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01-05-2017 | Original Article

Subjective and objective image differences in pediatric computed tomography cardiac angiography using lower iodine concentration

Authors: Jae-Yeon Hwang, Ki Seok Choo, Yoon Young Choi, Jin Hyeok Kim, Hwaseong Ryu, Junhee Han, Yong-Woo Kim, Ung Bae Jeon, Kyung Jin Nam

Published in: Pediatric Radiology | Issue 6/2017

Abstract

Background

Several recent studies showed the optimal contrast enhancement with a low-concentration and iso-osmolar contrast media in both adult and pediatric patients. However, low contrast media concentrations are not routinely used due to concerns of suboptimal enhancement of cardiac structures and small vessels.

Objective

To evaluate the feasibility of using iso-osmolar contrast media containing a low iodine dose for CT cardiac angiography at 80 kilovolts (kVp) in neonates and infants.

Materials and methods

The iodixanol 270 group consisted of 79 CT scans and the iopromide 370 group of 62 CT scans in patients ≤1 year old. Objective measurement of the contrast enhancement was analyzed and contrast-to-noise ratios of the ascending aorta and left ventricle were calculated. Regarding subjective measurement, a four-point scale system was devised to evaluate degrees of contrast enhancement, image noise, motion artifact and overall image quality of each image set. Reader performance for correctly differentiating iodixanol 270 and iopromide 370 by visual assessment was evaluated.

Results

Group objective and subjective measurements were nonsignificantly different. Overall sensitivity, specificity and diagnostic accuracy for correctly differentiating iodixanol 270 and iopromide 370 by visual assessment were 42.8%, 59%, and 50%, respectively.

Conclusion

The application of iodixanol 270 achieved optimal enhancement for performing pediatric cardiac CT angiography at 80 kVp in neonates and infants. Objective measurements of contrast enhancement and subjective image quality assessments were not statistically different in the iodixanol 270 and iopromide 370 groups.

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Title: Subjective and objective image differences in pediatric computed tomography cardiac angiography using lower iodine concentration
Authors: Jae-Yeon Hwang
Ki Seok Choo
Yoon Young Choi
Jin Hyeok Kim
Hwaseong Ryu
Junhee Han
Yong-Woo Kim
Ung Bae Jeon
Kyung Jin Nam
Publication date: 01-05-2017
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Radiology / Issue 6/2017
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-017-3795-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Subjective and objective image differences in pediatric computed tomography cardiac angiography using lower iodine concentration

Abstract

Background

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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