Skip to main content
Top
Published in: Urolithiasis 5/2004

01-10-2004 | Original Paper

The impact of dietary oxalate on kidney stone formation

Authors: Ross P. Holmes, Dean G. Assimos

Published in: Urolithiasis | Issue 5/2004

Login to get access

Abstract

The role of dietary oxalate in calcium oxalate kidney stone formation remains unclear. However, due to the risk for stone disease that is associated with a low calcium intake, dietary oxalate is believed to be an important contributing factor. In this review, we have examined the available evidence related to the ingestion of dietary oxalate, its intestinal absorption, and its handling by the kidney. The only difference identified to date between normal individuals and those who form stones is in the intestinal absorption of oxalate. Differences in dietary oxalate intake and in renal oxalate excretion are two other parameters that are likely to receive close scrutiny in the near future, because the research tools required for these investigations are now available. Such research, together with more extensive examinations of intestinal oxalate absorption, should help clarify the role of dietary oxalate in stone formation.
Literature
1.
go back to reference Zarembski PM, Hodgkinson A (1969) Some factors influencing the urinary excretion of oxalic acid in man. Clinica Chimica Acta 25: 1CrossRef Zarembski PM, Hodgkinson A (1969) Some factors influencing the urinary excretion of oxalic acid in man. Clinica Chimica Acta 25: 1CrossRef
2.
go back to reference Holmes RP, Goodman HO, Assimos DG (2001) Contribution of dietary oxalate to urinary oxalate excretion. Kidney Int 59: 270CrossRefPubMed Holmes RP, Goodman HO, Assimos DG (2001) Contribution of dietary oxalate to urinary oxalate excretion. Kidney Int 59: 270CrossRefPubMed
3.
go back to reference Holmes RP, Kennedy M (2000) Estimation of the oxalate content of foods and daily oxalate intake. Kidney Int 57: 1662CrossRefPubMed Holmes RP, Kennedy M (2000) Estimation of the oxalate content of foods and daily oxalate intake. Kidney Int 57: 1662CrossRefPubMed
4.
go back to reference Siener R, Ebert D, Nicolav C, Hesse A (2003) Dietary risk factors for hyperoxaluria in calcium oxalate stone formers. Kidney Int 63: 1037CrossRefPubMed Siener R, Ebert D, Nicolav C, Hesse A (2003) Dietary risk factors for hyperoxaluria in calcium oxalate stone formers. Kidney Int 63: 1037CrossRefPubMed
5.
go back to reference Honow R, Hesse A (2002) Comparison of extraction methods for the determination of soluble and total oxalate in foods by HPLC-enzyme-reactor. Food Chem 78: 511CrossRef Honow R, Hesse A (2002) Comparison of extraction methods for the determination of soluble and total oxalate in foods by HPLC-enzyme-reactor. Food Chem 78: 511CrossRef
6.
go back to reference Curhan GC, Willett WC, Rimm EB, Stampfer MJ (1993) A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med 328: 833 Curhan GC, Willett WC, Rimm EB, Stampfer MJ (1993) A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med 328: 833
7.
go back to reference Holmes RP, Goodman HO, Assimos DG (1995) Dietary oxalate and its intestinal absorption. Scanning Microsc 9: 1109PubMed Holmes RP, Goodman HO, Assimos DG (1995) Dietary oxalate and its intestinal absorption. Scanning Microsc 9: 1109PubMed
8.
