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01-05-2016 | Original Article

Sclerotic bone lesions at abdominal magnetic resonance imaging in children with tuberous sclerosis complex

Authors: Susana Boronat, Ignasi Barber, Vivek Pargaonkar, Joshua Chang, Elizabeth A. Thiele

Published in: Pediatric Radiology | Issue 5/2016

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Abstract

Background

Sclerotic bone lesions are often seen on chest CT in adults with tuberous sclerosis complex.

Objective

To characterize bone lesions at abdominal MRI in children with tuberous sclerosis complex.

Materials and methods

This retrospective review included 70 children with tuberous sclerosis complex who had undergone abdominal MRI for renal imaging. An additional longitudinal study was performed in 50 children who had had two or more MRI scans. Abdominal CT (eight children) and radiographs (three children) were reviewed and compared with MRI.

Results

A total of 173 sclerotic bone lesions were detected in 51/70 children (73%; 95% confidence interval: 0.61–0.82) chiefly affecting vertebral pedicles. New lesions appeared in 20 children and growth of previous sclerotic bone lesions was documented in 14 children. Sclerotic bone lesions were more frequent in girls and in children with more extensive renal involvement.

Conclusion

Sclerotic bone lesions are commonly detected by abdominal MRI in children with tuberous sclerosis complex. They usually affect posterior vertebral elements and their number and size increase with age. As current recommendations for tuberous sclerosis complex surveillance include renal MR performed in childhood, recognition of these lesions is useful.

1.

Crino PB, Nathanson KL, Henske EP (2006) The tuberous sclerosis complex. N Engl J Med 355:1345–1356CrossRefPubMed

2.

Roach ES, Gomez MR, Northrup H (1998) Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria. J Child Neurol 13:624–628CrossRefPubMed

3.

Northrup H, Krueger DA, International Tuberous Sclerosis Complex Consensus Group (2013) Tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012 international tuberous sclerosis complex consensus conference. Pediatr Neurol 49:243–254CrossRefPubMedPubMedCentral

4.

Avila NA, Dwyer AJ, Rabel A et al (2010) CT of sclerotic bone lesions: imaging features differentiating tuberous sclerosis complex with lymphangioleiomyomatosis from sporadic lymphangioleiomymatosis. Radiology 254:851–857CrossRefPubMedPubMedCentral

5.

Stosic-Opincal T, Peric V, Lilic G et al (2005) Spine MRI findings in a patient with tuberous sclerosis: a case report--part II. Spine 30:992–993CrossRefPubMed

6.

Krueger DA, Northrup H, International Tuberous Sclerosis Complex Consensus Group (2013) Tuberous sclerosis complex surveillance and management: recommendations of the 2012 international tuberous sclerosis complex consensus conference. Pediatr Neurol 49:255–265CrossRefPubMedPubMedCentral

7.

Evans JC, Curtis J (2000) The radiological appearances of tuberous sclerosis. Br J Radiol 73:91–98CrossRefPubMed

8.

Umeoka S, Koyama T, Miki Y et al (2008) Pictorial review of tuberous sclerosis in various organs. Radiographics 28:e32CrossRefPubMed

9.

Jonard P, Lonneux M, Boland B et al (2001) Tc-99m HDP bone scan showing bone changes in a case of tuberous sclerosis or Bourneville’s disease. Clin Nucl Med 26:50–52CrossRefPubMed

10.

Komar NN, Gabrielsen TO, Holt JF (1967) Roentgenographic appearance of lumbosacral spine and pelvis in tuberous sclerosis. Radiology 89:701–705CrossRefPubMed

11.

Song L, Zhang Y, Zhang W (2013) Bone scintigraphy may help differentiate bone sclerotic lesions from osteoblastic metastases in tuberous sclerosis patients with concomitant pulmonary adenocarcinoma. Clin Imaging 37:382–385CrossRefPubMed

12.

Holt JF, Dickerson WW (1952) The osseous lesions of tuberous sclerosis. Radiology 58:1–8CrossRefPubMed

13.

Boronat S, Shaaya E, Doherty C et al (2014) Tuberous sclerosis complex without tubers and subependymal nodules: a phenotype-genotype study. Clin Genet 86:149–154CrossRefPubMed

14.

Carsillo T, Astrinidis A, Henske EP (2000) Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci U S A 97:6085–6090CrossRefPubMedPubMedCentral

15.

Fang F, Sun S, Wang L et al (2015) Neural crest-specific TSC1 deletion in mice leads to sclerotic craniofacial bone lesion. J Bone Miner Res. doi:10.1002/jbmr.2447 PubMedPubMedCentral

16.

Pui MH, Kong HL, Choo HF (1996) Bone changes in tuberous sclerosis mimicking metastases. Australas Radiol 40:77–79CrossRefPubMed

17.

Rodallec MH, Feydy A, Larousserie F et al (2008) Diagnostic imaging of solitary tumors of the spine: what to do and say. Radiographics 28:1019–1041CrossRefPubMed

18.

Onitsuka H (1977) Roentgenologic aspects of bone islands. Radiology 123:607–612CrossRefPubMed

19.

Bracken J, Nandurkar D, Radhakrishnan K et al (2013) Normal paediatric bone marrow: magnetic resonance imaging appearances from birth to 5 years. J Med Imaging Radiat Oncol 57:283–291CrossRefPubMed

Title: Sclerotic bone lesions at abdominal magnetic resonance imaging in children with tuberous sclerosis complex
Authors: Susana Boronat
Ignasi Barber
Vivek Pargaonkar
Joshua Chang
Elizabeth A. Thiele
Publication date: 01-05-2016
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Radiology / Issue 5/2016
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-016-3549-3

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