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01-08-2013 | Original Article

Dynamic contrast-enhanced MRI improves accuracy for detecting focal splenic involvement in children and adolescents with Hodgkin disease

Authors: Shonit Punwani, King Kenneth Cheung, Nicholas Skipper, Nichola Bell, Alan Bainbridge, Stuart A. Taylor, Ashley M. Groves, Sharon F. Hain, Simona Ben-Haim, Ananth Shankar, Stephen Daw, Steve Halligan, Paul D. Humphries

Published in: Pediatric Radiology | Issue 8/2013

Abstract

Background

Accurate assessment of splenic disease is important for staging Hodgkin lymphoma.

Objective

The purpose of this study was to assess T2-weighted imaging with and without dynamic contrast-enhanced (DCE) MRI for evaluation of splenic Hodgkin disease.

Materials and methods

Thirty-one children with Hodgkin lymphoma underwent whole-body T2-weighted MRI with supplementary DCE splenic imaging, and whole-body PET-CT before and following chemotherapy. Two experienced nuclear medicine physicians derived a PET-CT reference standard for splenic disease, augmented by follow-up imaging. Unaware of the PET-CT, two experienced radiologists independently evaluated MRI exercising a locked sequential read paradigm (T2-weighted then DCE review) and recorded the presence/absence of splenic disease at each stage. Performance of each radiologist was determined prior to and following review of DCE-MRI. Incorrect MRI findings were ascribed to reader (lesion present on MRI but missed by reader) or technical (lesion not present on MRI) error.

Results

Seven children had splenic disease. Sensitivity/specificity of both radiologists for the detection of splenic involvement using T2-weighted images alone was 57%/100% and increased to 100%/100% with DCE-MRI. There were three instances of technical error on T2-weighted imaging; all lesions were visible on DCE-MRI.

Conclusions

T2-weighted imaging when complemented by DCE-MRI imaging may improve evaluation of Hodgkin disease splenic involvement.

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Title: Dynamic contrast-enhanced MRI improves accuracy for detecting focal splenic involvement in children and adolescents with Hodgkin disease
Authors: Shonit Punwani
King Kenneth Cheung
Nicholas Skipper
Nichola Bell
Alan Bainbridge
Stuart A. Taylor
Ashley M. Groves
Sharon F. Hain
Simona Ben-Haim
Ananth Shankar
Stephen Daw
Steve Halligan
Paul D. Humphries
Publication date: 01-08-2013
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Radiology / Issue 8/2013
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-012-2616-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Dynamic contrast-enhanced MRI improves accuracy for detecting focal splenic involvement in children and adolescents with Hodgkin disease

Abstract

Background

Objective

Materials and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusions

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