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01-06-2012 | Scientific Article

Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging

Authors: Christian Buchbender, Axel Scherer, Patric Kröpil, Birthe Körbl, Michael Quentin, Dorothea Ch. Reichelt, Rotem S. Lanzman, Christian Mathys, Dirk Blondin, Bernd Bittersohl, Christoph Zilkens, Matthias Hofer, Hans-Jörg Wittsack, Matthias Schneider, Gerald Antoch, Benedikt Ostendorf, Falk Miese

Published in: Skeletal Radiology | Issue 6/2012

Abstract

Purpose

To prospectively evaluate four non-invasive markers of cartilage quality—T2* mapping, native T1 mapping, dGEMRIC and ΔR1—in healthy volunteers and rheumatoid arthritis (RA) patients.

Materials and methods

Cartilage of metacarpophalangeal (MCP) joints II were imaged in 28 consecutive subjects: 12 healthy volunteers [9 women, mean (SD) age 52.67 (9.75) years, range 30–66] and 16 RA patients with MCP II involvement [12 women, mean (SD) age 58.06 (12.88) years, range 35–76]. Sagittal T2* mapping was performed with a multi-echo gradient-echo on a 3 T MRI scanner. For T1 mapping the dual flip angle method was applied prior to native T1 mapping and 40 min after gadolinium application (delayed gadolinium-enhanced MRI of cartilage, dGEMRIC, T1_Gd). The difference in the longitudinal relaxation rate induced by gadolinium (ΔR1) was calculated. The area under the receiver operating characteristic curve (AROC) was used to test for differentiation of RA patients from healthy volunteers.

Results

dGEMRIC (AUC 0.81) and ΔR1 (AUC 0.75) significantly differentiated RA patients from controls. T2* mapping (AUC 0.66) and native T1 mapping (AUC 0.66) were not significantly different in RA patients compared to controls.

Conclusions

The data support the use of dGEMRIC for the assessment of MCP joint cartilage quality in RA. T2* and native T1 mapping are of low diagnostic value. Pre-contrast T1 mapping for the calculation of ΔR1 does not increase the diagnostic value of dGEMRIC.

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Title: Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging
Authors: Christian Buchbender
Axel Scherer
Patric Kröpil
Birthe Körbl
Michael Quentin
Dorothea Ch. Reichelt
Rotem S. Lanzman
Christian Mathys
Dirk Blondin
Bernd Bittersohl
Christoph Zilkens
Matthias Hofer
Hans-Jörg Wittsack
Matthias Schneider
Gerald Antoch
Benedikt Ostendorf
Falk Miese
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: Skeletal Radiology / Issue 6/2012
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI: https://doi.org/10.1007/s00256-011-1276-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging

Abstract

Purpose

Materials and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusions

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