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Published in: Pediatric Radiology 8/2009

01-08-2009 | Case Report

Abnormal fetal cerebral laminar organization in cobblestone complex as seen on post-mortem MRI and DTI

Authors: Elysa Widjaja, Sasikhan Geibprasert, Susan Blaser, Tammy Rayner, Patrick Shannon

Published in: Pediatric Radiology | Issue 8/2009

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Abstract

We report a unique case of cobblestone complex using post-mortem MR and diffusion tensor imaging to assess the laminar organization of the fetal cerebrum. The imaging findings were correlated with autopsy findings. Abnormal cortical development in cobblestone complex resulted in disruption of normal laminar organization of the fetal brain, which was seen as interruption and nodularity of the high-signal T1 cortical band with increased anisotropy and medium diffusivity extending beyond the cortical band into the cerebral mantle on post-mortem MR and diffusion tensor imaging.
Literature
1.
go back to reference Barkovich AJ (2005) Pediatric neuroimaging. Lippincott Williams and Wilkins, Philadelphia Barkovich AJ (2005) Pediatric neuroimaging. Lippincott Williams and Wilkins, Philadelphia
2.
go back to reference Longman C, Mercuri E, Cowan F et al (2004) Antenatal and postnatal brain magnetic resonance imaging in muscle-eye-brain disease. Arch Neurol 61:1301–1306PubMedCrossRef Longman C, Mercuri E, Cowan F et al (2004) Antenatal and postnatal brain magnetic resonance imaging in muscle-eye-brain disease. Arch Neurol 61:1301–1306PubMedCrossRef
3.
go back to reference Huppert BJ, Brandt KR, Ramin KD et al (1999) Single-shot fast spin-echo MR imaging of the fetus: a pictorial essay. Radiographics 19 Spec No:S215–S227PubMed Huppert BJ, Brandt KR, Ramin KD et al (1999) Single-shot fast spin-echo MR imaging of the fetus: a pictorial essay. Radiographics 19 Spec No:S215–S227PubMed
4.
go back to reference Maas LC, Mukherjee P, Carballido-Gamio J et al (2004) Early laminar organization of the human cerebrum demonstrated with diffusion tensor imaging in extremely premature infants. Neuroimage 22:1134–1140PubMedCrossRef Maas LC, Mukherjee P, Carballido-Gamio J et al (2004) Early laminar organization of the human cerebrum demonstrated with diffusion tensor imaging in extremely premature infants. Neuroimage 22:1134–1140PubMedCrossRef
5.
go back to reference Chong BW, Babcook CJ, Salamat MS et al (1996) A magnetic resonance template for normal neuronal migration in the fetus. Neurosurgery 39:110–116PubMedCrossRef Chong BW, Babcook CJ, Salamat MS et al (1996) A magnetic resonance template for normal neuronal migration in the fetus. Neurosurgery 39:110–116PubMedCrossRef
6.
go back to reference Kostovic I, Judas M, Rados M et al (2002) Laminar organization of the human fetal cerebrum revealed by histochemical markers and magnetic resonance imaging. Cereb Cortex 12:536–544PubMedCrossRef Kostovic I, Judas M, Rados M et al (2002) Laminar organization of the human fetal cerebrum revealed by histochemical markers and magnetic resonance imaging. Cereb Cortex 12:536–544PubMedCrossRef
7.
go back to reference Brisse H, Fallet C, Sebag G et al (1997) Supratentorial parenchyma in the developing fetal brain: in vitro MR study with histologic comparison. AJNR 18:1491–1497PubMed Brisse H, Fallet C, Sebag G et al (1997) Supratentorial parenchyma in the developing fetal brain: in vitro MR study with histologic comparison. AJNR 18:1491–1497PubMed
8.
go back to reference McKinstry RC, Mathur A, Miller JH et al (2002) Radial organization of developing preterm human cerebral cortex revealed by non-invasive water diffusion anisotropy MRI. Cereb Cortex 12:1237–1243PubMedCrossRef McKinstry RC, Mathur A, Miller JH et al (2002) Radial organization of developing preterm human cerebral cortex revealed by non-invasive water diffusion anisotropy MRI. Cereb Cortex 12:1237–1243PubMedCrossRef
Metadata
Title
Abnormal fetal cerebral laminar organization in cobblestone complex as seen on post-mortem MRI and DTI
Authors
Elysa Widjaja
Sasikhan Geibprasert
Susan Blaser
Tammy Rayner
Patrick Shannon
Publication date
01-08-2009
Publisher
Springer-Verlag
Published in
Pediatric Radiology / Issue 8/2009
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-009-1255-0

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