Skip to main content
Top
Published in: Skeletal Radiology 7/2014

01-07-2014 | Case Report

Diffuse skeletal muscle metastases from sacral chordoma

Authors: Kathleen Carey, Joseph Bestic, Steven Attia, Cherise Cortese, Manoj Jain

Published in: Skeletal Radiology | Issue 7/2014

Login to get access

Abstract

Chordomas are rare, slow-growing tumors arising from cellular remnants of the notochord. They account for 1–4 % of primary malignant bone tumors and usually occur in the axial skeleton, most commonly the sacrum. Although typically locally recurrent, chordoma metastasis rates as high as 10–42 % have been reported. While spread to multiple organ systems has been documented, metastatic disease to skeletal muscle is extremely rare. We present a case of extensive, multifocal skeletal muscle metastases developing in the setting of recurrent sacral chordoma. Our literature search found only one additional case of metastatic chordoma to a single skeletal muscle.
Literature
1.
go back to reference McPherson CM, Suki D, McCutcheon IE, Gokaslan ZL, Rhines LD, Mendel E. Metastatic disease from spinal chordoma: a 10-year experience. J Neurosurg Spine. 2006;5(4):277–80.PubMedCrossRef McPherson CM, Suki D, McCutcheon IE, Gokaslan ZL, Rhines LD, Mendel E. Metastatic disease from spinal chordoma: a 10-year experience. J Neurosurg Spine. 2006;5(4):277–80.PubMedCrossRef
2.
go back to reference Chambers PW, Schwinn CP. Chordoma. A clinicopathologic study of metastasis Am J Clin Pathol. 1979;72(5):765–76.PubMed Chambers PW, Schwinn CP. Chordoma. A clinicopathologic study of metastasis Am J Clin Pathol. 1979;72(5):765–76.PubMed
3.
go back to reference Fearon C, Fabre A, Heffernan EJ, Skehan SJ, Swan N, Keane MP, et al. Metastatic chordoma detected by endobronchial ultrasound-guided transbronchial needle aspiration. J Thorac Dis. 2013;5(1):90–3.PubMedCentralPubMed Fearon C, Fabre A, Heffernan EJ, Skehan SJ, Swan N, Keane MP, et al. Metastatic chordoma detected by endobronchial ultrasound-guided transbronchial needle aspiration. J Thorac Dis. 2013;5(1):90–3.PubMedCentralPubMed
5.
go back to reference Stacchiotti S, Longhi A, Ferraresi V, Grignani G, Comandone A, Stupp R, et al. Phase II study of imatinib in advanced chordoma. J Clin Oncol. 2012;30(9):914–20.PubMedCrossRef Stacchiotti S, Longhi A, Ferraresi V, Grignani G, Comandone A, Stupp R, et al. Phase II study of imatinib in advanced chordoma. J Clin Oncol. 2012;30(9):914–20.PubMedCrossRef
6.
go back to reference Farsad K, Kattapuram SV, Sacknoff R, Ono J, Nielsen GP. Sacral chordoma. Radiographics. 2009;29(5):1525–30.PubMedCrossRef Farsad K, Kattapuram SV, Sacknoff R, Ono J, Nielsen GP. Sacral chordoma. Radiographics. 2009;29(5):1525–30.PubMedCrossRef
7.
go back to reference Diel J, Ortiz O, Losada RA, Price DB, Hayt MW, Katz DS. The sacrum: pathologic spectrum, multimodality imaging, and subspecialty approach. Radiographics. 2001;21(1):83-104.PubMedCrossRef Diel J, Ortiz O, Losada RA, Price DB, Hayt MW, Katz DS. The sacrum: pathologic spectrum, multimodality imaging, and subspecialty approach. Radiographics. 2001;21(1):83-104.PubMedCrossRef
9.
go back to reference Bethke KP, Neifeld JP, Lawrence Jr W. Diagnosis and management of sacrococcygeal chordoma. J Surg Oncol. 1991;48(4):232–8.PubMedCrossRef Bethke KP, Neifeld JP, Lawrence Jr W. Diagnosis and management of sacrococcygeal chordoma. J Surg Oncol. 1991;48(4):232–8.PubMedCrossRef
10.
go back to reference Mukherjee D, Chaichana KL, Gokaslan ZL, Aaronson O, Cheng JS, McGirt MJ. Survival of patients with malignant primary osseous spinal neoplasms: results from the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2003. J Neurosurg Spine. 2011;14(2):143–50.PubMedCrossRef Mukherjee D, Chaichana KL, Gokaslan ZL, Aaronson O, Cheng JS, McGirt MJ. Survival of patients with malignant primary osseous spinal neoplasms: results from the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2003. J Neurosurg Spine. 2011;14(2):143–50.PubMedCrossRef
