;93:161–6.CrossRefPubMed
25.
Nogueira RL, Teixeira RC, Cavalcante RB, Ribeiro RA, Rabenhosrt SH. Intralesional injection of triamcinolone hexacetonide as an alternative treatment for central giant-cell granuloma in 21 cases. Int J Oral Maxillofac Surg. 2010;39:1204–10.CrossRefPubMed
26.
27.
Martin C, McCarthy EF. Giant cell tumor of the sacrum and spine: series of 23 cases and a review of the literature. Iowa Orthop J. 2010;30:69–75.PubMedPubMedCentral
28.
Campanacci M, Baldini N, Boriani S, Sudanese A. Giant-cell tumor of bone. J Bone Joint Surg Am. 1987;69:106–14.CrossRefPubMed
29.
Dolanmaz D, Esen A, Mihmanli A, Isik K. Management of central giant cell granuloma of the jaws with intralesional steroid injection and review of the literature. Oral Maxillofac Surg. 2016;20:203–9.CrossRefPubMed
Metadata
Title
Primary thoracic giant cell tumor of bone sensitive to steroids
Authors
Huiliang Yang
Gi Hye Im
Gunnlaugur Petur Nielsen
Arvin Kheterpal
Joseph H. Schwab
Publication date
01-10-2018
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 10/2018
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-018-2911-y

Other articles of this Issue 10/2018

Skeletal Radiology 10/2018 Go to the issue

Case Report

Synchronous bilateral lipoma arborescens of bicipitoradial bursa—a rare entity

Scientific Article

Quantification of fat content in lipid-rich myxoid liposarcomas with MRI: a single-center experience with survival analysis

Test Yourself: Answer

Bilateral painful foot masses

Browser's Notes

Browser’s notes

Review Article

Culture yield of repeat percutaneous image-guided biopsy after a negative initial biopsy in suspected spondylodiscitis: a systematic review

Case Report

Osteoid osteoma of the scaphoid bone associated with flexor carpi radialis calcific tendinitis and treated with CT-guided RF ablation