go back to reference Hesse A, Schneeberger W, Engfeld S, Unruh GEV, Sauerbruch T (1999) Intestinal hyperabsorption of oxalate in calcium oxalate stone formers: application of a new test with [13C2]oxalate. J Am Soc Nephrol 10 [Suppl 14]: S329 Hesse A, Schneeberger W, Engfeld S, Unruh GEV, Sauerbruch T (1999) Intestinal hyperabsorption of oxalate in calcium oxalate stone formers: application of a new test with [13C2]oxalate. J Am Soc Nephrol 10 [Suppl 14]: S329
9.
go back to reference Hatch M, Freel RW, Vaziri ND (1999) Regulatory aspects of oxalate secretion in enteric oxalate elimination. J Am Soc Nephrol 10 [Suppl 14]: S324 Hatch M, Freel RW, Vaziri ND (1999) Regulatory aspects of oxalate secretion in enteric oxalate elimination. J Am Soc Nephrol 10 [Suppl 14]: S324
10.
go back to reference Krishnamurthy M, Hruska KA, Chandhoke PS (2003) The urinary response to an oral oxalate load in recurrent calcium stone formers. J Urol 169: 2030PubMed Krishnamurthy M, Hruska KA, Chandhoke PS (2003) The urinary response to an oral oxalate load in recurrent calcium stone formers. J Urol 169: 2030PubMed
11.
go back to reference Prenen JAC, Boer P, Mees EJD (1984) Absorption kinetics of oxalate from oxalate-rich food in man. Am J Clin Nutr 40: 1007PubMed Prenen JAC, Boer P, Mees EJD (1984) Absorption kinetics of oxalate from oxalate-rich food in man. Am J Clin Nutr 40: 1007PubMed
12.
go back to reference Hess B, Jost C, Zipperle L, Takkinen R, Jaeger P (1998) High-calcium intake abolishes hyperoxaluria and reduces urinary crystallization during a 20-fold normal oxalate load in humans. Nephrol Dial Transplant 13: 2241CrossRefPubMed Hess B, Jost C, Zipperle L, Takkinen R, Jaeger P (1998) High-calcium intake abolishes hyperoxaluria and reduces urinary crystallization during a 20-fold normal oxalate load in humans. Nephrol Dial Transplant 13: 2241CrossRefPubMed
13.
go back to reference Liebman M, Chai W (1997) Effect of dietary calcium on urinary oxalate excretion after oxalate loads. Am J Clin Nutr 65: 1453PubMed Liebman M, Chai W (1997) Effect of dietary calcium on urinary oxalate excretion after oxalate loads. Am J Clin Nutr 65: 1453PubMed
14.
go back to reference Sidhu H, Schmidt ME, CorneliusT JG, Thamiselvam S, Khan SR, Hesse A, Peck AB (1999) Direct correlation between hyperoxaluria/oxalate stone disease and the absence of the gastrointestinal tract dwelling bacterium Oxalobacter formigenes: possible prevention by gut recolonization or enzyme replacement therapy. J Am Soc Nephrol 10: S334PubMed Sidhu H, Schmidt ME, CorneliusT JG, Thamiselvam S, Khan SR, Hesse A, Peck AB (1999) Direct correlation between hyperoxaluria/oxalate stone disease and the absence of the gastrointestinal tract dwelling bacterium Oxalobacter formigenes: possible prevention by gut recolonization or enzyme replacement therapy. J Am Soc Nephrol 10: S334PubMed
15.
go back to reference Mikami K, Akakura K, Takei K, Ueda T, Mizoguchi K, Noda M, Miyake M, Ito H (2003) Association of absence of intestinal oxalate degrading bacteria with urinary calcium oxalate stone formation. Int J Urol 10: 293CrossRefPubMed Mikami K, Akakura K, Takei K, Ueda T, Mizoguchi K, Noda M, Miyake M, Ito H (2003) Association of absence of intestinal oxalate degrading bacteria with urinary calcium oxalate stone formation. Int J Urol 10: 293CrossRefPubMed
16.
go back to reference Troxel SA, Sidhu H, Kaul P, Low RK (2003) Intestinal Oxalobacter formigenes colonization in calcium oxalate stone formers and its relation to urinary oxalate. J Endourol 17: 173CrossRefPubMed Troxel SA, Sidhu H, Kaul P, Low RK (2003) Intestinal Oxalobacter formigenes colonization in calcium oxalate stone formers and its relation to urinary oxalate. J Endourol 17: 173CrossRefPubMed
