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Pediatric Radiology

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01-12-2008 | Original Article

Diffusion-weighted and dynamic contrast-enhanced imaging as markers of clinical behavior in children with optic pathway glioma

Authors: Sarah C. Jost, Joseph W. Ackerman, Joel R. Garbow, Linda P. Manwaring, David H. Gutmann, Robert C. McKinstry

Published in: Pediatric Radiology | Issue 12/2008

Abstract

Background

Optic pathway gliomas (OPGs) are common pediatric brain tumors that pose significant clinical challenges with regard to predicting which tumors are likely to become symptomatic and require treatment. These tumors can arise sporadically or in the context of the inherited cancer predisposition syndrome neurofibromatosis type 1 (NF1). Few studies have suggested biological or imaging markers that predict the clinical course of this disease.

Objective

In this cross-sectional study, we hypothesized that the clinical behavior of OPGs in children can be differentiated by diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI.

Materials and methods

A total of 27 children with OPG were studied using DW and DCE MRI protocols. Diffusivity and permeability were calculated and correlated with the clinical behavior the OPG.

Results

Mean diffusivity values of 1.39 μm²/ms and mean permeability values of 2.10 ml/min per 100 cm³ of tissue were measured. Clinically aggressive OPGs had significantly higher mean permeability values (P = 0.05) than clinically stable tumors. In addition, there was a strong correlation between clinical aggressiveness and the absence of NF1 (P < 0.01).

Conclusion

These results suggest that DCE MRI might be a useful biomarker for clinically aggressive OPG, which should be confirmed in larger prospective longitudinal studies.

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Title: Diffusion-weighted and dynamic contrast-enhanced imaging as markers of clinical behavior in children with optic pathway glioma
Authors: Sarah C. Jost
Joseph W. Ackerman
Joel R. Garbow
Linda P. Manwaring
David H. Gutmann
Robert C. McKinstry
Publication date: 01-12-2008
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 12/2008
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-008-1003-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Diffusion-weighted and dynamic contrast-enhanced imaging as markers of clinical behavior in children with optic pathway glioma

Abstract

Background

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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