Trisomy 13 in a 9-Year-Old Girl with Left Ventricular Noncompaction

Excerpt

Trisomy 13 is one of the most common chromosomal disorders, resulting in multiple congenital anomalies such as heart defects, cystic hygroma, facial deformities, and genital anomalies. Population-based studies [1] have shown that the median survival time for patients with trisomy 13 ranges from 3 to 14 days and that less than 10% of patients survive for 1 year. Jones et al. [2] reported that the 1-year survival rate for trisomy 13 is 5.6–8.6%. Congenital heart anomalies occur in 80–100% of patients with trisomy 13 and include atrial septal defect, ventricular septal defect, and patent ductus arteriosus. However, only one case of left ventricular noncompaction (LVNC) has been reported [3]. …