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01-07-2008 | Case Report

Biliary wall calcification in Langerhans cell histiocytosis: report of two cases

Authors: Settimo Caruso, Roberto Miraglia, Luigi Maruzzelli, Angelo Luca, Bruno Gridelli

Published in: Pediatric Radiology | Issue 7/2008

Abstract

Langerhans cell histiocytosis (LCH) is a disorder of unknown pathogenesis affecting one or more organs (unifocal or disseminated form) due to clonal proliferation of Langerhans cells. Liver involvement is more frequent in the disseminated form and the radiological findings of end-stage liver disease due to LCH are similar to those of sclerosing cholangitis. We present the multidetector CT findings in two children with LCH liver involvement and the unique finding of calcification of the biliary wall.

Alston RD, Tatevossian RG, McNally RJ et al (2007) Incidence and survival of childhood Langerhans cell histiocytosis in Northwest England from 1954 to 1998. Pediatr Blood Cancer 48:555–560PubMedCrossRef

Broadbent V, Egeler RM, Nesbit ME Jr (1994) Langerhans’ cell histiocytosis – clinical and epidemiological aspects. Br J Cancer 70 [Suppl XXIII]:S11

Braier J, Ciocca M, Latella A et al (2002) Cholestasis, sclerosing cholangitis and liver transplantation in Langerhans cell histiocytosis. Med Pediatr Oncol 38:178–182PubMedCrossRef

Wong A, Ortiz-Neira CL, Reslan WA et al (2006) Liver involvement in Langerhans cell histiocytosis. Pediatr Radiol 36:1105–1107PubMedCrossRef

Jaffe R (2004) Liver involvement in the histiocytic disorders of childhood. Pediatr Dev Pathol 7:214–225PubMed

Nezelof C, Basset F (2004) An hypothesis Langerhans cell histiocytosis: the failure of the immune system to switch from an innate to an adaptive mode. Pediatr Blood Cancer 42:398–400PubMedCrossRef

Kilborn TN, Teh J, Goodman TR (2003) Paediatric manifestations of Langerhans cell histiocytosis: a review of the clinical and radiological findings. Clin Radiol 58:269–278PubMedCrossRef

Pagnoux C, Hayem G, Roux F et al (2003) Sclerosing cholangitis as a complication of Langerhans’ cell histiocytosis. Rev Med Interne 24:324–327PubMedCrossRef

Kim M, Lyu C, Jin Y et al (1999) Langerhans’ cell histiocytosis as a cause of periportal abnormal signal intensity on MRI. Abdom Imaging 24:373–377PubMedCrossRef

10.

Chaudhary A, Debnath J, Thulkar S et al (2006) Imaging findings in hepatic Langerhans’ cell histiocytosis. Indian J Pediatr 73:1036–1038PubMedCrossRef

11.

Buza N, Lagarde DC, Dash S et al (2004) Langerhans cell histiocytosis: report of a single organ involvement in a child. J Cell Mol Med 8:397–401PubMedCrossRef

12.

Heller GD, Haller JO, Berdon WE et al (1999) Punctate thymic calcification in infants with untreated Langerhans’ cell histiocytosis: report of four new cases. Pediatr Radiol 29:813–815PubMedCrossRef

13.

Arakawa A, Tetsuya M, Yamashita Y et al (1994) Periportal fibrosis in Langerhans’ cell histiocytosis mimicking multiple liver tumors: US, CT and MR findings. J Comput Assist Tomogr 18:157–159PubMedCrossRef

Title: Biliary wall calcification in Langerhans cell histiocytosis: report of two cases
Authors: Settimo Caruso
Roberto Miraglia
Luigi Maruzzelli
Angelo Luca
Bruno Gridelli
Publication date: 01-07-2008
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 7/2008
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-008-0809-x

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Biliary wall calcification in Langerhans cell histiocytosis: report of two cases

Abstract

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