Published in:
01-02-2005 | Original Article
In vivo MRI measurement of blood oxygen saturation in children with congenital heart disease
Authors:
Lynne E. Nield, Xiu-Ling L. Qi, Emanuela R. Valsangiacomo, Christopher K. Macgowan, Graham A. Wright, Lisa K. Hornberger, Shi-Joon Yoo
Published in:
Pediatric Radiology
|
Issue 2/2005
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Abstract
Objective: The purpose of this prospective study was to measure in vivo blood oxygen saturation (%O2) by MRI in children with congenital heart disease (CHD) using population-based values for T2O (T2 signal decay of fully oxygenated blood) and K (a parameter representing the deoxyhemoglobin effect) and compare the %O2 with direct cardiac catheterization measurements. Background: MRI can determine %O2 using in vivo measurement of signal decay (T2) and an in vitro calibration curve relating T2 and %O2, based on the equation: 1/T2=1/T2O+K(1−%O2/100)2. Recent studies have correlated the T2/%O2 in children with CHD with the adult calibration statistics. Methods: A total of ten children (five male, five female) with single ventricle CHD (median age 4.8 months, range 2 months to 4.4 years) undergoing cardiac catheterization were included in the study. The blood T2 measurements for each patient were performed in a 1.5 T GE CV scanner. The %O2 was then calculated based on the equation using values of T2O determined from individual hematocrits, and a population average value of K derived for children. The %O2 values were compared with direct %O2 measurements from cardiac catheterization. Results: The %O2 values by MRI were strongly correlated with direct cardiac catheterization measurements (R=0.825; P<0.001). Conclusion: The study indicates that the noninvasive measurement of %O2 by MRI can accurately measure oxygen saturation in children with complex CHD.