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01-05-2003 | Original Paper

Efficacy of postoperative steroids on ischemic skin flap survival in rats

Authors: Bekir Kuru, Soykan Dinç, Mithat Çamlibel, Engin Durmuş, Haluk Alagöl

Published in: European Journal of Plastic Surgery | Issue 2/2003

Abstract

Necrosis of skin flaps remains a significant clinical problem. This study examined whether steroids improve skin flap survival in rats. Random skin flaps were raised in 30 male Sprague-Dawley rats. Intramuscular methylprednisolone (n=15) or saline solution (n=15) were administered 1, 24, and 48 h after flap elevation. Surviving flap areas were measured after 7 days. The mean surviving flap area in the methylprednisolone group was greater than that in controls (916 vs. 675 mm). These results suggest that postoperative methylprednisolone improves skin flap viability in the ischemic rat flap model.

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Title: Efficacy of postoperative steroids on ischemic skin flap survival in rats
Authors: Bekir Kuru
Soykan Dinç
Mithat Çamlibel
Engin Durmuş
Haluk Alagöl
Publication date: 01-05-2003
Publisher: Springer-Verlag
Published in: European Journal of Plastic Surgery / Issue 2/2003
Print ISSN: 0930-343X
Electronic ISSN: 1435-0130
DOI: https://doi.org/10.1007/s00238-003-0484-y

Keynote webinar | Spotlight on medication adherence

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Efficacy of postoperative steroids on ischemic skin flap survival in rats

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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