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01-07-2009 | Clinical Image

Hyperintense vessel sign: isolated cortical venous thrombosis after l-asparaginase therapy

Authors: Krishnamoorthy Thamburaj, Arabinda Choudhary

Published in: Pediatric Radiology | Issue 7/2009

Excerpt

A 14-year-old girl with T-cell acute lymphatic leukemia presented with a 1-week history of headache and left arm and leg numbness after initiation of induction therapy including l-asparaginase. MRI of the brain showed isolated cortical venous thrombosis with hyperintensity on T1-weighted and diffusion-weighted (Fig. 1) images with hemorrhagic venous infarct (Fig. 1a, star). The dural venous sinuses were patent (arrow). She mainly received antiedema measures because the entity was not initially recognized. By the time the cortical vein thrombosis was identified, her neurological status had improved. …

Erbetta A, Salmaggi A, Sghirlanzoni A et al (2008) Clinical and radiological features of brain neurotoxicity caused by antitumor and immunosuppressant treatments. Neurol Sci 29:131–137PubMedCrossRef

Kieslich M, Porto L, Lanfermann H et al (2003) Cerebrovascular complications of L-asparaginase in the therapy of acute lymphoblastic leukemia. J Pediatr Hematol Oncol 25:484–487PubMedCrossRef

Title: Hyperintense vessel sign: isolated cortical venous thrombosis after l-asparaginase therapy
Authors: Krishnamoorthy Thamburaj
Arabinda Choudhary
Publication date: 01-07-2009
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 7/2009
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-009-1171-3

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Hyperintense vessel sign: isolated cortical venous thrombosis after l-asparaginase therapy

Excerpt

Keynote webinar | Spotlight on medication adherence

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