17.
go back to reference Unruh GE von, Voss S, Sauerbruch T, Hesse A (2003) Reference range for gastrointestinal oxalate absorption measured with a standardized [13C2] oxalate absorption test. J Urol 169: 687PubMed Unruh GE von, Voss S, Sauerbruch T, Hesse A (2003) Reference range for gastrointestinal oxalate absorption measured with a standardized [13C2] oxalate absorption test. J Urol 169: 687PubMed
18.
go back to reference Holmes RP, Assimos DG, Goodman HO (1998) Genetic and dietary influences on urinary oxalate excretion. Urol Res 26: 195CrossRefPubMed Holmes RP, Assimos DG, Goodman HO (1998) Genetic and dietary influences on urinary oxalate excretion. Urol Res 26: 195CrossRefPubMed
19.
go back to reference Mount DB, Romero MF (2004) The SLC26 gene family of multifunctional anion exchangers. Pflugers Arch-Eur J Physiol 447: 710 Mount DB, Romero MF (2004) The SLC26 gene family of multifunctional anion exchangers. Pflugers Arch-Eur J Physiol 447: 710
20.
go back to reference Hodgkinson A, Wilkinson R (1974) Plasma oxalate concentration and renal excretion of oxalate in man. Clin Sci Mol Med 46: 61PubMed Hodgkinson A, Wilkinson R (1974) Plasma oxalate concentration and renal excretion of oxalate in man. Clin Sci Mol Med 46: 61PubMed
21.
go back to reference Prenen JAC, Boer P, Mees EJD, Endeman HJ, Spoor SM, Oei HY (1982) Renal clearance of [14C]oxalate:comparison of constant-infusion with single-injection techniques. Clin Sci 63: 47PubMed Prenen JAC, Boer P, Mees EJD, Endeman HJ, Spoor SM, Oei HY (1982) Renal clearance of [14C]oxalate:comparison of constant-infusion with single-injection techniques. Clin Sci 63: 47PubMed
22.
go back to reference Greger R, Lang F, Oberleithner H, Deetjen P (1978) Handling of oxalate by the rat kidney. Pflugers Arch 374: 243PubMed Greger R, Lang F, Oberleithner H, Deetjen P (1978) Handling of oxalate by the rat kidney. Pflugers Arch 374: 243PubMed
23.
go back to reference Schwille PO, Manoharan M, Rumenapf G, Wolfel G, Berens H (1989) Oxalate measurement in the picomol range by ion chromatography: values in fasting plasma and urine of controls and patients with idiopathic calcium urolithiasis. J Clin Chem Clin Biochem 27: 87PubMed Schwille PO, Manoharan M, Rumenapf G, Wolfel G, Berens H (1989) Oxalate measurement in the picomol range by ion chromatography: values in fasting plasma and urine of controls and patients with idiopathic calcium urolithiasis. J Clin Chem Clin Biochem 27: 87PubMed
24.
go back to reference Cattell WR, Spencer AG, Taylor GW, Watts RWE (1962) The mechanism of the renal excretion of oxalate in the dog. Clin Sci 22: 43PubMed Cattell WR, Spencer AG, Taylor GW, Watts RWE (1962) The mechanism of the renal excretion of oxalate in the dog. Clin Sci 22: 43PubMed
25.
go back to reference Williams HE, Johnson GA, Smith LH (1971) The renal clearance of oxalate in normal subjects and patients with primary hyperoxaluria. Clin Sci 41: 213PubMed Williams HE, Johnson GA, Smith LH (1971) The renal clearance of oxalate in normal subjects and patients with primary hyperoxaluria. Clin Sci 41: 213PubMed
26.
go back to reference Weinman EJ, Frankfurt SJ, Ince A, Sansom S (1978) Renal tubular transport of organic acids. Studies with oxalate and para-aminohippurate in the rat. J Clin Invest 61: 801PubMed Weinman EJ, Frankfurt SJ, Ince A, Sansom S (1978) Renal tubular transport of organic acids. Studies with oxalate and para-aminohippurate in the rat. J Clin Invest 61: 801PubMed
27.
