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Pediatric Radiology
Published in: Pediatric Radiology 10/2010

01-10-2010 | Case Report

Hepatocellular carcinoma and regenerating nodule in a 3-year-old child with Alagille syndrome

Authors: Sylvia C. Wetli, Eva S. Gralla, Susanne Schibli, Enno Stranzinger

Published in: Pediatric Radiology | Issue 10/2010

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Abstract

In Alagille syndrome, routine follow-up imaging of the liver plays an important role in detecting early parenchymal changes and to evaluate portal hypertension. Modern contrast-enhanced imaging methods not only allow early detection of focal liver lesions, but also enable further characterization of their nature and guide biopsy procedures. We present the US and MR imaging findings of hepatocellular carcinoma and a regenerating nodule in a 3-year-old child with Alagille syndrome.
Literature
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Lowe LH, Schlesinger AE (2008) Congenital abnormalities, Alagille syndrome. In: Slovis TL et al (eds) Caffey’s pediatric diagnostic imaging, 11th edn. Mosby, Philadelphia, p 1861
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Wegmann W, Evison J, Schaub N et al (1996) Liver cell carcinoma as a late complication of Alagille syndrome (arterio-hepatic dysplasia). Leber Magen Darm 26:157–158, 161-153PubMed
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Bhadri VA, Stormon MO, Arbuckle S et al (2005) Hepatocellular carcinoma in children with Alagille syndrome. J Pediatr Gastroenterol Nutr 41:676–678CrossRefPubMed
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Tajima T, Honda H, Yanaga K et al (2001) Hepatic nodular hyperplasia in a boy with Alagille syndrome: CT and MR appearances. Pediatr Radiol 31:584–588CrossRefPubMed
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Kim B, Park SH, Yang HR et al (2005) Hepatocellular carcinoma occurring in alagille syndrome. Pathol Res Pract 201:55–60CrossRefPubMed
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Blane CE, Jongeward RH Jr, Silver TM (1983) Sonographic features of hepatocellular disease in neonates and infants. AJR 141:1313–1316PubMed
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Choi SH, Lee JM, Yu NC et al (2008) Hepatocellular carcinoma in liver transplantation candidates: detection with gadobenate dimeglumine-enhanced MRI. AJR 191:529–536CrossRefPubMed
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Strobel D, Seitz K, Blank W et al (2009) Tumor-specific vascularization pattern of liver metastasis, hepatocellular carcinoma, hemangioma and focal nodular hyperplasia in the differential diagnosis of 1,349 liver lesions in contrast-enhanced ultrasound (CEUS). Ultraschall Med 30:376–382CrossRefPubMed
Metadata
Title
Hepatocellular carcinoma and regenerating nodule in a 3-year-old child with Alagille syndrome
Authors
Sylvia C. Wetli
Eva S. Gralla
Susanne Schibli
Enno Stranzinger
Publication date
01-10-2010
Publisher
Springer-Verlag
Published in
Pediatric Radiology / Issue 10/2010
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-010-1784-6

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