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01-12-2014 | Diagnostic Neuroradiology

Discrimination between glioma grades II and III in suspected low-grade gliomas using dynamic contrast-enhanced and dynamic susceptibility contrast perfusion MR imaging: a histogram analysis approach

Authors: Anna Falk, Markus Fahlström, Egill Rostrup, Shala Berntsson, Maria Zetterling, Arvid Morell, Henrik B.W. Larsson, Anja Smits, Elna-Marie Larsson

Published in: Neuroradiology | Issue 12/2014

Abstract

Introduction

Perfusion magnetic resonance imaging (MRI) can be used in the pre-operative assessment of brain tumours. The aim of this prospective study was to identify the perfusion parameters from dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) perfusion imaging that could best discriminate between grade II and III gliomas.

Methods

MRI (3 T) including morphological ((T2 fluid attenuated inversion recovery (FLAIR) and T1-weighted (T1W)+Gd)) and perfusion (DCE and DSC) sequences was performed in 39 patients with newly diagnosed suspected low-grade glioma after written informed consent in this review board-approved study. Regions of interests (ROIs) in tumour area were delineated on FLAIR images co-registered to DCE and DSC, respectively, in 25 patients with histopathological grade II (n = 18) and III (n = 7) gliomas. Statistical analysis of differences between grade II and grade III gliomas in histogram perfusion parameters was performed, and the areas under the curves (AUC) from the ROC analyses were evaluated.

Results

In DCE, the skewness of transfer constant (k _trans) was found superior for differentiating grade II from grade III in all gliomas (AUC 0.76). In DSC, the standard deviation of relative cerebral blood flow (rCBF) was found superior for differentiating grade II from grade III gliomas (AUC 0.80).

Conclusions

Histogram parameters from k _trans (DCE) and rCBF (DSC) could most efficiently discriminate between grade II and grade III gliomas.

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Title: Discrimination between glioma grades II and III in suspected low-grade gliomas using dynamic contrast-enhanced and dynamic susceptibility contrast perfusion MR imaging: a histogram analysis approach
Authors: Anna Falk
Markus Fahlström
Egill Rostrup
Shala Berntsson
Maria Zetterling
Arvid Morell
Henrik B.W. Larsson
Anja Smits
Elna-Marie Larsson
Publication date: 01-12-2014
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 12/2014
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-014-1426-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Discrimination between glioma grades II and III in suspected low-grade gliomas using dynamic contrast-enhanced and dynamic susceptibility contrast perfusion MR imaging: a histogram analysis approach

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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