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Neuroradiology

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01-12-2016 | Functional Neuroradiology

Micro-structural white matter abnormalities in type 2 diabetic patients: a DTI study using TBSS analysis

Authors: Xin Tan, Peng Fang, Jie An, Huan Lin, Yi Liang, Wen Shen, Xi Leng, Chi Zhang, Yanting Zheng, Shijun Qiu

Published in: Neuroradiology | Issue 12/2016

Abstract

Introduction

Patients with type 2 diabetes mellitus (T2DM) have usually been found cognitive impairment associated with brain white matter (WM) abnormalities. However, findings have varied across studies, and any potential relationship with Alzheimer’s disease (AD) remains unclear. The aim of this study was to assess the whole-brain WM integrity of T2DM patients and to compare our findings with those of published AD cases.

Methods

In this study, we used diffusion tensor imaging (DTI) combined with tract-based spatial statistics (TBSS) to investigate whole-brain WM abnormalities in 48 T2DM patients and 48 healthy controls. The effects of age and gender were also evaluated.

Results

In our study, significantly decreasing FA and increasing MD and DA values (P<0.05) were found in some WM regions closely related to the default mode network (DMN), including cingulum, the right frontal lobe involving the right uncinate fasciculus (UF), bilateral parietal lobes involving the superior longitudinal fasciculus (SLF) and the inferior longitudinal fasciculus (ILF), and the right middle temporal gyrus (MTG) involving the UF and the ILF. We also found abnormalities in the thalamus involving the fornix (FX), anterior thalamic radiation (ATR), and posterior thalamic radiation (PTR). The damaged regions above are similar to those found in patients with AD, as reported in previous studies.

Conclusion

The present study not only provides useful information about the WM regions and tracts affected by T2DM but also offers insight into the underlying neuropathological process in T2DM patients and the relationship between T2DM and AD.

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Title: Micro-structural white matter abnormalities in type 2 diabetic patients: a DTI study using TBSS analysis
Authors: Xin Tan
Peng Fang
Jie An
Huan Lin
Yi Liang
Wen Shen
Xi Leng
Chi Zhang
Yanting Zheng
Shijun Qiu
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 12/2016
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-016-1752-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Micro-structural white matter abnormalities in type 2 diabetic patients: a DTI study using TBSS analysis

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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