11.
go back to reference Bergh P, Kindblom LG, Gunterberg B, Remotti F, Ryd W, Meis-Kindblom JM. Prognostic factors in chordoma of the sacrum and mobile spine: a study of 39 patients. Cancer. 2000;88(9):2122–34.PubMedCrossRef Bergh P, Kindblom LG, Gunterberg B, Remotti F, Ryd W, Meis-Kindblom JM. Prognostic factors in chordoma of the sacrum and mobile spine: a study of 39 patients. Cancer. 2000;88(9):2122–34.PubMedCrossRef
12.
go back to reference Kilgore S, Prayson RA. Apoptotic and proliferative markers in chordomas: a study of 26 tumors. Ann Diagn Pathol. 2002;6(4):222–8.PubMedCrossRef Kilgore S, Prayson RA. Apoptotic and proliferative markers in chordomas: a study of 26 tumors. Ann Diagn Pathol. 2002;6(4):222–8.PubMedCrossRef
13.
go back to reference Mukherjee D, Chaichana KL, Parker SL, Gokaslan ZL, McGirt MJ. Association of surgical resection and survival in patients with malignant primary osseous spinal neoplasms from the Surveillance, Epidemiology, and End Results (SEER) database. Eur Spine J. 2013;22(6):1375–82.PubMedCrossRef Mukherjee D, Chaichana KL, Parker SL, Gokaslan ZL, McGirt MJ. Association of surgical resection and survival in patients with malignant primary osseous spinal neoplasms from the Surveillance, Epidemiology, and End Results (SEER) database. Eur Spine J. 2013;22(6):1375–82.PubMedCrossRef
14.
go back to reference Surov A, Hainz M, Holzhausen HJ, Arnold D, Katzer M, Schmidt J, et al. Skeletal muscle metastases: primary tumours, prevalence, and radiological features. Eur Radiol. 2010;20(3):649–58.PubMedCrossRef Surov A, Hainz M, Holzhausen HJ, Arnold D, Katzer M, Schmidt J, et al. Skeletal muscle metastases: primary tumours, prevalence, and radiological features. Eur Radiol. 2010;20(3):649–58.PubMedCrossRef
15.
go back to reference Bar-Yehuda S, Barer F, Volfsson L, Fishman P. Resistance of muscle to tumor metastases: a role for A3 adenosine receptor agonists. Neoplasia. 2001;3:125–31.PubMedCentralPubMedCrossRef Bar-Yehuda S, Barer F, Volfsson L, Fishman P. Resistance of muscle to tumor metastases: a role for A3 adenosine receptor agonists. Neoplasia. 2001;3:125–31.PubMedCentralPubMedCrossRef
16.
go back to reference Herring Jr CL, Harrelson JM, Scully SP. Metastatic carcinoma to skeletal muscle. A report of 15 patients. Clin Orthop Relat Res. 1998;355:272–81.PubMedCrossRef Herring Jr CL, Harrelson JM, Scully SP. Metastatic carcinoma to skeletal muscle. A report of 15 patients. Clin Orthop Relat Res. 1998;355:272–81.PubMedCrossRef
17.
go back to reference Park L, Delaney TF, Liebsch NJ, Hornicek FJ, Goldberg S, Mankin H, et al. Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor. Int J Radiat Oncol Biol Phys. 2006;65(5):1514–21.PubMedCrossRef Park L, Delaney TF, Liebsch NJ, Hornicek FJ, Goldberg S, Mankin H, et al. Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor. Int J Radiat Oncol Biol Phys. 2006;65(5):1514–21.PubMedCrossRef
18.
go back to reference Fourney DR, Rhines LD, Hentschel SJ, Skibber JM, Wolinsky JP, Weber KL, et al. En bloc resection of primary sacral tumors: classification of surgical approaches and outcome. J Neurosurg Spine. 2005;3:111–22.PubMedCrossRef Fourney DR, Rhines LD, Hentschel SJ, Skibber JM, Wolinsky JP, Weber KL, et al. En bloc resection of primary sacral tumors: classification of surgical approaches and outcome. J Neurosurg Spine. 2005;3:111–22.PubMedCrossRef
Metadata
Title
Diffuse skeletal muscle metastases from sacral chordoma
Authors
Kathleen Carey
Joseph Bestic
Steven Attia
Cherise Cortese
Manoj Jain
Publication date
01-07-2014
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 7/2014
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-013-1794-1

Other articles of this Issue 7/2014

Skeletal Radiology 7/2014 Go to the issue

Browser's Notes

Browser’s notes