go back to reference Tremaine LM, Bird JE, Quebbemann AJ (1985) Renal tubular excretory transport of oxalate. J Pharmacol Exp Therap 233: 7 Tremaine LM, Bird JE, Quebbemann AJ (1985) Renal tubular excretory transport of oxalate. J Pharmacol Exp Therap 233: 7
28.
go back to reference Knight TF, Sansom SC, Senekjian HO, Weinman EJ (1981) Oxalate secretion in the rat proximal tubule. AmeJ Physiol 240: F295 Knight TF, Sansom SC, Senekjian HO, Weinman EJ (1981) Oxalate secretion in the rat proximal tubule. AmeJ Physiol 240: F295
29.
go back to reference Markovich D, Bissig M, Sorribas V, Hagenbuch B, Meier PJ, Murer H (1994) Expression of rat renal sulfate transport systems in Xenopus laevis oocytes. J Biol Chem 269: 3022PubMed Markovich D, Bissig M, Sorribas V, Hagenbuch B, Meier PJ, Murer H (1994) Expression of rat renal sulfate transport systems in Xenopus laevis oocytes. J Biol Chem 269: 3022PubMed
30.
go back to reference Karniski LP, Lotscher M, Fucentese M, Hilfiker H, Biber J, Murer H (1998) Immunolocalization of sat-1 sulfate/oxalate/bicarbonate anion exchanger in the rat kidney. Am J Physiol 275: F79 Karniski LP, Lotscher M, Fucentese M, Hilfiker H, Biber J, Murer H (1998) Immunolocalization of sat-1 sulfate/oxalate/bicarbonate anion exchanger in the rat kidney. Am J Physiol 275: F79
31.
go back to reference Jiang Z, Grichtchenko II, Boron WF, Aronson PS (2002) Specificity of anion exchange mediated by mouse slc26a6. J Biol Chem 277: 33963CrossRefPubMed Jiang Z, Grichtchenko II, Boron WF, Aronson PS (2002) Specificity of anion exchange mediated by mouse slc26a6. J Biol Chem 277: 33963CrossRefPubMed
32.
go back to reference Xie Q, Welch R, Mercado A, Romero MF, Mount DM (2002) Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. Am J Physiol 283: F826 Xie Q, Welch R, Mercado A, Romero MF, Mount DM (2002) Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. Am J Physiol 283: F826
33.
go back to reference Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (2002) Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. J Biol Chem 277: 14246CrossRefPubMed Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (2002) Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. J Biol Chem 277: 14246CrossRefPubMed
34.
go back to reference Knauf F, Yang C-L, Thomson RB, Mentone AA, Giebisch G, Aronson PS (2001) Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A 98: 9425CrossRefPubMed Knauf F, Yang C-L, Thomson RB, Mentone AA, Giebisch G, Aronson PS (2001) Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A 98: 9425CrossRefPubMed
35.
go back to reference Lohi H, Lamprecht G, Markovich D, Heil A, Kujala M, Seidler U, Kere J (2003) Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains. Am J Physiol 284: C769 Lohi H, Lamprecht G, Markovich D, Heil A, Kujala M, Seidler U, Kere J (2003) Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains. Am J Physiol 284: C769
36.
go back to reference Selvam R (2002) Calcium oxalate stone disease: role of lipid peroxidation and antioxidants. Urol Res 30: 35PubMed Selvam R (2002) Calcium oxalate stone disease: role of lipid peroxidation and antioxidants. Urol Res 30: 35PubMed
37.
go back to reference Jonassen JA, Cao LC, Honeyman T, Scheid CR (2003) Mechanisms mediating oxalate-induced alterations in renal cell functions. Crit Rev Eukaryot Gene Expr 13: 55PubMed Jonassen JA, Cao LC, Honeyman T, Scheid CR (2003) Mechanisms mediating oxalate-induced alterations in renal cell functions. Crit Rev Eukaryot Gene Expr 13: 55PubMed
38.
