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01-08-2015 | Diagnostic Neuroradiology

Early CT perfusion changes and blood–brain barrier permeability after aneurysmal subarachnoid hemorrhage

Authors: Amanda Murphy, Airton Leonardo de Oliveira Manoel, Kyle Burgers, Ekaterina Kouzmina, Ting Lee, R. Loch Macdonald, Aditya Bharatha

Published in: Neuroradiology | Issue 8/2015

Abstract

Introduction

Early brain injury (EBI) can occur within 72 h of aneurysmal subarachnoid hemorrhage (aSAH). The objective of this study was to determine if there are differences in early CTP parameters (<72 h) with respect to delayed cerebral ischemia (DCI), cerebral infarction, and functional outcome.

Methods

We performed a prospective cohort study of aSAH patients admitted to a single tertiary care center. MTT, CBF and blood–brain barrier permeability (PS) were quantified with CTP within 72 h of aneurysm rupture. Primary outcomes were functional outcome by the Modified Rankin Scale (mRS) at 3 months and cerebral infarction. Secondary outcome was the development of DCI. Differences between early CTP parameters were determined with respect to primary and secondary outcomes.

Results

Fifty aSAH patients were included in the final analysis. MTT was significantly higher in patients who developed DCI (6.7 ± 1.2 vs 5.9 ± 1.0; p = 0.03) and cerebral infarction (7.0 ± 1.2 vs 5.9 ± 0.9; p = 0.007); however, no difference in MTT was found between patients with and without a poor outcome (mRS > 2). Early CBF and PS did not differ with respect to functional outcome, DCI, and cerebral infarction.

Conclusions

Elevated MTT within 72 h of aneurysm rupture is associated with DCI and cerebral infarction but not with long-term functional outcome. Blood–brain barrier permeability, as assessed by CT perfusion, was not associated with DCI or worse outcome in this cohort.

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Title: Early CT perfusion changes and blood–brain barrier permeability after aneurysmal subarachnoid hemorrhage
Authors: Amanda Murphy
Airton Leonardo de Oliveira Manoel
Kyle Burgers
Ekaterina Kouzmina
Ting Lee
R. Loch Macdonald
Aditya Bharatha
Publication date: 01-08-2015
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 8/2015
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-015-1529-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Early CT perfusion changes and blood–brain barrier permeability after aneurysmal subarachnoid hemorrhage

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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