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Published in: Neuroradiology 6/2019

01-06-2019 | Obesity | Functional Neuroradiology

Gray matter reduction related to decreased serum creatinine and increased triglyceride, Hemoglobin A1C, and low-density lipoprotein in subjects with obesity

Authors: Han Shan, Panlong Li, Hua Liu, Binbin Nie, Xiaolong Yin, Tianhao Zhang, Xi Sun, Wei Zhang, Ting Feng, Luying Wang, Yichao Hu, Guanglong Dong, Hongkai Gao, Jin Du, Lin Ma, Demin Li, Baoci Shan

Published in: Neuroradiology | Issue 6/2019

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Abstract

Purpose

Altered brain volume and metabolic variables have been found in subjects with obesity. However, the role of metabolic parameters in gray matter volume (GMV) has been poorly investigated. This study aimed to investigate the relationship between the metabolic parameters and brain volume in subjects with obesity.

Methods

Thirty-seven subjects with obesity and 39 age and sex matched normal-weight controls were included in this study. Eighteen of the 37 participants who underwent sleeve gastrectomy were included in the longitudinal analysis. Blood samples and high-resolution 3T T1-weighted magnetic resonance images were collected. Metabolic parameters in plasma and GMV were measured.

Results

Multiple linear regression analysis showed that gray matter reduction in several cognition-related cortices including right angular gyrus, superior occipital cortex, superior parietal cortex, and cerebellum was related to decreased creatinine, as well as increased triglyceride, HbA1c, and low-density lipoprotein in plasma in subjects with obesity. Weight loss after the surgery induced significant recovery of altered metabolic parameters and decreased gray matter volume. Furthermore, changes in the four metabolic parameters before and after the surgery were associated with changes in gray matter volume.

Conclusion

Our results suggest that the gray matter reduction is related to decreased creatinine as well as increased triglyceride, HbA1c, and low-density lipoprotein in plasma in subjects with obesity.
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Metadata
Title
Gray matter reduction related to decreased serum creatinine and increased triglyceride, Hemoglobin A1C, and low-density lipoprotein in subjects with obesity
Authors
Han Shan
Panlong Li
Hua Liu
Binbin Nie
Xiaolong Yin
Tianhao Zhang
Xi Sun
Wei Zhang
Ting Feng
Luying Wang
Yichao Hu
Guanglong Dong
Hongkai Gao
Jin Du
Lin Ma
Demin Li
Baoci Shan
Publication date
01-06-2019
Publisher
Springer Berlin Heidelberg
Keywords
Obesity
Obesity
Published in
Neuroradiology / Issue 6/2019
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-019-02202-3

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