go back to reference Fan J, Chandhkoe PS (1999) Examination of crystalluria in freshly voided urines of recurrent calcium stone formers and normal individuals using a new filter technique. J Urol 161: 1685PubMed Fan J, Chandhkoe PS (1999) Examination of crystalluria in freshly voided urines of recurrent calcium stone formers and normal individuals using a new filter technique. J Urol 161: 1685PubMed
39.
go back to reference Koul S, Chaturvedi LS, Sekhon A, Bhandari A, Menon M, Koul HK (2002) Effects of oxalate on the re-initiation of DNA synthesis in LLC-PK1 cells do not involve p42/44 MAP kinase activation. Kidney Int 61: 525CrossRefPubMed Koul S, Chaturvedi LS, Sekhon A, Bhandari A, Menon M, Koul HK (2002) Effects of oxalate on the re-initiation of DNA synthesis in LLC-PK1 cells do not involve p42/44 MAP kinase activation. Kidney Int 61: 525CrossRefPubMed
40.
go back to reference Borghi L, Schianchi T, Meschi T, Guerra A, Allegri F, Maggiore U, Novarini A (2002) Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. N Engl J Med 346: 77 Borghi L, Schianchi T, Meschi T, Guerra A, Allegri F, Maggiore U, Novarini A (2002) Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. N Engl J Med 346: 77
41.
go back to reference Albihn PBE, Savage GP (2001) The bioavailability of oxalate from oca (Oxalis tuberosa). J Urol 166: 420CrossRefPubMed Albihn PBE, Savage GP (2001) The bioavailability of oxalate from oca (Oxalis tuberosa). J Urol 166: 420CrossRefPubMed
42.
go back to reference Massey LK, Grentz LM, Horner HT, Palmer RG (2002) Soybean and soyfood consumption increase oxalate excretion. Top Clin Nutr 17: 49 Massey LK, Grentz LM, Horner HT, Palmer RG (2002) Soybean and soyfood consumption increase oxalate excretion. Top Clin Nutr 17: 49
43.
go back to reference Brinkley L, McGuire J, Gregory J, Pak CY (1981) Bioavailability of oxalate in foods. Urology 17: 534PubMed Brinkley L, McGuire J, Gregory J, Pak CY (1981) Bioavailability of oxalate in foods. Urology 17: 534PubMed
44.
go back to reference Brogren M, Savage GP (2003) Bioavailability of soluble oxalate from spinach eaten with and without milk products. Asia Pacific J Clin Nutr 12: 219 Brogren M, Savage GP (2003) Bioavailability of soluble oxalate from spinach eaten with and without milk products. Asia Pacific J Clin Nutr 12: 219
45.
go back to reference Savage GP, Charrier MJS, Vanhanen L (2003) Bioavailability of soluble oxalate from tea and the effect of consuming milk with the tea. Eur J Clin Nutr 57: 415CrossRefPubMed Savage GP, Charrier MJS, Vanhanen L (2003) Bioavailability of soluble oxalate from tea and the effect of consuming milk with the tea. Eur J Clin Nutr 57: 415CrossRefPubMed
46.
go back to reference Barilla DE, Notz C, Kennedy D, Pak CYC (1978) Renal oxalate excretion following oral oxalate loads in patients with ileal disease and with renal and absorptive hypercalciurias. Effect of calcium and magnesium. Am J Med 64: 579CrossRefPubMed Barilla DE, Notz C, Kennedy D, Pak CYC (1978) Renal oxalate excretion following oral oxalate loads in patients with ileal disease and with renal and absorptive hypercalciurias. Effect of calcium and magnesium. Am J Med 64: 579CrossRefPubMed
Metadata
Title
The impact of dietary oxalate on kidney stone formation
Authors
Ross P. Holmes
Dean G. Assimos
Publication date
01-10-2004
Publisher
Springer-Verlag
Published in
Urolithiasis / Issue 5/2004
Print ISSN: 2194-7228
Electronic ISSN: 2194-7236
DOI
https://doi.org/10.1007/s00240-004-0437-3

Other articles of this Issue 5/2004

Urolithiasis 5/2004 Go to the issue