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22-11-2022 | Aneurysm | Research

Longitudinal Cardiac Outcomes of Multisystem Inflammatory Syndrome in Children: A Systematic Review and Meta-Analysis

Authors: Jun Yasuhara, Kaihei Masuda, Kae Watanabe, Takuro Shirasu, Hisato Takagi, Naokata Sumitomo, Simon Lee, Toshiki Kuno

Published in: Pediatric Cardiology | Issue 4/2023

Abstract

There is a paucity of longitudinal data on cardiac outcomes in multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19. We aimed to investigate the longitudinal cardiovascular outcomes in MIS-C. PubMed and EMBASE were searched through May 2022. Observational studies were included, reporting mid-term (≥ 3 months) outcomes in children (aged < 21) with MIS-C. Data were extracted by two researchers. Longitudinal outcomes were synthesized by a one-group meta-analysis using a random-effects model. Eleven studies with a follow-up period (3 months to 1 year) were identified, including 547 MIS-C patients. The mortality was 2.5% (95% CI 1.3–4.9). The majority of left ventricular (LV) systolic dysfunction present in 46.8% (95% CI 32.7–61.3) in the acute phase resolved by 3 months, and the prevalence of LV systolic dysfunction was 1.7% (95% CI 0.5–5.7) and 2.1% (95% CI 0.8–5.4) at 3 month and 6 month follow-up, respectively. Additionally, the persistent LV systolic dysfunction in the small population was mild. However, coronary abnormalities such as coronary artery dilatation or aneurysms, seen in 23.7% (95% CI 17.7–31.1) at baseline, persisted in 4.7% (95% CI 1.5–14.3) at 3 months and 5.2% (95% CI 3.0–8.9) at 6 months. Mitral regurgitation (MR), which was observed in 56.6% (95% CI 27.7–81.6) at baseline, also persisted in 7.5% at 6 months. In conclusion, our study demonstrated largely favorable cardiac outcomes, suggesting resolution of LV systolic dysfunction in the majority of cases. However, coronary abnormalities and MR persisted in a subset of patients at mid-term follow-up.

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Title: Longitudinal Cardiac Outcomes of Multisystem Inflammatory Syndrome in Children: A Systematic Review and Meta-Analysis
Authors: Jun Yasuhara
Kaihei Masuda
Kae Watanabe
Takuro Shirasu
Hisato Takagi
Naokata Sumitomo
Simon Lee
Toshiki Kuno
Publication date: 22-11-2022
Publisher: Springer US
Keywords: Aneurysm
Aneurysm
COVID-19
Published in: Pediatric Cardiology / Issue 4/2023
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-022-03052-2

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Longitudinal Cardiac Outcomes of Multisystem Inflammatory Syndrome in Children: A Systematic Review and Meta-Analysis

Abstract

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Abstract

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